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This article has been retracted

Science 6 December 1996:
Vol. 274. no. 5293, pp. 1729 - 1732
DOI: 10.1126/science.274.5293.1729
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Reports

Survival of Cholinergic Forebrain Neurons in Developing p75NGFR-Deficient Mice

Catharina E. E. M. Van der Zee, Gregory M. Ross, Richard J. Riopelle, Theo Hagg *

The functions of the low-affinity p75 nerve growth factor receptor (p75NGFR) in the central nervous system were explored in vivo. In normal mice, approximately 25 percent of the cholinergic basal forebrain neurons did not express TrkA and died between postnatal day 6 and 15. This loss did not occur in p75NGFR-deficient mice or in normal mice systemically injected with a p75NGFR-inhibiting peptide. Control, but not p75NGFR-deficient, mice also had fewer cholinergic striatal interneurons. Apparently, p75NGFR mediates apoptosis of these developing neurons in the absence of TrkA, and modulation of p75NGFR can promote neuronal survival. Cholinergic basal forebrain neurons are involved in learning and memory.

C. E. E. M. Van der Zee and T. Hagg, Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada.
G. M. Ross and R. J. Riopelle, Department of Medicine (Neurology), Queen's University, Kingston, Ontario K7L 2V7, Canada.
*   To whom correspondence should be addressed. E-mail: thagg{at}is.dal.ca

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