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Science 24 January 1997:
Vol. 275. no. 5299, pp. 533 - 536
DOI: 10.1126/science.275.5299.533
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Reports

Vascular System Defects and Impaired Cell Chemokinesis as a Result of Galpha 13 Deficiency

Stefan Offermanns, Valeria Mancino, Jean-Paul Revel, Melvin I. Simon

Heterotrimeric GTP-binding proteins (G proteins) participate in cellular signaling and regulate a variety of physiological processes. Disruption of the gene encoding the G protein subunit alpha 13 (Galpha 13) in mice impaired the ability of endothelial cells to develop into an organized vascular system, resulting in intrauterine death. In addition, Galpha 13 (-/-) embryonic fibroblasts showed greatly impaired migratory responses to thrombin. These results demonstrate that Galpha 13 participates in the regulation of cell movement in response to specific ligands, as well as in developmental angiogenesis.

Division of Biology 147-75, California Institute of Technology, Pasadena, CA 91125, USA.

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c-Jun Amino-terminal Kinase Is Regulated by Galpha 12/Galpha 13 and Obligate for Differentiation of P19 Embryonal Carcinoma Cells by Retinoic Acid.
E.-H. Jho, R. J. Davis, and C. C. Malbon (1997)
J. Biol. Chem. 272, 24468-24474
   Abstract »    Full Text »    PDF »
Conformational Activation of Radixin by G13 Protein alpha Subunit.
R. Vaiskunaite, V. Adarichev, H. Furthmayr, T. Kozasa, A. Gudkov, and T. A. Voyno-Yasenetskaya (2000)
J. Biol. Chem. 275, 26206-26212
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Mechanisms for Reversible Regulation between G13 and Rho Exchange Factors.
C. D. Wells, M.-Y. Liu, M. Jackson, S. Gutowski, P. M. Sternweis, J. D. Rothstein, T. Kozasa, and P. C. Sternweis (2002)
J. Biol. Chem. 277, 1174-1181
   Abstract »    Full Text »    PDF »
Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.
T. E. Meigs, T. A. Fields, D. D. McKee, and P. J. Casey (2001)
PNAS 98, 519-524
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