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Science 13 December 1996:
Vol. 274. no. 5294, pp. 1906 - 1909
DOI: 10.1126/science.274.5294.1906
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Reports

CD5-Mediated Negative Regulation of Antigen Receptor-Induced Growth Signals in B-1 B Cells

Gabriel Bikah, Jacqueline Carey, John R. Ciallella, Alexander Tarakhovsky, Subbarao Bondada *

A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo apoptosis. However, in CD5-deficient mice, B-1 cells responded to mIgM crosslinking by developing a resistance to apoptosis and entering the cell cycle. In wild-type B-1 cells, prevention of association between CD5 and mIgM rescued their growth response to mIgM crosslinking. Thus the B cell receptor-mediated signaling is negatively regulated by CD5 in normal B-1 cells.

G. Bikah, J. Carey, J. R. Ciallella, S. Bondada, Department of Microbiology and Immunology and Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
A. Tarakhovsky, Institute for Genetics, University of Cologne, 50937 Cologne, Germany.
*   To whom correspondence should be addressed. E-mail: sbonda{at}pop.uky.edu

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   Abstract »    Full Text »    PDF »
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