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Science 3 January 1997:
Vol. 275. no. 5296, pp. 90 - 94
DOI: 10.1126/science.275.5296.90
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Reports

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Hidenori Ichijo, * Eisuke Nishida, Kenji Irie, Peter ten Dijke, Masao Saitoh, Tetsuo Moriguchi, Minoru Takagi, Kunihiro Matsumoto, Kohei Miyazono, Yukiko Gotoh

Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including growth factors and environmental stresses. A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. Overexpression of ASK1 induced apoptotic cell death, and ASK1 was activated in cells treated with tumor necrosis factor-alpha (TNF-alpha ). Moreover, TNF-alpha -induced apoptosis was inhibited by a catalytically inactive form of ASK1. ASK1 may be a key element in the mechanism of stress- and cytokine-induced apoptosis.

H. Ichijo, M. Saitoh, K. Miyazono, Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan.
E. Nishida, T. Moriguchi, Y. Gotoh, Department of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-01, Japan.
K. Irie and K. Matsumoto, Department of Molecular Biology, Faculty of Science, Nagoya University, Chikusa-ku, Nagoya 464-01, Japan.
P. ten Dijke, Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S-751 24, Uppsala, Sweden.
M. Takagi, Department of Oral Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors.
T. A. Navas, M. Mohindru, M. Estes, J. Y. Ma, L. Sokol, P. Pahanish, S. Parmar, E. Haghnazari, L. Zhou, R. Collins, et al. (2006)
Blood 108, 4170-4177
   Abstract »    Full Text »    PDF »
Small Heat-Shock Protein Hsp20 Attenuates {beta}-Agonist-Mediated Cardiac Remodeling Through Apoptosis Signal-Regulating Kinase 1.
G.-C. Fan, Q. Yuan, G. Song, Y. Wang, G. Chen, J. Qian, X. Zhou, Y. J. Lee, M. Ashraf, and E. G. Kranias (2006)
Circ. Res. 99, 1233-1242
   Abstract »    Full Text »    PDF »
Inhibition of p38 Mitogen-Activated Protein Kinase and Transforming Growth Factor-{beta}1/Smad Signaling Pathways Modulates the Development of Fibrosis in Adriamycin-Induced Nephropathy.
J. Li, N. V. Campanale, R. J. Liang, J. A. Deane, J. F. Bertram, and S. D. Ricardo (2006)
Am. J. Pathol. 169, 1527-1540
   Abstract »    Full Text »    PDF »
E2F1 Modulates p38 MAPK Phosphorylation via Transcriptional Regulation of ASK1 and Wip1.
T. Hershko, K. Korotayev, S. Polager, and D. Ginsberg (2006)
J. Biol. Chem. 281, 31309-31316
   Abstract »    Full Text »    PDF »
MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells.
R. Padda, A. Wamsley-Davis, M. C. Gustin, R. Ross, C. Yu, and D. Sheikh-Hamad (2006)
Am J Physiol Renal Physiol 291, F874-F881
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Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-{kappa}B Activation: TAO2 REGULATES TAK1 PATHWAYS.
W.-C. HuangFu, E. Omori, S. Akira, K. Matsumoto, and J. Ninomiya-Tsuji (2006)
J. Biol. Chem. 281, 28802-28810
   Abstract »    Full Text »    PDF »
TNF receptor superfamily-induced cell death: redox-dependent execution.
H.-M. Shen and S. Pervaiz (2006)
FASEB J 20, 1589-1598
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JNK- and p38 Kinase-mediated Phosphorylation of Bax Leads to Its Activation and Mitochondrial Translocation and to Apoptosis of Human Hepatoma HepG2 Cells.
B.-J. Kim, S.-W. Ryu, and B.-J. Song (2006)
J. Biol. Chem. 281, 21256-21265
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Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione S-Transferase Pi/c-Jun NH2-Terminal Kinase Complex..
Y.-J. Kim, W.-S. Lee, C. Ip, H.-Z. Chae, E.-M. Park, and Y.-M. Park (2006)
Cancer Res. 66, 7136-7142
   Abstract »    Full Text »    PDF »
Role of the p38 Mitogen-Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide-Dependent Cellular Responses..
N. Giafis, E. Katsoulidis, A. Sassano, M. S. Tallman, L. S. Higgins, A. R. Nebreda, R. J. Davis, and L. C. Platanias (2006)
Cancer Res. 66, 6763-6771
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Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells.
T. Yokoi, K. Fukuo, O. Yasuda, M. Hotta, J. Miyazaki, Y. Takemura, H. Kawamoto, H. Ichijo, and T. Ogihara (2006)
Diabetes 55, 1660-1665
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Platelet-Activating Factor-Induced Clathrin-Mediated Endocytosis Requires beta-Arrestin-1 Recruitment and Activation of the p38 MAPK Signalosome at the Plasma Membrane for Actin Bundle Formation..
N. J. D. McLaughlin, A. Banerjee, M. R. Kelher, F. Gamboni-Robertson, C. Hamiel, F. R. Sheppard, E. E. Moore, and C. C. Silliman (2006)
J. Immunol. 176, 7039-7050
   Abstract »    Full Text »    PDF »
Direct Interaction and Reciprocal Regulation between ASK1 and Calcineurin-NFAT Control Cardiomyocyte Death and Growth.
Q. Liu, B. J. Wilkins, Y. J. Lee, H. Ichijo, and J. D. Molkentin (2006)
Mol. Cell. Biol. 26, 3785-3797
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Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling..
K. Imoto, D. Kukidome, T. Nishikawa, T. Matsuhisa, K. Sonoda, K. Fujisawa, M. Yano, H. Motoshima, T. Taguchi, K. Tsuruzoe, et al. (2006)
Diabetes 55, 1197-1204
   Abstract »    Full Text »    PDF »
Angiotensin II and Stretch Activate NADPH Oxidase to Destabilize Cardiac Kv4.3 Channel mRNA.
C. Zhou, C. Ziegler, L. A. Birder, A. F.R. Stewart, and E. S. Levitan (2006)
Circ. Res. 98, 1040-1047
   Abstract »    Full Text »    PDF »
Prostate-derived Sterile 20-like Kinase 2 (PSK2) Regulates Apoptotic Morphology via C-Jun N-terminal Kinase and Rho Kinase-1.
C. Zihni, C. Mitsopoulos, I. A. Tavares, A. J. Ridley, and J. D. H. Morris (2006)
J. Biol. Chem. 281, 7317-7323
   Abstract »    Full Text »    PDF »
Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells.
D. Xiao and S. V. Singh (2006)
Carcinogenesis 27, 533-540
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Induction of Apoptosis by the Ste20-like Kinase SLK, a Germinal Center Kinase That Activates Apoptosis Signal-regulating Kinase and p38.
W. Hao, T. Takano, J. Guillemette, J. Papillon, G. Ren, and A. V. Cybulsky (2006)
J. Biol. Chem. 281, 3075-3084
   Abstract »    Full Text »    PDF »
Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.
C.-C. Hsieh and J. Papaconstantinou (2006)
FASEB J 20, 259-268
   Abstract »    Full Text »    PDF »
Cationic liposomes induce apoptosis through p38 MAP kinase-caspase-8-Bid pathway in macrophage-like RAW264.7 cells.
S. Iwaoka, T. Nakamura, S. Takano, S. Tsuchiya, and Y. Aramaki (2006)
J. Leukoc. Biol. 79, 184-191
   Abstract »    Full Text »    PDF »
Role of Apoptosis Signal-Regulating Kinase 1 in Stress-Induced Neural Cell Apoptosis in Vivo.
C. Harada, K. Nakamura, K. Namekata, A. Okumura, Y. Mitamura, Y. Iizuka, K. Kashiwagi, K. Yoshida, S. Ohno, A. Matsuzawa, et al. (2006)
Am. J. Pathol. 168, 261-269
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Enhanced TNF-{alpha}-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1.
K. Bijangi-Vishehsaraei, M. R. Saadatzadeh, A. Werne, K. A. W. McKenzie, R. Kapur, H. Ichijo, and L. S. Haneline (2005)
Blood 106, 4124-4130
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Arachidonic Acid Inhibits the Insulin Induction of Glucose-6-phosphate Dehydrogenase via p38 MAP Kinase.
I. Talukdar, W. Szeszel-Fedorowicz, and L. M. Salati (2005)
J. Biol. Chem. 280, 40660-40667
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Generation and Characterization of p38{beta} (MAPK11) Gene-Targeted Mice.
V. A. Beardmore, H. J. Hinton, C. Eftychi, M. Apostolaki, M. Armaka, J. Darragh, J. McIlrath, J. M. Carr, L. J. Armit, C. Clacher, et al. (2005)
Mol. Cell. Biol. 25, 10454-10464
   Abstract »    Full Text »    PDF »
Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death.
T. Noguchi, K. Takeda, A. Matsuzawa, K. Saegusa, H. Nakano, J. Gohda, J.-i. Inoue, and H. Ichijo (2005)
J. Biol. Chem. 280, 37033-37040
   Abstract »    Full Text »    PDF »
Signal Pathway of Hypoxia-Inducible Factor-1{alpha} Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells.
S. J. Kwon, J. J. Song, and Y. J. Lee (2005)
Clin. Cancer Res. 11, 7607-7613
   Abstract »    Full Text »    PDF »


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