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Science 10 January 1997:
Vol. 275. no. 5297, pp. 224 - 227
DOI: 10.1126/science.275.5297.224
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Reports

Circadian Rhythms in Rapidly Dividing Cyanobacteria

Takao Kondo, * Tetsuya Mori, Nadya V. Lebedeva, Setsuyuki Aoki, Masahiro Ishiura, Susan S. Golden

The long-standing supposition that the biological clock cannot function in cells that divide more rapidly than the circadian cycle was investigated. During exponential growth in which the generation time was 10 hours, the profile of bioluminescence from a reporter strain of the cyanobacterium Synechococcus (species PCC 7942) matched a model based on the assumption that cells proliferate exponentially and the bioluminescence of each cell oscillates in a cosine fashion. Some messenger RNAs showed a circadian rhythm in abundance during continuous exponential growth with a doubling time of 5 to 6 hours. Thus, the cyanobacterial circadian clock functions in cells that divide three or more times during one circadian cycle.

T. Kondo, S. Aoki, M. Ishiura, Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-01 Japan.
T. Mori, Department of Biology, Vanderbilt University, Nashville, TN, 37235, USA.
N. V. Lebedeva and S. S. Golden, Department of Biology, Texas A&M University, College Station, TX, 77843, USA.
*   To whom correspondence should be addressed.

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