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Science 10 January 1997:
Vol. 275. no. 5297, pp. 213 - 215
DOI: 10.1126/science.275.5297.213
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Reports

Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

Henry Markram, * Joachim Lübke, Michael Frotscher, Bert Sakmann

Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning. In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs. Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs. These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neurons.

H. Markram and B. Sakmann, Max-Planck-Institut für Medizinische Forschung, Abteilung Zellphysiologie, Jahnstraße 29, D-69120 Heidelberg, Germany.
J. Lübke and M. Frotscher, Anatomisches Institut der Albert-Ludwigs Universität Freiburg, Albertstraße 17, D-79104 Freiburg, Germany.
*   To whom correspondence should be addressed at the Department of Neurobiology, Weizmann Institute for Science, Rehovot, 76100, Israel. E-mail: bnmark{at}weizmann.weizmann.ac.il

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