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Science 13 December 1996:
Vol. 274. no. 5294, pp. 1906 - 1909
DOI: 10.1126/science.274.5294.1906
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Reports

CD5-Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B Cells

Gabriel Bikah, Jacqueline Carey, John R. Ciallella, Alexander Tarakhovsky, Subbarao Bondada *

A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo apoptosis. However, in CD5-deficient mice, B-1 cells responded to mIgM crosslinking by developing a resistance to apoptosis and entering the cell cycle. In wild-type B-1 cells, prevention of association between CD5 and mIgM rescued their growth response to mIgM crosslinking. Thus the B cell receptor-mediated signaling is negatively regulated by CD5 in normal B-1 cells.

G. Bikah, J. Carey, J. R. Ciallella, S. Bondada, Department of Microbiology and Immunology and Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
A. Tarakhovsky, Institute for Genetics, University of Cologne, 50937 Cologne, Germany.
*   To whom correspondence should be addressed. E-mail: sbonda{at}pop.uky.edu

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   Abstract »    Full Text »    PDF »
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J. Calvo, J. M. Vilda, L. Places, M. Simarro, O. Padilla, D. Andreu, K. S. Campbell, C. Aussel, and F. Lozano (1998)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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R. Koskinen, T. W. F. Gobel, C. A. Tregaskes, J. R. Young, and O. Vainio (1998)
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S. Muthukkumar, S.-S. Han, S. Muthukkumar, V. M. Rangnekar, and S. Bondada (1997)
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J. Exp. Med. 185, 981-984
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