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Science 6 December 1996:
Vol. 274. no. 5293, pp. 1732 - 1736
DOI: 10.1126/science.274.5293.1732
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Reports

DPY-26, a Link Between Dosage Compensation and Meiotic Chromosome Segregation in the Nematode

Jason D. Lieb, Elizabeth E. Capowski, Philip Meneely, * Barbara J. Meyer dagger

The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).

J. D. Lieb and B. J. Meyer, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
E. E. Capowski and P. Meneely, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
*   Present address: Department of Biology, Haverford College, Haverford, PA 19041, USA.

dagger    To whom correspondence should be addressed.

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