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Science 10 January 1997:
Vol. 275. no. 5297, pp. 206 - 209
DOI: 10.1126/science.275.5297.206
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Reports

Activation of Interferon-gamma Inducing Factor Mediated by Interleukin-1beta Converting Enzyme

Yong Gu, Keisuke Kuida, Hiroko Tsutsui, George Ku, Kathy Hsiao, Mark A. Fleming, Nobuki Hayashi, Kazuya Higashino, Haruki Okamura, Kenji Nakanishi, Masashi Kurimoto, Tadao Tanimoto, Richard A. Flavell, Vicki Sato, Matthew W. Harding, David J. Livingston, Michael S.-S. Su

The interleukin-1beta (IL-1beta ) converting enzyme (ICE) processes the inactive IL-1beta precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE-/-) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE-/- mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE-/- mice may account for their protection from septic shock.

Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
K. Kuida, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
H. Tsutsui, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Japan.
M. Kurimoto and T. Tanimoto, Fujisaki Institute, Hayashibara Biochemical Laboratories, Hayashibara Company Inc., Okayama, Japan.
R. A. Flavell, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

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Effect of {beta}2-Adrenergic Receptor Stimulation on Interleukin-18-Induced Intercellular Adhesion Molecule-1 Expression and Cytokine Production.
H. K. Takahashi, T. Morichika, H. Iwagaki, T. Yoshino, R. Tamura, S. Saito, S. Mori, T. Akagi, N. Tanaka, and M. Nishibori (2003)
J. Pharmacol. Exp. Ther. 304, 634-642
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Differential Cytokine Responses following Marek's Disease Virus Infection of Chickens Differing in Resistance to Marek's Disease.
P. Kaiser, G. Underwood, and F. Davison (2002)
J. Virol. 77, 762-768
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Mycobacterium bovis BCG Producing Interleukin-18 Increases Antigen-Specific Gamma Interferon Production in Mice.
F. Biet, L. Kremer, I. Wolowczuk, M. Delacre, and C. Locht (2002)
Infect. Immun. 70, 6549-6557
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Role of Caspase 1 in Murine Antibacterial Host Defenses and Lethal Endotoxemia.
V. D. Joshi, D. V. Kalvakolanu, J. R. Hebel, J. D. Hasday, and A. S. Cross (2002)
Infect. Immun. 70, 6896-6903
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Interleukin-18 and Gamma Interferon Production by Oral Epithelial Cells in Response to Exposure to Candida albicans or Lipopolysaccharide Stimulation.
M. Rouabhia, G. Ross, N. Page, and J. Chakir (2002)
Infect. Immun. 70, 7073-7080
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Elevated Levels of Circulating Interleukin-18 in Human Immunodeficiency Virus-Infected Individuals: Role of Peripheral Blood Mononuclear Cells and Implications for AIDS Pathogenesis.
R. Ahmad, S. T. A. Sindhu, E. Toma, R. Morisset, and A. Ahmad (2002)
J. Virol. 76, 12448-12456
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Caspase-11 Gene Expression in Response to Lipopolysaccharide and Interferon-gamma Requires Nuclear Factor-kappa B and Signal Transducer and Activator of Transcription (STAT) 1.
R. Schauvliege, J. Vanrobaeys, P. Schotte, and R. Beyaert (2002)
J. Biol. Chem. 277, 41624-41630
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Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells.
D. Dreher, M. Kok, C. Obregon, S. G. Kiama, P. Gehr, and L. P. Nicod (2002)
J. Leukoc. Biol. 72, 743-751
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IL-18 Levels and the Outcome of Innate Immune Response to Lipopolysaccharide: Importance of a Positive Feedback Loop with Caspase-1 in IL-18 Expression.
V. D. Joshi, D. V. Kalvakolanu, J. D. Hasday, R. J. Hebel, and A. S. Cross (2002)
J. Immunol. 169, 2536-2544
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IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions.
H. Konishi, H. Tsutsui, T. Murakami, S. Yumikura-Futatsugi, K.-i. Yamanaka, M. Tanaka, Y. Iwakura, N. Suzuki, K. Takeda, S. Akira, et al. (2002)
PNAS 99, 11340-11345
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Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction.
C. D. Raeburn, C. A. Dinarello, M. A. Zimmerman, C. M. Calkins, B. J. Pomerantz, R. C. McIntyre Jr., A. H. Harken, and X. Meng (2002)
Am J Physiol Heart Circ Physiol 283, H650-H657
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Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage.
P V Sivakumar, G M Westrich, S Kanaly, K Garka, T L Born, J M J Derry, and J L Viney (2002)
Gut 50, 812-820
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IL-18 Contributes to Host Resistance Against Infection with Pseudomonas aeruginosa Through Induction of IFN-{gamma} Production.
X. Huang, S. A. McClellan, R. P. Barrett, and L. D. Hazlett (2002)
J. Immunol. 168, 5756-5763
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Listeria monocytogenes Infection in Caspase-11-Deficient Mice.
N. J. Mueller, R. A. Wilkinson, and J. A. Fishman (2002)
Infect. Immun. 70, 2657-2664
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Prostaglandin E2 Inhibits IL-18-Induced ICAM-1 and B7.2 Expression Through EP2/EP4 Receptors in Human Peripheral Blood Mononuclear Cells.
H. K. Takahashi, H. Iwagaki, T. Yoshino, S. Mori, T. Morichika, H. Itoh, M. Yokoyama, S. Kubo, E. Kondo, T. Akagi, et al. (2002)
J. Immunol. 168, 4446-4454
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The Role of IL-18 in Blood-Stage Immunity Against Murine Malaria Plasmodium yoelii265 and Plasmodium bergheiANKA.
R. P. Singh, S.-i. Kashiwamura, P. Rao, H. Okamura, A. Mukherjee, and V. S. Chauhan (2002)
J. Immunol. 168, 4674-4681
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A Role for IL-15 in Driving the Onset of Spontaneous Autoimmune Thyroiditis?.
P. Kaiser, L. Rothwell, D. Vasicek, and K. Hala (2002)
J. Immunol. 168, 4216-4220
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CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis.
M. Razmara, S. M. Srinivasula, L. Wang, J.-L. Poyet, B. J. Geddes, P. S. DiStefano, J. Bertin, and E. S. Alnemri (2002)
J. Biol. Chem. 277, 13952-13958
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Contribution of Langerhans Cell-Derived IL-18 to Contact Hypersensitivity.
B. Wang, C. Feliciani, B. G. Howell, I. Freed, Q. Cai, H. Watanabe, and D. N. Sauder (2002)
J. Immunol. 168, 3303-3308
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Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E-/- Mice Through Release of Interferon-{gamma}.
S. C. Whitman, P. Ravisankar, and A. Daugherty (2002)
Circ. Res. 90 , e34-e38
   Abstract »    Full Text »    PDF »
Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages: Implications for Atherogenesis.
N. Gerdes, G. K. Sukhova, P. Libby, R. S. Reynolds, J. L. Young, and U. Schonbeck (2002)
J. Exp. Med. 195, 245-257
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