Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 January 1997:
Vol. 275. no. 5297, pp. 218 - 220
DOI: 10.1126/science.275.5297.218
Prev | Table of Contents | Next

Reports

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Meishiang Jang, Lining Cai, * George O. Udeani, Karla V. Slowing, Cathy F. Thomas, Christopher W. W. Beecher, Harry H. S. Fong, Norman R. Farnsworth, A. Douglas Kinghorn, Rajendra G. Mehta, Richard C. Moon, John M. Pezzuto dagger

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
G. O. Udeani, Department of Pharmacy Practice, University of Illinois, Chicago, IL 60612, USA.
K. V. Slowing, Departmento de Farmacologia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
C. F. Thomas, R. G. Mehta, R. C. Moon, Department of Surgical Oncology, College of Medicine, University of Illinois, Chicago, IL 60612, USA.
*   Present address: Dows Institute for Dental Research, University of Iowa, Iowa City, IA 52242, USA.

dagger    To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Unraveling the Relationship between Grapes and Health.
J. M. Pezzuto, V. Venkatasubramanian, M. Hamad, and K. R. Morris (2009)
J. Nutr. 139, 1783S-1787S
   Abstract »    Full Text »    PDF »
Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products.
M. Kaur, C. Agarwal, and R. Agarwal (2009)
J. Nutr. 139, 1806S-1812S
   Abstract »    Full Text »    PDF »
Characterizing the Effects of Common UDP Glucuronosyltransferase (UGT) 1A6 and UGT1A1 Polymorphisms on cis- and trans-Resveratrol Glucuronidation.
O. F. Iwuchukwu, J. Ajetunmobi, D. Ung, and S. Nagar (2009)
Drug Metab. Dispos. 37, 1726-1732
   Abstract »    Full Text »    PDF »
Antiproliferative Effects of Resveratrol and the Mediating Role of Resveratrol Targeting Protein NQO2 in Androgen Receptor-positive, Hormone-non-responsive CWR22Rv1 Cells.
T.-C. HSIEH (2009)
Anticancer Res 29, 3011-3017
   Abstract »    Full Text »    PDF »
Mechanisms of resveratrol-induced platelet apoptosis.
K. H. Lin, G. Hsiao, C. M. Shih, D. S. Chou, and J. R. Sheu (2009)
Cardiovasc Res 83, 575-585
   Abstract »    Full Text »    PDF »
The Dietary Polyphenols trans-Resveratrol and Curcumin Selectively Bind Human CB1 Cannabinoid Receptors with Nanomolar Affinities and Function as Antagonists/Inverse Agonists.
K. A. Seely, M. S. Levi, and P. L. Prather (2009)
J. Pharmacol. Exp. Ther. 330, 31-39
   Abstract »    Full Text »    PDF »
Prevention of Ocular Inflammation in Endotoxin-Induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor-{kappa}B Activation.
S. Kubota, T. Kurihara, H. Mochimaru, S. Satofuka, K. Noda, Y. Ozawa, Y. Oike, S. Ishida, and K. Tsubota (2009)
Invest. Ophthalmol. Vis. Sci. 50, 3512-3519
   Abstract »    Full Text »    PDF »
Resveratrol Inhibits Dioxin-Induced Expression of Human CYP1A1 and CYP1B1 by Inhibiting Recruitment of the Aryl Hydrocarbon Receptor Complex and RNA Polymerase II to the Regulatory Regions of the Corresponding Genes.
S. R. Beedanagari, I. Bebenek, P. Bui, and O. Hankinson (2009)
Toxicol. Sci. 110, 61-67
   Abstract »    Full Text »    PDF »
Cancer Prevention: From 1727 to Milestones of the Past 100 Years.
S. M. Lippman and E. T. Hawk (2009)
Cancer Res. 69, 5269-5284
   Abstract »    Full Text »    PDF »
Anti-inflammatory Action of Pterostilbene Is Mediated through the p38 Mitogen-Activated Protein Kinase Pathway in Colon Cancer Cells.
S. Paul, A. M. Rimando, H. J. Lee, Y. Ji, B. S. Reddy, and N. Suh (2009)
Cancer Prevention Research 2, 650-657
   Abstract »    Full Text »    PDF »
From the Cover: The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood.
R. D. Gougeon, M. Lucio, M. Frommberger, D. Peyron, D. Chassagne, H. Alexandre, F. Feuillat, A. Voilley, P. Cayot, I. Gebefugi, et al. (2009)
PNAS 106, 9174-9179
   Abstract »    Full Text »    PDF »
Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia.
N. Bianchi, C. Zuccato, I. Lampronti, M. Borgatti, and R. Gambari (2009)
Evid. Based Complement. Altern. Med. 6, 141-151
   Abstract »    Full Text »    PDF »
Perspectives for Cancer Prevention With Natural Compounds.
A.R.M. R. Amin, O. Kucuk, F. R. Khuri, and D. M. Shin (2009)
J. Clin. Oncol. 27, 2712-2725
   Abstract »    Full Text »    PDF »
Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials.
A. Bishayee (2009)
Cancer Prevention Research 2, 409-418
   Abstract »    Full Text »    PDF »
Food intake, dietary patterns, and actinic keratoses of the skin: a longitudinal study.
M. C. B Hughes, G. M Williams, A. Fourtanier, and A. C Green (2009)
Am. J. Clinical Nutrition 89, 1246-1255
   Abstract »    Full Text »    PDF »
Anti-proliferative and Apoptosis Induction Activity of Green Tea Polyphenols on Human Promyelocytic Leukemia HL-60 Cells.
D. H. HAN, J. H. JEONG, and J. H. KIM (2009)
Anticancer Res 29, 1417-1421
   Abstract »    Full Text »    PDF »
No Difference Between Red Wine or White Wine Consumption and Breast Cancer Risk.
P. A. Newcomb, H. B. Nichols, J. M. Beasley, K. Egan, L. Titus-Ernstoff, J. M. Hampton, and A. Trentham-Dietz (2009)
Cancer Epidemiol. Biomarkers Prev. 18, 1007-1010
   Full Text »    PDF »
Improved Antiulcer and Anticancer Properties of a trans-Resveratrol Analog in Mice.
P. Guha, A. Dey, B. Sarkar, M. V. Dhyani, S. Chattopadhyay, and S. K. Bandyopadhyay (2009)
J. Pharmacol. Exp. Ther. 328, 829-838
   Abstract »    Full Text »    PDF »
Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates {beta}-Catenin Signaling and NF{kappa}B-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells.
L. Y. W. Bourguignon, W. Xia, and G. Wong (2009)
J. Biol. Chem. 284, 2657-2671
   Abstract »    Full Text »    PDF »
Resveratrol Inhibits Tumor Cell Adhesion to Endothelial Cells by Blocking ICAM-1 Expression.
J. S. PARK, K. M. KIM, M. H. KIM, H. J. CHANG, M. K. BAEK, S. M. KIM, and Y. D. JUNG (2009)
Anticancer Res 29, 355-362
   Abstract »    Full Text »    PDF »
Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells.
J. J. Zhang, M. Wu, N. W. Schoene, W.-H. Cheng, T. T. Y. Wang, A. A. Alshatwi, M. Alsaif, and K. Y. Lei (2009)
Am J Physiol Cell Physiol 297, C632-C644
   Abstract »    Full Text »    PDF »
{alpha}v{beta}3 Integrin-dependent antiangiogenic activity of resveratrol stereoisomers.
M. Belleri, D. Ribatti, M. Savio, L. A. Stivala, L. Forti, E. Tanghetti, P. Alessi, D. Coltrini, A. Bugatti, S. Mitola, et al. (2008)
Mol. Cancer Ther. 7, 3761-3770
   Abstract »    Full Text »    PDF »
A Stress-Inducible Resveratrol O-Methyltransferase Involved in the Biosynthesis of Pterostilbene in Grapevine.
L. Schmidlin, A. Poutaraud, P. Claudel, P. Mestre, E. Prado, M. Santos-Rosa, S. Wiedemann-Merdinoglu, F. Karst, D. Merdinoglu, and P. Hugueney (2008)
Plant Physiology 148, 1630-1639
   Abstract »    Full Text »    PDF »
Abstract PL05-03: Influence of Mother Nature's pharmacopeia on everyday health and wellbeing.
J. Pezzuto and K. Morris (2008)
Cancer Prevention Research 1, PL05-03
Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism.
S. Priego, F. Feddi, P. Ferrer, S. Mena, M. Benlloch, A. Ortega, J. Carretero, E. Obrador, M. Asensi, and J. M. Estrela (2008)
Mol. Cancer Ther. 7, 3330-3342
   Abstract »    Full Text »    PDF »
Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B.
B. Venkatesan, N. Ghosh-Choudhury, F. Das, L. Mahimainathan, A. Kamat, B. S. Kasinath, H. E. Abboud, and G. G. Choudhury (2008)
FASEB J 22, 3469-3482
   Abstract »    Full Text »    PDF »
Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo.
T. T.Y. Wang, T. S. Hudson, T.-C. Wang, C. M. Remsberg, N. M. Davies, Y. Takahashi, Y. S. Kim, H. Seifried, B. T. Vinyard, S. N. Perkins, et al. (2008)
Carcinogenesis 29, 2001-2010
   Abstract »    Full Text »    PDF »
Resveratrol Prevents Estrogen-DNA Adduct Formation and Neoplastic Transformation in MCF-10F Cells.
F. Lu, M. Zahid, C. Wang, M. Saeed, E. L. Cavalieri, and E. G. Rogan (2008)
Cancer Prevention Research 1, 135-145
   Abstract »    Full Text »    PDF »
SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells.
R. Miyazaki, T. Ichiki, T. Hashimoto, K. Inanaga, I. Imayama, J. Sadoshima, and K. Sunagawa (2008)
Arterioscler Thromb Vasc Biol 28, 1263-1269
   Abstract »    Full Text »    PDF »
Nutritionally Improved Agricultural Crops.
M. Newell-McGloughlin (2008)
Plant Physiology 147, 939-953
   Full Text »    PDF »
Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats.
C.-C. Lu, H.-C. Lai, S.-C. Hsieh, and J.-K. Chen (2008)
J. Leukoc. Biol. 83, 1028-1037
   Abstract »    Full Text »    PDF »
Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner.
S. A. Gatz, M. Keimling, C. Baumann, T. Dork, K.-M. Debatin, S. Fulda, and L. Wiesmuller (2008)
Carcinogenesis 29, 519-527
   Abstract »    Full Text »    PDF »
A Review of Complementary and Alternative Approaches to Immunomodulation.
J. O. Clarke and G. E. Mullin (2008)
Nutr Clin Pract 23, 49-62
   Abstract »    Full Text »    PDF »
Association of NRH:Quinone Oxidoreductase 2 Gene Promoter Polymorphism With Higher Gene Expression and Increased Susceptibility to Parkinson's Disease.
W. Wang, W.-D. Le, T. Pan, J. L. Stringer, and A. K. Jaiswal (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 127-134
   Abstract »    Full Text »    PDF »
Resveratrol (trans-Resveratrol, 3,5,4'-Trihydroxy-trans-stilbene) Glucuronidation Exhibits Atypical Enzyme Kinetics in Various Protein Sources.
O. F. Iwuchukwu and S. Nagar (2008)
Drug Metab. Dispos. 36, 322-330
   Abstract »    Full Text »    PDF »
Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes.
N. F. Trincheri, C. Follo, G. Nicotra, C. Peracchio, R. Castino, and C. Isidoro (2008)
Carcinogenesis 29, 381-389
   Abstract »    Full Text »    PDF »
Take a break--resveratrol in action on DNA.
S. A. Gatz and L. Wiesmuller (2008)
Carcinogenesis 29, 321-332
   Abstract »    Full Text »    PDF »
Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated.
H.-Y. Lin, H.-Y. Tang, T. Keating, Y.-H. Wu, A. Shih, D. Hammond, M. Sun, A. Hercbergs, F. B. Davis, and P. J. Davis (2008)
Carcinogenesis 29, 62-69
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Resveratrol Action in Lung Cancer Cells Using Dual Protein and Microarray Analyses.
L. Whyte, Y.-Y. Huang, K. Torres, and R. G. Mehta (2007)
Cancer Res. 67, 12007-12017
   Abstract »    Full Text »    PDF »
Mitochondria, Calcium, and Calpain are Key Mediators of Resveratrol-Induced Apoptosis in Breast Cancer.
D. Sareen, S. R. Darjatmoko, D. M. Albert, and A. S. Polans (2007)
Mol. Pharmacol. 72, 1466-1475
   Abstract »    Full Text »    PDF »
Resveratrol (trans-3,5,4'-Trihydroxystilbene) Ameliorates Experimental Allergic Encephalomyelitis, Primarily via Induction of Apoptosis in T Cells Involving Activation of Aryl Hydrocarbon Receptor and Estrogen Receptor.
N. P. Singh, V. L. Hegde, L. J. Hofseth, M. Nagarkatti, and P. Nagarkatti (2007)
Mol. Pharmacol. 72, 1508-1521
   Abstract »    Full Text »    PDF »
Reactive Oxygen Species Regulate Angiogenesis and Tumor Growth through Vascular Endothelial Growth Factor.
C. Xia, Q. Meng, L.-Z. Liu, Y. Rojanasakul, X.-R. Wang, and B.-H. Jiang (2007)
Cancer Res. 67, 10823-10830
   Abstract »    Full Text »    PDF »
Role of nutrition in preventing cancer.
R. Beliveau and D. Gingras (2007)
Can Fam Physician 53, 1905-1911
   Abstract »    Full Text »    PDF »
Clusterin mediates TRAIL resistance in prostate tumor cells.
D. A. Sallman, X. Chen, B. Zhong, D. L. Gilvary, J. Zhou, S. Wei, and J. Y. Djeu (2007)
Mol. Cancer Ther. 6, 2938-2947
   Abstract »    Full Text »    PDF »
Resveratrol, a Component of Red Wine, Elicits Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and Potassium Channels.
T. Nagaoka, T. W. Hein, A. Yoshida, and L. Kuo (2007)
Invest. Ophthalmol. Vis. Sci. 48, 4232-4239
   Abstract »    Full Text »    PDF »
Resveratrol suppresses prostate cancer progression in transgenic mice.
C. E. Harper, B. B. Patel, J. Wang, A. Arabshahi, I. A. Eltoum, and C. A. Lamartiniere (2007)
Carcinogenesis 28, 1946-1953
   Abstract »    Full Text »    PDF »
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.
K. W. Lee, N. J. Kang, E. A. Rogozin, H.-G. Kim, Y. Y. Cho, A. M. Bode, H. J. Lee, Y.-J. Surh, G. T. Bowden, and Z. Dong (2007)
Carcinogenesis 28, 1918-1927
   Abstract »    Full Text »    PDF »
Resveratrol Inhibits Tumor Growth of Human Neuroblastoma and Mediates Apoptosis by Directly Targeting Mitochondria.
P. R. van Ginkel, D. Sareen, L. Subramanian, Q. Walker, S. R. Darjatmoko, M. J. Lindstrom, A. Kulkarni, D. M. Albert, and A. S. Polans (2007)
Clin. Cancer Res. 13, 5162-5169
   Abstract »    Full Text »    PDF »
Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol.
J.-L. Su, C.-Y. Yang, M. Zhao, M.-L. Kuo, and M.-L. Yen (2007)
J. Biol. Chem. 282, 19385-19398
   Abstract »    Full Text »    PDF »
Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent.
D. J. Boocock, G. E.S. Faust, K. R. Patel, A. M. Schinas, V. A. Brown, M. P. Ducharme, T. D. Booth, J. A. Crowell, M. Perloff, A. J. Gescher, et al. (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 1246-1252
   Abstract »    Full Text »    PDF »
Chronic Resveratrol Enhances Endothelium-Dependent Relaxation but Does Not Alter eNOS Levels in Aorta of Spontaneously Hypertensive Rats.
J. W. E. Rush, J. Quadrilatero, A. S. Levy, and R. J. Ford (2007)
Experimental Biology and Medicine 232, 814-822
   Abstract »    Full Text »    PDF »
Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells.
L. Nonn, D. Duong, and D. M. Peehl (2007)
Carcinogenesis 28, 1188-1196
   Abstract »    Full Text »    PDF »
Cyanidin-3-rutinoside, a Natural Polyphenol Antioxidant, Selectively Kills Leukemic Cells by Induction of Oxidative Stress.
R. Feng, H.-M. Ni, S. Y. Wang, I. L. Tourkova, M. R. Shurin, H. Harada, and X.-M. Yin (2007)
J. Biol. Chem. 282, 13468-13476
   Abstract »    Full Text »    PDF »
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D.
N. F. Trincheri, G. Nicotra, C. Follo, R. Castino, and C. Isidoro (2007)
Carcinogenesis 28, 922-931
   Abstract »    Full Text »    PDF »
Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Hypoxia-Inducible Factor 1{alpha} Protein Accumulation and Vascular Endothelial Growth Factor Expression in Human Cervical Carcinoma Cells.
X. Tang, Q. Zhang, J. Nishitani, J. Brown, S. Shi, and A. D. Le (2007)
Clin. Cancer Res. 13, 2568-2576
   Abstract »    Full Text »    PDF »
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
A. Bhardwaj, G. Sethi, S. Vadhan-Raj,, C. Bueso-Ramos, Y. Takada, U. Gaur, A. S. Nair, S. Shishodia, and B. B. Aggarwal (2007)
Blood 109, 2293-2302
   Abstract »    Full Text »    PDF »
Mechanisms Involved in Resveratrol-Induced Apoptosis and Cell Cycle Arrest in Prostate Cancer-Derived Cell Lines.
D. A. Benitez, E. Pozo-Guisado, A. Alvarez-Barrientos, P. M. Fernandez-Salguero, and E. A. Castellon (2007)
J Androl 28, 282-293
   Abstract »    Full Text »    PDF »
Nitric Oxide Mediates Natural Polyphenol-induced Bcl-2 Down-regulation and Activation of Cell Death in Metastatic B16 Melanoma.
P. Ferrer, M. Asensi, S. Priego, M. Benlloch, S. Mena, A. Ortega, E. Obrador, J. M. Esteve, and J. M. Estrela (2007)
J. Biol. Chem. 282, 2880-2890
   Abstract »    Full Text »    PDF »
Pterostilbene, an Active Constituent of Blueberries, Suppresses Aberrant Crypt Foci Formation in the Azoxymethane-Induced Colon Carcinogenesis Model in Rats.
N. Suh, S. Paul, X. Hao, B. Simi, H. Xiao, A. M. Rimando, and B. S. Reddy (2007)
Clin. Cancer Res. 13, 350-355
   Abstract »    Full Text »    PDF »
Phytoestrogens and breast cancer -promoters or protectors?.
S. Rice and S. A Whitehead (2006)
Endocr. Relat. Cancer 13, 995-1015
   Abstract »    Full Text »    PDF »
Characterization of the Substrate Specificity of PhlD, a Type III Polyketide Synthase from Pseudomonas fluorescens.
W. Zha, S. B. Rubin-Pitel, and H. Zhao (2006)
J. Biol. Chem. 281, 32036-32047
   Abstract »    Full Text »    PDF »
Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities.
E.-O. Lee, H.-J. Lee, H.-S. Hwang, K.-S. Ahn, C. Chae, K.-S. Kang, J. Lu, and S.-H. Kim (2006)
Carcinogenesis 27, 2059-2069
   Abstract »    Full Text »    PDF »
Resveratrol Is Rapidly Metabolized in Athymic (Nu/Nu) Mice and Does Not Inhibit Human Melanoma Xenograft Tumor Growth.
R. M. Niles, C. P. Cook, G. G. Meadows, Y.-M. Fu, J. L. McLaughlin, and G. O. Rankin (2006)
J. Nutr. 136, 2542-2546
   Abstract »    Full Text »    PDF »
Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells..
D. Sareen, P. R. van Ginkel, J. C. Takach, A. Mohiuddin, S. R. Darjatmoko, D. M. Albert, and A. S. Polans (2006)
Invest. Ophthalmol. Vis. Sci. 47, 3708-3716
   Abstract »    Full Text »    PDF »
Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells.
C. Guichard, E. Pedruzzi, M. Fay, J.-C. Marie, F. Braut-Boucher, F. Daniel, A. Grodet, M.-A. Gougerot-Pocidalo, E. Chastre, L. Kotelevets, et al. (2006)
Carcinogenesis 27, 1812-1827
   Abstract »    Full Text »    PDF »
Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells..
H.-Y. Tang, A. Shih, H. J. Cao, F. B. Davis, P. J. Davis, and H.-Y. Lin (2006)
Mol. Cancer Ther. 5, 2034-2042
   Abstract »    Full Text »    PDF »
Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids.
P. A. Tsuji and T. Walle (2006)
Carcinogenesis 27, 1579-1585
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-Activated Receptor {gamma} as a Molecular Target of Resveratrol-Induced Modulation of Polyamine Metabolism..
S. Ulrich, S. M. Loitsch, O. Rau, A. von Knethen, B. Brune, M. Schubert-Zsilavecz, and J. M. Stein (2006)
Cancer Res. 66, 7348-7354
   Abstract »    Full Text »    PDF »
Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-{kappa}B in mouse skin by blocking I{kappa}B kinase activity.
J. K. Kundu, Y. K. Shin, S. H. Kim, and Y.-J. Surh (2006)
Carcinogenesis 27, 1465-1474
   Abstract »    Full Text »    PDF »
Resveratrol Suppresses Tumor Necrosis Factor-{alpha}-Induced Fractalkine Expression in Endothelial Cells.
S.-O. Moon, W. Kim, M. J. Sung, S. Lee, K. P. Kang, D. H. Kim, S. Y. Lee, J.-N. So, and S. K. Park (2006)
Mol. Pharmacol. 70, 112-119
   Abstract »    Full Text »    PDF »
Caspase-2 Triggers Bax-Bak-dependent and -independent Cell Death in Colon Cancer Cells Treated with Resveratrol.
J. Mohan, A. A. Gandhi, B. C. Bhavya, R. Rashmi, D. Karunagaran, R. Indu, and T. R. Santhoshkumar (2006)
J. Biol. Chem. 281, 17599-17611
   Abstract »    Full Text »    PDF »
Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats.
H.-C. Su, L.-M. Hung, and J.-K. Chen (2006)
Am J Physiol Endocrinol Metab 290, E1339-E1346
   Abstract »    Full Text »    PDF »
Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins.
M. H. Aziz, M. Nihal, V. X. Fu, D. F. Jarrard, and N. Ahmad (2006)
Mol. Cancer Ther. 5, 1335-1341
   Abstract »    Full Text »    PDF »
Chemopreventive effect of trans-resveratrol - a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis.
M. Sengottuvelan, P. Viswanathan, and N. Nalini (2006)
Carcinogenesis 27, 1038-1046
   Abstract »    Full Text »    PDF »
Resveratrol in cardioprotection: a therapeutic promise of alternative medicine..
D. K. Das and N. Maulik (2006)
Mol. Interv. 6, 36-47
   Abstract »    Full Text »    PDF »
Resveratrol Inhibits TNF-{alpha}-Induced Proliferation and Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells.
B. Lee and S.-K. Moon (2005)
J. Nutr. 135, 2767-2773
   Abstract »    Full Text »    PDF »
Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals.
Y.-J. Surh, J. K. Kundu, H.-K. Na, and J.-S. Lee (2005)
J. Nutr. 135, 2993S-3001S
   Abstract »    Full Text »    PDF »
Resveratrol Inhibits Myeloma Cell Growth, Prevents Osteoclast Formation, and Promotes Osteoblast Differentiation.
P. Boissy, T. L. Andersen, B. M. Abdallah, M. Kassem, T. Plesner, and J.-M. Delaisse (2005)
Cancer Res. 65, 9943-9952
   Abstract »    Full Text »    PDF »
Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.
A. Tyagi, R. P. Singh, C. Agarwal, S. Siriwardana, R. A. Sclafani, and R. Agarwal (2005)
Carcinogenesis 26, 1978-1987
   Abstract »    Full Text »    PDF »
Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1{alpha} and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells.
Q. Zhang, X. Tang, Q. Y. Lu, Z. F. Zhang, J. Brown, and A. D. Le (2005)
Mol. Cancer Ther. 4, 1465-1474
   Abstract »    Full Text »    PDF »
Human Fecal Water Inhibits COX-2 in Colonic HT-29 Cells: Role of Phenolic Compounds.
P. C. Karlsson, U. Huss, A. Jenner, B. Halliwell, L. Bohlin, and J. J. Rafter (2005)
J. Nutr. 135, 2343-2349
   Abstract »    Full Text »    PDF »
Design of a Small-Molecule Entry Inhibitor with Activity against Primary Measles Virus Strains.
R. K. Plemper, J. Doyle, A. Sun, A. Prussia, L.-T. Cheng, P. A. Rota, D. C. Liotta, J. P. Snyder, and R. W. Compans (2005)
Antimicrob. Agents Chemother. 49, 3755-3761
   Abstract »    Full Text »    PDF »
Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex.
H. S. Youn, J. Y. Lee, K. A. Fitzgerald, H. A. Young, S. Akira, and D. H. Hwang (2005)
J. Immunol. 175, 3339-3346
   Abstract »    Full Text »    PDF »
Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes.
J. W. Fahey, K. K. Stephenson, A. T. Dinkova-Kostova, P. A. Egner, T. W. Kensler, and P. Talalay (2005)
Carcinogenesis 26, 1247-1255
   Abstract »    Full Text »    PDF »
Phytoestrogen exposure elevates PTEN levels.
K. A. Waite, M. R. Sinden, and C. Eng (2005)
Hum. Mol. Genet. 14, 1457-1463
   Abstract »    Full Text »    PDF »
Quercetin Attenuates Nuclear Factor-{kappa}B Activation and Nitric Oxide Production in Interleukin-1{beta}-Activated Rat Hepatocytes.
S. Martinez-Florez, B. Gutierrez-Fernandez, S. Sanchez-Campos, J. Gonzalez-Gallego, and M. J. Tunon (2005)
J. Nutr. 135, 1359-1365
   Abstract »    Full Text »    PDF »
Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4'-Trimethoxystilbene.
M. Belleri, D. Ribatti, S. Nicoli, F. Cotelli, L. Forti, V. Vannini, L. A. Stivala, and M. Presta (2005)
Mol. Pharmacol. 67, 1451-1459
   Abstract »    Full Text »    PDF »
Resveratrol-induced apoptotic death in human U251 glioma cells.
H. Jiang, L. Zhang, J. Kuo, K. Kuo, S. C. Gautam, L. Groc, A. I. Rodriguez, D. Koubi, T. Jackson Hunter, G. B. Corcoran, et al. (2005)
Mol. Cancer Ther. 4, 554-561
   Abstract »    Full Text »    PDF »
Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells.
J.-L. Su, M.-T. Lin, C.-C. Hong, C.-C. Chang, S.-G. Shiah, C.-W. Wu, S.-T. Chen, Y.-P. Chau, and M.-L. Kuo (2005)
Carcinogenesis 26, 1-10
   Abstract »    Full Text »    PDF »
Effect of Black Tea Intake on the Excretion of Mutagens in the Urine of Volunteers Taking a Beef Meal.
V. R. Yoxall, J. Bishop, and C. Ioannides (2004)
Cancer Epidemiol. Biomarkers Prev. 13, 2196-2202
   Abstract »    Full Text »    PDF »
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS.
T. Walle, F. Hsieh, M. H. DeLegge, J. E. Oatis Jr., and U. K. Walle (2004)
Drug Metab. Dispos. 32, 1377-1382
   Abstract »    Full Text »    PDF »
Resveratrol-Associated Renal Toxicity.
J. A. Crowell, P. J. Korytko, R. L. Morrissey, T. D. Booth, and B. S. Levine (2004)
Toxicol. Sci. 82, 614-619
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of the Chemopreventive Effects of Resveratrol and Its Analogs in Colorectal Cancer: Key Role of Polyamines?.
F. Wolter, S. Ulrich, and J. Stein (2004)
J. Nutr. 134, 3219-3222
   Abstract »    Full Text »    PDF »
Wine Consumption and Epithelial Ovarian Cancer.
S. C. Larsson, A. Wolk, P. M. Webb, D. M. Purdie, C. J. Bain, and A. C. Green (2004)
Cancer Epidemiol. Biomarkers Prev. 13, 1823-1824
   Full Text »    PDF »
Type of wine and risk of lung cancer: a case-control study in Spain.
A Ruano-Ravina, A Figueiras, and J M Barros-Dios (2004)
Thorax 59, 981-985
   Abstract »    Full Text »    PDF »
Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-{alpha}.
A. Shih, S. Zhang, H. J. Cao, S. Boswell, Y.-H. Wu, H.-Y. Tang, M. R. Lennartz, F. B. Davis, P. J. Davis, and H.-Y. Lin (2004)
Mol. Cancer Ther. 3, 1355-1364
   Abstract »    Full Text »    PDF »
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.
Z.-H. Chen, Y.-J. Hurh, H.-K. Na, J.-H. Kim, Y.-J. Chun, D.-H. Kim, K.-S. Kang, M.-H. Cho, and Y.-J. Surh (2004)
Carcinogenesis 25, 2005-2013
   Abstract »    Full Text »    PDF »
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.
L. E. Donnelly, R. Newton, G. E. Kennedy, P. S. Fenwick, R. H. F. Leung, K. Ito, R. E. K. Russell, and P. J. Barnes (2004)
Am J Physiol Lung Cell Mol Physiol 287, L774-L783
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)