Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 January 1997:
Vol. 275. no. 5298, pp. 402 - 404
DOI: 10.1126/science.275.5298.402
Prev | Table of Contents | Next

Reports

Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein

Corinne I. Lasmézas, * Jean-Philippe Deslys, Olivier Robain, Alexandre Jaegly, Vincent Beringue, Jean-Michel Peyrin, Jean-Guy Fournier, Jean-Jacques Hauw, Jean Rossier, Dominique Dormont

The agent responsible for transmissible spongiform encephalopathies (TSEs) is thought to be a malfolded, protease-resistant version (PrPres) of the normal cellular prion protein (PrP). The interspecies transmission of bovine spongiform encephalopathy (BSE) to mice was studied. Although all of the mice injected with homogenate from BSE-infected cattle brain exhibited neurological symptoms and neuronal death, more than 55 percent had no detectable PrPres. During serial passage, PrPres appeared after the agent became adapted to the new host. Thus, PrPres may be involved in species adaptation, but a further unidentified agent may actually transmit BSE.

C. I. Lasmézas, J.-P. Deslys, A. Jaegly, V. Beringue, J.-M. Peyrin, D. Dormont, Commissariat à l'Energie Atomique, Service de Neurovirologie, DSV/DRM/SSA, B.P. 6, 60-68 avenue du General Leclerc, 92265 Fontenay-aux-Roses Cedex, France.
O. Robain, Hôpital Saint Vincent de Paul, INSERM U 29, 74 avenue Denfert-Rochereau, 75674 Paris Cedex 14, France.
J.-G. Fournier, Hôpital de la Salpétrière, INSERM U 153, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
J.-J. Hauw, Hôpital de la Salpétrière, Laboratoire Escourolle, INSERM U 360, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
J. Rossier, Ecole Supérieure de Physique et Chimie Industrielles, CNRS URA 2054, 10 rue Vauquelin, 75231 Paris Cedex 5, France.
*   To whom correspondence should be addressed. E-mail: CORINNE.LASMEZAS{at}cea.fr

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces.
J. A. Edgeworth, G. S. Jackson, A. R. Clarke, C. Weissmann, and J. Collinge (2009)
PNAS 106, 3479-3483
   Abstract »    Full Text »    PDF »
Molecular and Transmission Characteristics of Primary-Passaged Ovine Scrapie Isolates in Conventional and Ovine PrP Transgenic Mice.
A. M. Thackray, L. Hopkins, J. Spiropoulos, and R. Bujdoso (2008)
J. Virol. 82, 11197-11207
   Abstract »    Full Text »    PDF »
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.
A. D. Steele, G. Hutter, W. S. Jackson, F. L. Heppner, A. W. Borkowski, O. D. King, G. J. Raymond, A. Aguzzi, and S. Lindquist (2008)
PNAS 105, 13626-13631
   Abstract »    Full Text »    PDF »
Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy.
C. Zuber, G. Mitteregger, N. Schuhmann, C. Rey, S. Knackmuss, W. Rupprecht, U. Reusch, C. Pace, M. Little, H. A. Kretzschmar, et al. (2008)
J. Gen. Virol. 89, 2055-2061
   Abstract »    Full Text »    PDF »
Induced Neuroprotection Independently From PrPSc Accumulation in a Mouse Model for Prion Disease Treated With Simvastatin.
Y. Haviv, D. Avrahami, H. Ovadia, T. Ben-Hur, R. Gabizon, and R. Sharon (2008)
Arch Neurol 65, 762-775
   Abstract »    Full Text »    PDF »
Semen from scrapie-infected rams does not transmit prion infection to transgenic mice.
P. Sarradin, S. Melo, C. Barc, C. Lecomte, O. Andreoletti, F. Lantier, J.-L. Dacheux, and J.-L. Gatti (2008)
Reproduction 135, 415-418
   Abstract »    Full Text »    PDF »
High Titers of Transmissible Spongiform Encephalopathy Infectivity Associated with Extremely Low Levels of PrPSc in Vivo.
R. M. Barron, S. L. Campbell, D. King, A. Bellon, K. E. Chapman, R. A. Williamson, and J. C. Manson (2007)
J. Biol. Chem. 282, 35878-35886
   Abstract »    Full Text »    PDF »
A General Model of Prion Strains and Their Pathogenicity.
J. Collinge and A. R. Clarke (2007)
Science 318, 930-936
   Abstract »    Full Text »    PDF »
Spiroplasma spp. from transmissible spongiform encephalopathy brains or ticks induce spongiform encephalopathy in ruminants.
F. O. Bastian, D. E. Sanders, W. A. Forbes, S. D. Hagius, J. V. Walker, W. G. Henk, F. M. Enright, and P. H. Elzer (2007)
J. Med. Microbiol. 56, 1235-1242
   Abstract »    Full Text »    PDF »
Modulation of Proteinase K-resistant Prion Protein in Cells and Infectious Brain Homogenate by Redox Iron: Implications for Prion Replication and Disease Pathogenesis.
S. Basu, M. L. Mohan, X. Luo, B. Kundu, Q. Kong, and N. Singh (2007)
Mol. Biol. Cell 18, 3302-3312
   Abstract »    Full Text »    PDF »
Molecular Behaviors of "CH1641-Like" Sheep Scrapie Isolates in Ovine Transgenic Mice (TgOvPrP4).
T. Baron and A.-G. Biacabe (2007)
J. Virol. 81, 7230-7237
   Abstract »    Full Text »    PDF »
Cytosolic Prion Protein Toxicity Is Independent of Cellular Prion Protein Expression and Prion Propagation.
E. M. Norstrom, M. F. Ciaccio, B. Rassbach, R. Wollmann, and J. A. Mastrianni (2007)
J. Virol. 81, 2831-2837
   Abstract »    Full Text »    PDF »
Accumulation of prion protein in the brain that is not associated with transmissible disease.
P. Piccardo, J. C. Manson, D. King, B. Ghetti, and R. M. Barron (2007)
PNAS 104, 4712-4717
   Abstract »    Full Text »    PDF »
Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases.
C. Larramendy-Gozalo, A. Barret, E. Daudigeos, E. Mathieu, L. Antonangeli, C. Riffet, E. Petit, D. Papy-Garcia, D. Barritault, P. Brown, et al. (2007)
J. Gen. Virol. 88, 1062-1067
   Abstract »    Full Text »    PDF »
Mad Fly Disease.
J. Chandran and P. Lewis (2007)
J. Neurosci. 27, 971-972
   Full Text »    PDF »
Prion infectivity in variant Creutzfeldt-Jakob disease rectum.
J D F Wadsworth, S Joiner, K Fox, J M Linehan, M Desbruslais, S Brandner, E A Asante, and J Collinge (2007)
Gut 56, 90-94
   Abstract »    Full Text »    PDF »
PET-blot Analysis Contributes to BSE Strain Recognition in C57Bl/6 Mice.
S. Lezmi, A. Bencsik, and T. Baron (2006)
J. Histochem. Cytochem. 54, 1087-1094
   Abstract »    Full Text »    PDF »
A systematic review of prion therapeutics in experimental models.
C. R Trevitt and J. Collinge (2006)
Brain 129, 2241-2265
   Abstract »    Full Text »    PDF »
Dissociation of pathological and molecular phenotype of variant Creutzfeldt-Jakob disease in transgenic human prion protein 129 heterozygous mice.
E. A. Asante, J. M. Linehan, I. Gowland, S. Joiner, K. Fox, S. Cooper, O. Osiguwa, M. Gorry, J. Welch, R. Houghton, et al. (2006)
PNAS 103, 10759-10764
   Abstract »    Full Text »    PDF »
Probing the Conformation of the Prion Protein within a Single Amyloid Fibril Using a Novel Immunoconformational Assay.
V. Novitskaya, N. Makarava, A. Bellon, O. V. Bocharova, I. B. Bronstein, R. A. Williamson, and I. V. Baskakov (2006)
J. Biol. Chem. 281, 15536-15545
   Abstract »    Full Text »    PDF »
Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep..
O. Andreoletti, N. Morel, C. Lacroux, V. Rouillon, C. Barc, G. Tabouret, P. Sarradin, P. Berthon, P. Bernardet, J. Mathey, et al. (2006)
J. Gen. Virol. 87, 1043-1046
   Abstract »    Full Text »    PDF »
Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis.
M. Kristiansen, M. J. Messenger, P.-C. Klohn, S. Brandner, J. D. F. Wadsworth, J. Collinge, and S. J. Tabrizi (2005)
J. Biol. Chem. 280, 38851-38861
   Abstract »    Full Text »    PDF »
Consensus statement on the bio-safety of urinary-derived gonadotrophins with respect to Creutzfeldt-Jakob disease.
A. H. Balen and I. B. Lumholtz (2005)
Hum. Reprod. 20, 2994-2999
   Abstract »    Full Text »    PDF »
Reciprocal Interference Between Specific CJD and Scrapie Agents in Neural Cell Cultures.
N. Nishida, S. Katamine, and L. Manuelidis (2005)
Science 310, 493-496
   Abstract »    Full Text »    PDF »
Bovine Prion Is Endocytosed by Human Enterocytes via the 37 kDa/67 kDa Laminin Receptor.
E. Morel, T. Andrieu, F. Casagrande, S. Gauczynski, S. Weiss, J. Grassi, M. Rousset, D. Dormont, and J. Chambaz (2005)
Am. J. Pathol. 167, 1033-1042
   Abstract »    Full Text »    PDF »
Molecular neurology of prion disease.
J Collinge (2005)
J. Neurol. Neurosurg. Psychiatry 76, 906-919
   Abstract »    Full Text »    PDF »
Amidation and Structure Relaxation Abolish the Neurotoxicity of the Prion Peptide PrP106-126 in Vivo and in Vitro.
A.-L. Bergstrom, H. Cordes, N. Zsurger, P. M. H. Heegaard, H. Laursen, and J. Chabry (2005)
J. Biol. Chem. 280, 23114-23121
   Abstract »    Full Text »    PDF »
Transmission Barriers for Bovine, Ovine, and Human Prions in Transgenic Mice.
M. R. Scott, D. Peretz, H.-O. B. Nguyen, S. J. DeArmond, and S. B. Prusiner (2005)
J. Virol. 79, 5259-5271
   Abstract »    Full Text »    PDF »
Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock.
J.-Y. Madec, S. Simon, S. Lezmi, A. Bencsik, J. Grassi, and T. Baron (2004)
J. Gen. Virol. 85, 3483-3486
   Abstract »    Full Text »    PDF »
Ionic Strength and Transition Metals Control PrPSc Protease Resistance and Conversion-inducing Activity.
K. Nishina, S. Jenks, and S. Supattapone (2004)
J. Biol. Chem. 279, 40788-40794
   Abstract »    Full Text »    PDF »
Insight into the PrPC -> PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.
F. Eghiaian, J. Grosclaude, S. Lesceu, P. Debey, B. Doublet, E. Treguer, H. Rezaei, and M. Knossow (2004)
PNAS 101, 10254-10259
   Abstract »    Full Text »    PDF »
Subclinical Bovine Spongiform Encephalopathy Infection in Transgenic Mice Expressing Porcine Prion Protein.
J. Castilla, A. Gutierrez-Adan, A. Brun, D. Doyle, B. Pintado, M. A. Ramirez, F. J. Salguero, B. Parra, F. D. S. Segundo, J. M. Sanchez-Vizcaino, et al. (2004)
J. Neurosci. 24, 5063-5069
   Abstract »    Full Text »    PDF »
The p75 Neurotrophin Receptor Can Induce Autophagy and Death of Cerebellar Purkinje Neurons.
M. L. Florez-McClure, D. A. Linseman, C. T. Chu, P. A. Barker, R. J. Bouchard, S. S. Le, T. A. Laessig, and K. A. Heidenreich (2004)
J. Neurosci. 24, 4498-4509
   Abstract »    Full Text »    PDF »
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.
P.-C. Klohn, L. Stoltze, E. Flechsig, M. Enari, and C. Weissmann (2003)
PNAS 100, 11666-11671
   Abstract »    Full Text »    PDF »
A novel generation of heparan sulfate mimetics for the treatment of prion diseases.
K. T. Adjou, S. Simoneau, N. Sales, F. Lamoury, D. Dormont, D. Papy-Garcia, D. Barritault, J.-P. Deslys, and C. I. Lasmezas (2003)
J. Gen. Virol. 84, 2595-2603
   Abstract »    Full Text »    PDF »
Modulation of prion protein structural integrity by geldanamycin.
H.-J. Ochel, G. Gademann, J. Trepel, and L. Neckers (2003)
Glycobiology 13, 655-660
   Abstract »    Full Text »    PDF »
Molecular Distinction between Pathogenic and Infectious Properties of the Prion Protein.
R. Chiesa, P. Piccardo, E. Quaglio, B. Drisaldi, S. L. Si-Hoe, M. Takao, B. Ghetti, and D. A. Harris (2003)
J. Virol. 77, 7611-7622
   Abstract »    Full Text »    PDF »
PrP knock-out and PrP transgenic mice in prion research.
C Weissmann and E Flechsig (2003)
Br. Med. Bull. 66, 43-60
   Abstract »    Full Text »    PDF »
CNS pathogenesis of prion diseases.
S. Brandner (2003)
Br. Med. Bull. 66, 131-139
   Abstract »    Full Text »    PDF »
Subclinical prion infection in humans and animals.
A. F Hill and J. Collinge (2003)
Br. Med. Bull. 66, 161-170
   Abstract »    Full Text »    PDF »
Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease.
L. Manuelidis and Z. Y. Lu (2003)
PNAS 100, 5360-5365
   Abstract »    Full Text »    PDF »
Cell-associated variants of disease-specific prion protein immunolabelling are found in different sources of sheep transmissible spongiform encephalopathy.
M. Jeffrey, S. Martin, and L. Gonzalez (2003)
J. Gen. Virol. 84, 1033-1046
   Abstract »    Full Text »    PDF »
Accumulation of Pathogenic Prion Protein (PrPSc) in Nervous and Lymphoid Tissues of Sheep with Subclinical Scrapie.
C. Ersdal, M. J. Ulvund, S. L. Benestad, and M. A. Tranulis (2003)
Vet. Pathol. 40, 164-174
   Abstract »    Full Text »    PDF »
The immune system and prion diseases: a relationship of complicity and blindness.
P. Aucouturier and C. Carnaud (2002)
J. Leukoc. Biol. 72, 1075-1083
   Abstract »    Full Text »    PDF »
Neurotoxicity and Neurodegeneration When PrP Accumulates in the Cytosol.
J. Ma, R. Wollmann, and S. Lindquist (2002)
Science 298, 1781-1785
   Abstract »    Full Text »    PDF »
Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles.
C. A. Baker, D. Martin, and L. Manuelidis (2002)
J. Virol. 76, 10905-10913
   Abstract »    Full Text »    PDF »
PrPSc accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission.
O. Andreoletti, C. Lacroux, A. Chabert, L. Monnereau, G. Tabouret, F. Lantier, P. Berthon, F. Eychenne, S. Lafond-Benestad, J.-M. Elsen, et al. (2002)
J. Gen. Virol. 83, 2607-2616
   Abstract »    Full Text »    PDF »
Biological and Biochemical Characterization of Sheep Scrapie in Japan.
M. Horiuchi, T. Nemoto, N. Ishiguro, H. Furuoka, S. Mohri, and M. Shinagawa (2002)
J. Clin. Microbiol. 40, 3421-3426
   Abstract »    Full Text »    PDF »
PrP Expression and Replication by Schwann Cells: Implications in Prion Spreading.
J. Follet, C. Lemaire-Vieille, F. Blanquet-Grossard, V. Podevin-Dimster, S. Lehmann, J.-P. Chauvin, J.-P. Decavel, R. Varea, J. Grassi, M. Fontes, et al. (2002)
J. Virol. 76, 2434-2439
   Abstract »    Full Text »    PDF »
Chronic Subclinical Prion Disease Induced by Low-Dose Inoculum.
A. M. Thackray, M. A. Klein, A. Aguzzi, and R. Bujdoso (2002)
J. Virol. 76, 2510-2517
   Abstract »    Full Text »    PDF »
A Critical Review of the Nature of the Spongiform Encephalopathy Agent: Protein Theory Versus Virus Theory.
H. Narang (2002)
Experimental Biology and Medicine 227, 4-19
   Abstract »    Full Text »    PDF »
A Critical Review of Atypical Cerebellum-Type Creutzfeldt-Jakob Disease: Its Relationship to ``New Variant'' CJD and Bovine Spongiform Encephalopathy.
H. K. Narang (2001)
Experimental Biology and Medicine 226, 629-639
   Abstract »    Full Text »    PDF »
Lingering Doubts about Spongiform Encephalopathy and Creutzfeldt-Jakob Disease.
H. K. Narang (2001)
Experimental Biology and Medicine 226, 640-652
   Abstract »    Full Text »    PDF »
Efficient Transmission of Two Different Sheep Scrapie Isolates in Transgenic Mice Expressing the Ovine PrP Gene.
C. Crozet, F. Flamant, A. Bencsik, D. Aubert, J. Samarut, and T. Baron (2001)
J. Virol. 75, 5328-5334
   Abstract »    Full Text »
Prion proteins and the gut: une liaison dangereuse?.
A N SHMAKOV and S GHOSH (2001)
Gut 48, 443-447
   Full Text »    PDF »
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt- Jakob disease: Implications for human health.
C. I. Lasmézas, J.-G. Fournier, V. Nouvel, H. Boe, D. Marcé, F. Lamoury, N. Kopp, J.-J. Hauw, J. Ironside, M. Bruce, et al. (2001)
PNAS
   Abstract »    Full Text »
Molecular Analysis of the Abnormal Prion Protein during Coinfection of Mice by Bovine Spongiform Encephalopathy and a Scrapie Agent.
T. G. M. Baron and A.-G. Biacabe (2001)
J. Virol. 75, 107-114
   Abstract »    Full Text »
Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie.
O. Andréoletti, P. Berthon, D. Marc, P. Sarradin, J. Grosclaude, L. van Keulen, F. Schelcher, J.-M. Elsen, and F. Lantier (2000)
J. Gen. Virol. 81, 3115-3126
   Abstract »    Full Text »
Prion infection impairs the cellular response to oxidative stress.
O. Milhavet, H. E. M. McMahon, W. Rachidi, N. Nishida, S. Katamine, A. Mangé, M. Arlotto, D. Casanova, J. Riondel, A. Favier, et al. (2000)
PNAS
   Abstract »    Full Text »
Species-barrier-independent prion replication in apparently resistant species.
A. F. Hill, S. Joiner, J. Linehan, M. Desbruslais, P. L. Lantos, and J. Collinge (2000)
PNAS 97, 10248-10253
   Abstract »    Full Text »    PDF »
Opposite Effects of Dextran Sulfate 500, the Polyene Antibiotic MS-8209, and Congo Red on Accumulation of the Protease-Resistant Isoform of PrP in the Spleens of Mice Inoculated Intraperitoneally with the Scrapie Agent.
V. Beringue, K. T. Adjou, F. Lamoury, T. Maignien, J.-P. Deslys, R. Race, and D. Dormont (2000)
J. Virol. 74, 5432-5440
   Abstract »    Full Text »
Characterization of the murine BSE infectious agent.
T. Manousis, S. Verghese-Nikolakaki, P. Keyes, M. Sachsamanoglou, M. Dawson, O. Papadopoulos, and T. K. Sklaviadis (2000)
J. Gen. Virol. 81, 1615-1620
   Abstract »    Full Text »
From the Cover: Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans.
M. R. Scott, R. Will, J. Ironside, H.-O. B. Nguyen, P. Tremblay, S. J. DeArmond, and S. B. Prusiner (1999)
PNAS 96, 15137-15142
   Abstract »    Full Text »    PDF »
Detection of Bovine Spongiform Encephalopathy-Specific PrPSc by Treatment with Heat and Guanidine Thiocyanate.
R. K. Meyer, B. Oesch, R. Fatzer, A. Zurbriggen, and M. Vandevelde (1999)
J. Virol. 73, 9386-9392
   Abstract »    Full Text »    PDF »
Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents.
T. Maignien, C. I. Lasmé zas, V. Beringue, D. Dormont, and J.-P. Deslys (1999)
J. Gen. Virol. 80, 3035-3042
   Abstract »    Full Text »
Protease-resistant and Detergent-insoluble Prion Protein Is Not Necessarily Associated with Prion Infectivity.
G. M. Shaked, G. Fridlander, Z. Meiner, A. Taraboulos, and R. Gabizon (1999)
J. Biol. Chem. 274, 17981-17986
   Abstract »    Full Text »    PDF »
Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease.
C. A. Baker, Z. Y. Lu, I. Zaitsev, and L. Manuelidis (1999)
J. Virol. 73, 5089-5097
   Abstract »    Full Text »
MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie.
K. Adjou, R Demaimay, J. Deslys, C. Lasmezas, V Beringue, S Demart, F Lamoury, M Seman, and D Dormont (1999)
J. Gen. Virol. 80, 1079-1085
   Abstract »
Protease-resistant prion protein produced in vitro lacks detectable infectivity.
A. Hill, M Antoniou, and J Collinge (1999)
J. Gen. Virol. 80, 11-14
   Abstract »
Prions.
S. B. Prusiner (1998)
PNAS 95, 13363-13383
   Abstract »    Full Text »    PDF »
The Anti-prion Activity of Congo Red. PUTATIVE MECHANISM.
S. Caspi, M. Halimi, A. Yanai, S. B. Sasson, A. Taraboulos, and R. Gabizon (1998)
J. Biol. Chem. 273, 3484-3489
   Abstract »    Full Text »    PDF »
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice.
M. R. Scott, J. Safar, G. Telling, O. Nguyen, D. Groth, M. Torchia, R. Koehler, P. Tremblay, D. Walther, F. E. Cohen, et al. (1997)
PNAS 94, 14279-14284
   Abstract »    Full Text »    PDF »
Transmissible Spongiform Encephalopathies.
A. M. Haywood (1997)
N. Engl. J. Med. 337, 1821-1828
   Full Text »    PDF »
The prion model for [URE3] of yeast: Spontaneous generation and requirements for propagation.
D. C. Masison, M.-L. Maddelein, and R. B. Wickner (1997)
PNAS 94, 12503-12508
   Abstract »    Full Text »    PDF »
Prion Diseases and the BSE Crisis.
S. B. Prusiner (1997)
Science 278, 245-251
   Abstract »    Full Text »
A new prion controls fungal cell fusion incompatibility.
R. B. Wickner (1997)
PNAS 94, 10012-10014
   Full Text »    PDF »
Evolution of a Strain of CJD That Induces BSE-Like Plaques.
L. Manuelidis, W. Fritch, and Y. Xi (1997)
Science 277, 94-98
   Abstract »    Full Text »
Cleavage of the Amino Terminus of the Prion Protein by Reactive Oxygen Species.
H. E. M. McMahon, A. Mange, N. Nishida, C. Creminon, D. Casanova, and S. Lehmann (2001)
J. Biol. Chem. 276, 2286-2291
   Abstract »    Full Text »    PDF »
Reconstitution of Prion Infectivity from Solubilized Protease-resistant PrP and Nonprotein Components of Prion Rods.
G. M. Shaked, Z. Meiner, I. Avraham, A. Taraboulos, and R. Gabizon (2001)
J. Biol. Chem. 276, 14324-14328
   Abstract »    Full Text »    PDF »
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt- Jakob disease: Implications for human health.
C. I. Lasmezas, J.-G. Fournier, V. Nouvel, H. Boe, D. Marce, F. Lamoury, N. Kopp, J.-J. Hauw, J. Ironside, M. Bruce, et al. (2001)
PNAS 98, 4142-4147
   Abstract »    Full Text »    PDF »
Prion infection impairs the cellular response to oxidative stress.
O. Milhavet, H. E. M. McMahon, W. Rachidi, N. Nishida, S. Katamine, A. Mange, M. Arlotto, D. Casanova, J. Riondel, A. Favier, et al. (2000)
PNAS 97, 13937-13942
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)