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Science 20 December 1996:
Vol. 274. no. 5295, pp. 2057 - 2059
DOI: 10.1126/science.274.5295.2057
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Reports

Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas

Guoren Deng, You Lu, Galina Zlotnikov, Ann D. Thor, Helene S. Smith *

Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent aberration was at chromosome 3p22-25; of ten cases with this LOH in the carcinoma, six displayed the same LOH in adjacent normal lobules. This suggests that in a subset of sporadic breast cancers, a tumor suppresser gene at 3p22-25 may be important in initiation or early progression of tumorigenesis. Among sixteen breast cancers with LOH at 17p13.1 and five breast cancers with LOH at 11p15.5, one case each displayed the same LOH in adjacent normal lobules. Thus the molecular heterogeneity that characterizes invasive breast cancers may occur at the earliest detectable stages of progression.

G. Deng, Y. Lu, G. Zlotnikov, Geraldine Brush Cancer Research Institute, California Pacific Medical Center, 2330 Clay Street, San Francisco, CA 94619, USA.
A. D. Thor, Department of Pathology, Northwestern University School of Medicine, Evanston Hospital, 2650 Ridge Avenue, Evanston, IL 60201, USA.
H. S. Smith, Geraldine Brush Cancer Research Institute, California Pacific Medical Center, 2330 Clay Street, San Francisco, CA 94619, and Department of Medicine, University of California, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed.

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