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Science 20 December 1996:
Vol. 274. no. 5295, pp. 2082 - 2086
DOI: 10.1126/science.274.5295.2082
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Reports

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

Alexander Pfeifer, * Attila Aszódi, dagger Ursula Seidler, dagger Peter Ruth, Franz Hofmann, Reinhard Fässler

Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.

A. Pfeifer, P. Ruth, F. Hofmann, Institut für Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Strasse 29, D-80802 München, Germany.
A. Aszódi and R. Fässler, Max-Planck-Institut für Biochemie, D-82152 Martinsried, Germany.
U. Seidler, Medizinische Klinik I, Eberhard-Karls-Universität Tübingen, D-72076 Tübingen, Germany.
*   To whom correspondence should be addressed. E-mail: pfeifer{at}ipt.med.tu-muenchen.de

dagger    These authors contributed equally to the work.

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Activation of Protein Kinase C Stimulates the Dephosphorylation of Natriuretic Peptide Receptor-B at a Single Serine Residue. A POSSIBLE MECHANISM OF HETEROLOGOUS DESENSITIZATION.
L. R. Potter and T. Hunter (2000)
J. Biol. Chem. 275, 31099-31106
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Molecular Determinants of the Interaction between the Inositol 1,4,5-Trisphosphate Receptor-associated cGMP Kinase Substrate (IRAG) and cGMP Kinase Ibeta.
A. Ammendola, A. Geiselhoringer, F. Hofmann, and J. Schlossmann (2001)
J. Biol. Chem. 276, 24153-24159
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Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
P. Hedlund, A. Aszodi, A. Pfeifer, P. Alm, F. Hofmann, M. Ahmad, R. Fassler, and K.-E. Andersson (2000)
PNAS 97, 2349-2354
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Dwarfism and early death in mice lacking C-type natriuretic peptide.
H. Chusho, N. Tamura, Y. Ogawa, A. Yasoda, M. Suda, T. Miyazawa, K. Nakamura, K. Nakao, T. Kurihara, Y. Komatsu, et al. (2001)
PNAS 98, 4016-4021
   Abstract »    Full Text »    PDF »
cGMP-Dependent Protein Kinase I Mediates the Negative Inotropic Effect of cGMP in the Murine Myocardium.
J. W. Wegener, H. Nawrath, W. Wolfsgruber, S. Kuhbandner, C. Werner, F. Hofmann, and R. Feil (2002)
Circ. Res. 90, 18-20
   Abstract »    Full Text »    PDF »


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