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Science 3 January 1997:
Vol. 275. no. 5296, pp. 88 - 90
DOI: 10.1126/science.275.5296.88
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Reports

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

Farid F. Chehab, * Khalid Mounzih, Ronghua Lu, Mary E. Lim

Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract.

Department of Laboratory Medicine, University of California, 505 Parnassus Avenue, San Francisco, CA 94143-0134, USA.
*   To whom correspondence should be addressed.

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A Longitudinal Study of Leptin During Development in the Male Rhesus Monkey: The Effect of Body Composition and Season on Circulating Leptin Levels.
D. R. Mann, M. A. Akinbami, K. G. Gould, and V. D. Castracane (2000)
Biol Reprod 62, 285-291
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Estrogen and Leptin Have Differential Effects on FSH and LH Release in Female Rats.
A. Walczewska, W. H. Yu, S. Karanth, and S. M. McCann (1999)
Experimental Biology and Medicine 222, 170-177
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Ovulation in Plasminogen-Deficient Mice.
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Endocrinology 140, 5030-5035
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Developmental Changes in Long-Form Leptin Receptor Expression and Localization in Rat Brain.
J. Matsuda, I. Yokota, Y. Tsuruo, T. Murakami, K. Ishimura, K. Shima, and Y. Kuroda (1999)
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Episodic leptin release is independent of luteinizing hormone secretion.
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P. Magni, R. Vettor, C. Pagano, A. Calcagno, E. Beretta, E. Messi, M. Zanisi, L. Martini, and M. Motta (1999)
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M. L. Ahmed, K. K. L. Ong, D. J. Morrell, L. Cox, N. Drayer, L. Perry, M. A. Preece, and D. B. Dunger (1999)
J. Clin. Endocrinol. Metab. 84, 899-905
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Biol Reprod 60, 216-222
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Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats.
M Barbier, C Cherbut, A C Aube, H M Blottiere, and J P Galmiche (1998)
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Intact Leptin Receptor Is Selectively Expressed in Human Fetal Pituitary and Pituitary Adenomas and Signals Human Fetal Pituitary Growth Hormone Secretion.
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Inverse Correlation between Serum Testosterone and Leptin in Men.
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H. Snieder, A. J. MacGregor, and T. D. Spector (1998)
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