Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 December 1996:
Vol. 274. no. 5293, pp. 1672 - 1677
DOI: 10.1126/science.274.5293.1672
Prev | Table of Contents | Next

Articles

Cancer Cell Cycles

Charles J. Sherr

Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16INK4a and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life.

The author is at the Howard Hughes Medical Institute, Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA. E-mail: sherr{at}stjude.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Docosahexaenoic acid reduces suppressive and migratory functions of CD4CD25 regulatory T-cells.
A. Yessoufou, A. Ple, K. Moutairou, A. Hichami, and N. A. Khan (2009)
J. Lipid Res. 50, 2377-2388
   Abstract »    Full Text »    PDF »
Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation.
S. Wang and Y. Li (2009)
Am J Physiol Heart Circ Physiol 297, H2075-H2083
   Abstract »    Full Text »    PDF »
Evaluation of an ELISA for p16INK4a as a Screening Test for Cervical Cancer.
A. Balasubramanian, J. Hughes, C. Mao, R. Ridder, M. Herkert, N. B. Kiviat, and L. A. Koutsky (2009)
Cancer Epidemiol. Biomarkers Prev. 18, 3008-3017
   Abstract »    Full Text »    PDF »
High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapy.
D. Trere, E. Brighenti, G. Donati, C. Ceccarelli, D. Santini, M. Taffurelli, L. Montanaro, and M. Derenzini (2009)
Ann. Onc. 20, 1818-1823
   Abstract »    Full Text »    PDF »
Safety, tolerability, pharmacokinetics and pharmacodynamics of the oral cyclin-dependent kinase inhibitor AZD5438 when administered at intermittent and continuous dosing schedules in patients with advanced solid tumours.
D. S. Boss, G. K. Schwartz, M. R. Middleton, D. D. Amakye, H. Swaisland, R. S. Midgley, M. Ranson, S. Danson, H. Calvert, R. Plummer, et al. (2009)
Ann. Onc.
   Abstract »    Full Text »    PDF »
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
E. Iorns, S. R. Martens-de Kemp, C. J. Lord, and A. Ashworth (2009)
Carcinogenesis 30, 1696-1701
   Abstract »    Full Text »    PDF »
Alpinia pricei Rhizome Extracts Induce Cell Cycle Arrest in Human Squamous Carcinoma KB Cells and Suppress Tumor Growth in Nude Mice.
Y.-C. Hseu, C.-S. Chen, and S.-Y. Wang (2009)
Evid. Based Complement. Altern. Med.
   Abstract »    Full Text »    PDF »
Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.
D. W. Meechan, E. S. Tucker, T. M. Maynard, and A.-S. LaMantia (2009)
PNAS 106, 16434-16445
   Abstract »    Full Text »    PDF »
Low p27 Expression Predicts Early Relapse and Death in Postmenopausal Hormone Receptor-Positive Breast Cancer Patients Receiving Adjuvant Tamoxifen Therapy.
M. Filipits, M. Rudas, H. Heinzl, R. Jakesz, E. Kubista, S. Lax, W. Schippinger, O. Dietze, R. Greil, W. Stiglbauer, et al. (2009)
Clin. Cancer Res. 15, 5888-5894
   Abstract »    Full Text »    PDF »
Breast Cancer and Cyclin D1 Gene Polymorphism in Turkish Women.
I. YAYLIM-ERALTAN, A. ERGEN, U. GORMUS, S. ARIKAN, S. KUCUCUK, O. SAHIN, N. YIGIT, Y. YILDIZ, and T. ISBIR (2009)
In Vivo 23, 767-772
   Abstract »    Full Text »    PDF »
The role of AUF1 in thyroid carcinoma progression.
B. Trojanowicz, L. Brodauf, C. Sekulla, K. Lorenz, R. Finke, H. Dralle, and C. Hoang-Vu (2009)
Endocr. Relat. Cancer 16, 857-871
   Abstract »    Full Text »    PDF »
Preclinical biomarkers for a cyclin-dependent kinase inhibitor translate to candidate pharmacodynamic biomarkers in phase I patients.
W. Berkofsky-Fessler, T. Q. Nguyen, P. Delmar, J. Molnos, C. Kanwal, W. DePinto, J. Rosinski, P. McLoughlin, S. Ritland, M. DeMario, et al. (2009)
Mol. Cancer Ther. 8, 2517-2525
   Abstract »    Full Text »    PDF »
Targeted Radiotherapy for Prostate Cancer with an Oncolytic Adenovirus Coding for Human Sodium Iodide Symporter.
T. Hakkarainen, M. Rajecki, M. Sarparanta, M. Tenhunen, A. J. Airaksinen, R. A. Desmond, K. Kairemo, and A. Hemminki (2009)
Clin. Cancer Res. 15, 5396-5403
   Abstract »    Full Text »    PDF »
Pivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid.
V. Llado, S. Teres, M. Higuera, R. Alvarez, M. A. Noguera-Salva, J. E. Halver, P. V. Escriba, and X. Busquets (2009)
PNAS 106, 13754-13758
   Abstract »    Full Text »    PDF »
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.
J. J. Molenaar, M. E. Ebus, D. Geerts, J. Koster, F. Lamers, L. J. Valentijn, E. M. Westerhout, R. Versteeg, and H. N. Caron (2009)
PNAS 106, 12968-12973
   Abstract »    Full Text »    PDF »
Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation.
L. Bockstaele, X. Bisteau, S. Paternot, and P. P. Roger (2009)
Mol. Cell. Biol. 29, 4188-4200
   Abstract »    Full Text »    PDF »
The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity.
S. Ali, D. A. Heathcote, S. H.B. Kroll, A. S. Jogalekar, B. Scheiper, H. Patel, J. Brackow, A. Siwicka, M. J. Fuchter, M. Periyasamy, et al. (2009)
Cancer Res. 69, 6208-6215
   Abstract »    Full Text »    PDF »
Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft.
M. Kaur, B. Velmurugan, A. Tyagi, G. Deep, S. Katiyar, C. Agarwal, and R. Agarwal (2009)
Mol. Cancer Ther. 8, 2366-2374
   Abstract »    Full Text »    PDF »
Activation of Phosphatidylinositol-3'-kinase/AKT Signaling Is Essential in Hepatoblastoma Survival.
W. Hartmann, J. Kuchler, A. Koch, N. Friedrichs, A. Waha, E. Endl, J. Czerwitzki, D. Metzger, S. Steiner, P. Wurst, et al. (2009)
Clin. Cancer Res. 15, 4538-4545
   Abstract »    Full Text »    PDF »
Recurrent intrathoracic thymomas: Potential prognostic importance of cell-cycle protein expression.
T. C. Mineo, V. Ambrogi, A. Baldi, E. Pompeo, and D. Mineo (2009)
J. Thorac. Cardiovasc. Surg. 138, 40-45
   Abstract »    Full Text »    PDF »
Inhibition of G1 to S Phase Progression by a Novel Zinc Finger Protein P58TFL at P-bodies.
K. Minagawa, Y. Katayama, S. Nishikawa, K. Yamamoto, A. Sada, A. Okamura, M. Shimoyama, and T. Matsui (2009)
Mol. Cancer Res. 7, 880-889
   Abstract »    Full Text »    PDF »
PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation.
M. Zhang, R. Xie, W. Hou, B. Wang, R. Shen, X. Wang, Q. Wang, T. Zhu, J. H. Jonason, and D. Chen (2009)
J. Cell Sci. 122, 1382-1389
   Abstract »    Full Text »    PDF »
Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells.
Q.-Q. Li, J.-D. Xu, W.-J. Wang, X.-X. Cao, Q. Chen, F. Tang, Z.-Q. Chen, X.-P. Liu, and Z.-D. Xu (2009)
Clin. Cancer Res. 15, 2657-2665
   Abstract »    Full Text »    PDF »
ZD1839 (IRESSA(R)) Stabilizes p27Kip1 and Enhances Radiosensitivity in Cholangiocarcinoma Cell Lines.
S. YABUUCHI, Y. KATAYOSE, A. ODA, M. MIZUMA, S. SHIRASOU, T. SASAKI, K. YAMAMOTO, M. OIKAWA, T. RIKIYAMA, T. ONOGAWA, et al. (2009)
Anticancer Res 29, 1169-1180
   Abstract »    Full Text »    PDF »
Immunohistochemical Evaluation of Vascular Urinary Bladder Tumors from Cows with Enzootic Hematuria.
T. Carvalho, D. Naydan, T. Nunes, C. Pinto, and M. C. Peleteiro (2009)
Vet. Pathol. 46, 211-221
   Abstract »    Full Text »    PDF »
Identification of Potential Therapeutic Targets in Malignant Mesothelioma Using Cell-Cycle Gene Expression Analysis.
S. Romagnoli, E. Fasoli, V. Vaira, M. Falleni, C. Pellegrini, A. Catania, M. Roncalli, A. Marchetti, L. Santambrogio, G. Coggi, et al. (2009)
Am. J. Pathol. 174, 762-770
   Abstract »    Full Text »    PDF »
Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.
T. Mizoguchi, A. Muto, N. Udagawa, A. Arai, T. Yamashita, A. Hosoya, T. Ninomiya, H. Nakamura, Y. Yamamoto, S. Kinugawa, et al. (2009)
J. Cell Biol. 184, 541-554
   Abstract »    Full Text »    PDF »
The Combination of Low Cytoplasmic and High Nuclear Expression of p27 Predicts a Better Prognosis in High-grade Astrocytoma.
T. HIDAKA, S. HAMA, P. SHRESTHA, T. SAITO, Y. KAJIWARA, F. YAMASAKI, K. SUGIYAMA, and K. KURISU (2009)
Anticancer Res 29, 597-603
   Abstract »    Full Text »    PDF »
Dissociation of E-cadherin and {beta}-catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophy.
Y. Feng, X. Sun, H. Yang, and D. H. Teitelbaum (2009)
J. Physiol. 587, 641-654
   Abstract »    Full Text »    PDF »
Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.
M. S. Squires, R. E. Feltell, N. G. Wallis, E. J. Lewis, D.-M. Smith, D. M. Cross, J. F. Lyons, and N. T. Thompson (2009)
Mol. Cancer Ther. 8, 324-332
   Abstract »    Full Text »    PDF »
Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression.
J. A. Willoughby Sr., S. N. Sundar, M. Cheung, A. S. Tin, J. Modiano, and G. L. Firestone (2009)
J. Biol. Chem. 284, 2203-2213
   Abstract »    Full Text »    PDF »
E2F-like elements in p27Kip1 promoter specifically sense deregulated E2F activity.
E. Ozono, H. Komori, R. Iwanaga, M.-A. Ikeda, S. Iseki, and K. Ohtani (2009)
Genes Cells 14, 89-99
   Abstract »    Full Text »    PDF »
Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability.
L. L. Pontano, P. Aggarwal, O. Barbash, E. J. Brown, C. H. Bassing, and J. A. Diehl (2008)
Mol. Cell. Biol. 28, 7245-7258
   Abstract »    Full Text »    PDF »
Mechanical Strain Inhibits Adipogenesis in Mesenchymal Stem Cells by Stimulating a Durable {beta}-Catenin Signal.
B. Sen, Z. Xie, N. Case, M. Ma, C. Rubin, and J. Rubin (2008)
Endocrinology 149, 6065-6075
   Abstract »    Full Text »    PDF »
cAMP-mediated Induction of Cyclin E Sensitizes Growth-arrested Adipose Stem Cells to DNA Damage-induced Apoptosis.
H. Ugland, A. C. Boquest, S. Naderi, P. Collas, and H. K. Blomhoff (2008)
Mol. Biol. Cell 19, 5082-5092
   Abstract »    Full Text »    PDF »
Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines.
I. Cozar-Castellano, G. Harb, K. Selk, K. Takane, R. Vasavada, B. Sicari, B. Law, P. Zhang, D. K. Scott, N. Fiaschi-Taesch, et al. (2008)
Diabetes 57, 3056-3068
   Abstract »    Full Text »    PDF »
Functional Analysis of a Cell Cycle-Associated, Tumor-Suppressive Gene, Protein Tyrosine Phosphatase Receptor Type G, in Nasopharyngeal Carcinoma.
A. K. L. Cheung, H. L. Lung, S. C. Hung, E. W. L. Law, Y. Cheng, W. L. Yau, D. K. Bangarusamy, L. D. Miller, E. T.-B. Liu, J.-Y. Shao, et al. (2008)
Cancer Res. 68, 8137-8145
   Abstract »    Full Text »    PDF »
Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention.
D. Wu and S. N. Meydani (2008)
J. Leukoc. Biol. 84, 900-914
   Abstract »    Full Text »    PDF »
A Gender-Specific Retinoblastoma-Related Protein in Volvox carteri Implies a Role for the Retinoblastoma Protein Family in Sexual Development.
A. Kianianmomeni, G. Nematollahi, and A. Hallmann (2008)
PLANT CELL 20, 2399-2419
   Abstract »    Full Text »    PDF »
G2E3 Is a Dual Function Ubiquitin Ligase Required for Early Embryonic Development.
W. S. Brooks, E. S. Helton, S. Banerjee, M. Venable, L. Johnson, T. R. Schoeb, R. A. Kesterson, and D. F. Crawford (2008)
J. Biol. Chem. 283, 22304-22315
   Abstract »    Full Text »    PDF »
RNA Interference for Discoidin Domain Receptor 2 Attenuates Neointimal Formation in Balloon Injured Rat Carotid Artery.
K.-G. Shyu, B.-W. Wang, P. Kuan, and H. Chang (2008)
Arterioscler Thromb Vasc Biol 28, 1447-1453
   Abstract »    Full Text »    PDF »
Cyproheptadine displays preclinical activity in myeloma and leukemia.
X. Mao, S.-b. Liang, R. Hurren, M. Gronda, S. Chow, G. W. Xu, X. Wang, R. B. Zavareh, N. Jamal, H. Messner, et al. (2008)
Blood 112, 760-769
   Abstract »    Full Text »    PDF »
Noninvasive Assessment of E2F-1-Mediated Transcriptional Regulation In vivo.
P. Monfared, A. Winkeler, M. Klein, H. Li, A. Klose, M. Hoesel, Y. Waerzeggers, S. Korsching, and A. H. Jacobs (2008)
Cancer Res. 68, 5932-5940
   Abstract »    Full Text »    PDF »
Rb Depletion Results in Deregulation of E-Cadherin and Induction of Cellular Phenotypic Changes that Are Characteristic of the Epithelial-to-Mesenchymal Transition.
Y. Arima, Y. Inoue, T. Shibata, H. Hayashi, O. Nagano, H. Saya, and Y. Taya (2008)
Cancer Res. 68, 5104-5112
   Abstract »    Full Text »    PDF »
Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis.
K Assi, J Mills, D Owen, C Ong, R St Arnaud, S Dedhar, and B Salh (2008)
Gut 57, 931-940
   Abstract »    Full Text »    PDF »
Fhit-Deficient Hematopoietic Stem Cells Survive Hydroquinone Exposure Carrying Precancerous Changes.
H. Ishii, K. Mimori, K. Ishikawa, H. Okumura, F. Pichiorri, T. Druck, H. Inoue, A. Vecchione, T. Saito, M. Mori, et al. (2008)
Cancer Res. 68, 3662-3670
   Abstract »    Full Text »    PDF »
Evaluation of the In vitro and In vivo Antitumor Activity of Histone Deacetylase Inhibitors for the Therapy of Retinoblastoma.
C. L. Dalgard, K. R. Van Quill, and J. M. O'Brien (2008)
Clin. Cancer Res. 14, 3113-3123
   Abstract »    Full Text »    PDF »
Proliferating Active Cells, Lymphocyte Subsets, and Dendritic Cells in Recurrent Tonsillitis: Their Effect on Hypertrophy.
N. Alatas and F. Baba (2008)
Arch Otolaryngol Head Neck Surg 134, 477-483
   Abstract »    Full Text »    PDF »
A phase I/II study of bortezomib and capecitabine in patients with metastatic breast cancer previously treated with taxanes and/or anthracyclines.
P. Schmid, D. Kuhnhardt, P. Kiewe, S. Lehenbauer-Dehm, W. Schippinger, R. Greil, W. Lange, J. Preiss, N. Niederle, P. Brossart, et al. (2008)
Ann. Onc. 19, 871-876
   Abstract »    Full Text »    PDF »
Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma.
J. J. Molenaar, M. E. Ebus, J. Koster, P. v. Sluis, C. J.M. van Noesel, R. Versteeg, and H. N. Caron (2008)
Cancer Res. 68, 2599-2609
   Abstract »    Full Text »    PDF »
Loss of Retinoblastoma Tumor Suppressor Protein Makes Human Breast Cancer Cells More Sensitive to Antimetabolite Exposure.
M. Derenzini, G. Donati, G. Mazzini, L. Montanaro, M. Vici, C. Ceccarelli, D. Santini, M. Taffurelli, and D. Trere (2008)
Clin. Cancer Res. 14, 2199-2209
   Abstract »    Full Text »    PDF »
Genetic Polymorphisms and Head and Neck Cancer Outcomes: A Review.
J. Hopkins, D. W. Cescon, D. Tse, P. Bradbury, W. Xu, C. Ma, P. Wheatley-Price, J. Waldron, D. Goldstein, F. Meyer, et al. (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 490-499
   Abstract »    Full Text »    PDF »
Immune Expression and Inhibition of Heat Shock Protein 90 in Uveal Melanoma.
D. Faingold, J.-C. Marshall, E. Antecka, S. Di Cesare, A. N. Odashiro, S. Bakalian, B. F. Fernandes, and M. N. Burnier Jr. (2008)
Clin. Cancer Res. 14, 847-855
   Abstract »    Full Text »    PDF »
Inhibition of Cell Cycle Progression by Hydroxytyrosol Is Associated with Upregulation of Cyclin-Dependent Protein Kinase Inhibitors p21WAF1/Cip1 and p27Kip1 and with Induction of Differentiation in HL60 Cells.
R. Fabiani, P. Rosignoli, A. De Bartolomeo, R. Fuccelli, and G. Morozzi (2008)
J. Nutr. 138, 42-48
   Abstract »    Full Text »    PDF »
Computational Analysis of Mammalian Cell Division Gated by a Circadian Clock: Quantized Cell Cycles and Cell Size Control.
J. Zamborszky, C. I. Hong, and A. Csikasz Nagy (2007)
J Biol Rhythms 22, 542-553
   Abstract »    PDF »
Decursin Suppresses Human Androgen-Independent PC3 Prostate Cancer Cell Proliferation by Promoting the Degradation of beta-Catenin.
G.-Y. Song, J.-H. Lee, M. Cho, B.-S. Park, D.-E. Kim, and S. Oh (2007)
Mol. Pharmacol. 72, 1599-1606
   Abstract »    Full Text »    PDF »
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication.
P. Aggarwal, M. D. Lessie, D. I. Lin, L. Pontano, A. B. Gladden, B. Nuskey, A. Goradia, M. A. Wasik, A. J.P. Klein-Szanto, A. K. Rustgi, et al. (2007)
Genes & Dev. 21, 2908-2922
   Abstract »    Full Text »    PDF »
Morphologically Normal-Appearing Mammary Epithelial Cells Obtained from High-Risk Women Exhibit Methylation Silencing of INK4a/ARF.
G. R. Bean, A. D. Bryson, P. G. Pilie, V. Goldenberg, J. C. Baker Jr., C. Ibarra, D. M.U. Brander, C. Paisie, N. R. Case, M. Gauthier, et al. (2007)
Clin. Cancer Res. 13, 6834-6841
   Abstract »    Full Text »    PDF »
p300 expression repression by hypermethylation associated with tumour invasion and metastasis in oesophageal squamous cell carcinoma.
C. Zhang, K. Li, L. Wei, Z. Li, P. Yu, L. Teng, K. Wu, and J. Zhu (2007)
J. Clin. Pathol. 60, 1249-1253
   Abstract »    Full Text »    PDF »
Loss of p27Kip1 enhances tumor progression in chronic hepatocyte injury-induced liver tumorigenesis with widely ranging effects on Cdk2 or Cdc2 activation.
D. Sun, H. Ren, M. Oertel, R. S. Sellers, and L. Zhu (2007)
Carcinogenesis 28, 1859-1866
   Abstract »    Full Text »    PDF »
Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells.
L. Hong, Y. Zhao, Y. Han, W. Guo, H. Jin, T. Qiao, Z. Che, and D. Fan (2007)
Carcinogenesis 28, 1622-1628
   Abstract »    Full Text »    PDF »
ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells.
H. Kikuchi, C. Uchida, T. Hattori, T. Isobe, Y. Hiramatsu, K. Kitagawa, T. Oda, H. Konno, and M. Kitagawa (2007)
Carcinogenesis 28, 1752-1758
   Abstract »    Full Text »    PDF »
SWI/SNF Activity Is Required for the Repression of Deoxyribonucleotide Triphosphate Metabolic Enzymes via the Recruitment of mSin3B.
R. W. Gunawardena, S. R. Fox, H. Siddiqui, and E. S. Knudsen (2007)
J. Biol. Chem. 282, 20116-20123
   Abstract »    Full Text »    PDF »
Cell Cycle Regulators and Outcome of Adjuvant Cisplatin-Based Chemotherapy in Completely Resected Non-Small-Cell Lung Cancer: The International Adjuvant Lung Cancer Trial Biologic Program.
M. Filipits, R. Pirker, A. Dunant, S. Lantuejoul, K. Schmid, A. Huynh, V. Haddad, F. Andre, R. Stahel, J.-P. Pignon, et al. (2007)
J. Clin. Oncol. 25, 2735-2740
   Abstract »    Full Text »    PDF »
An Epigenetically Derived Monoclonal Origin for Recurrent Respiratory Papillomatosis.
J. K. Stephen, L. E. Vaught, K. M. Chen, V. Shah, V. G. Schweitzer, G. Gardner, M. S. Benninger, and M. J. Worsham (2007)
Arch Otolaryngol Head Neck Surg 133, 684-692
   Abstract »    Full Text »    PDF »
Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo.
F. Lian, D. E. Smith, H. Ernst, R. M. Russell, and X.-D. Wang (2007)
Carcinogenesis 28, 1567-1574
   Abstract »    Full Text »    PDF »
MMP-9 Short Interfering RNA Induced Senescence Resulting in Inhibition of Medulloblastoma Growth via p16INK4a and Mitogen-Activated Protein Kinase Pathway.
J. S. Rao, P. Bhoopathi, C. Chetty, M. Gujrati, and S. S. Lakka (2007)
Cancer Res. 67, 4956-4964
   Abstract »    Full Text »    PDF »
Aurora-A and p16 Polymorphisms Contribute to an Earlier Age at Diagnosis of Pancreatic Cancer in Caucasians.
J. Chen, D. Li, C. Wei, S. Sen, A. M. Killary, C. I. Amos, D. B. Evans, J. L. Abbruzzese, and M. L. Frazier (2007)
Clin. Cancer Res. 13, 3100-3104
   Abstract »    Full Text »    PDF »
Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression.
E. Nurtjahja-Tjendraputra, D. Fu, J. M. Phang, and D. R. Richardson (2007)
Blood 109, 4045-4054
   Abstract »    Full Text »    PDF »
Tumor-Specific Cooperation of Retinoblastoma Protein Family and Snf5 Inactivation.
J. Chai, X. Lu, V. Godfrey, C. Fletcher, C. W.M. Roberts, T. Van Dyke, and B. E. Weissman (2007)
Cancer Res. 67, 3002-3009
   Abstract »    Full Text »    PDF »
SMAR1-derived P44 Peptide Retains Its Tumor Suppressor Function through Modulation of p53.
A. Jalota-Badhwar, R. Kaul-Ghanekar, D. Mogare, R. Boppana, K. M. Paknikar, and S. Chattopadhyay (2007)
J. Biol. Chem. 282, 9902-9913
   Abstract »    Full Text »    PDF »
Involvement of IFN Regulatory Factor (IRF)-1 and IRF-2 in the Formation and Progression of Human Esophageal Cancers.
Y. Wang, D.-P. Liu, P.-P. Chen, H. P. Koeffler, X.-J. Tong, and D. Xie (2007)
Cancer Res. 67, 2535-2543
   Abstract »    Full Text »    PDF »
Selective Requirements for E2f3 in the Development and Tumorigenicity of Rb-Deficient Chimeric Tissues.
T. Parisi, T. L. Yuan, A. M. Faust, A. M. Caron, R. Bronson, and J. A. Lees (2007)
Mol. Cell. Biol. 27, 2283-2293
   Abstract »    Full Text »    PDF »
Epistatic Relationship between the Cancer Susceptibility Genes CHEK2 and p27.
C. Cybulski, B. Gliniewicz, A. Sikorski, J. Kladny, T. Huzarski, J. Gronwald, T. Byrski, T. Debniak, B. Gorski, A. Jakubowska, et al. (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 572-576
   Abstract »    Full Text »    PDF »
P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.
K. S. Joshi, M. J. Rathos, P. Mahajan, V. Wagh, S. Shenoy, D. Bhatia, S. Chile, M. Sivakumar, A. Maier, H.-H. Fiebig, et al. (2007)
Mol. Cancer Ther. 6, 926-934
   Abstract »    Full Text »    PDF »
p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors.
F. Bai, X.-H. Pei, T. Nishikawa, M. D. Smith, and Y. Xiong (2007)
Mol. Cell. Biol. 27, 1495-1504
   Abstract »    Full Text »    PDF »
Cdk phosphorylation of the Ste11 transcription factor constrains differentiation-specific transcription to G1.
S. Kjaerulff, N. R. Andersen, M. T. Borup, and O. Nielsen (2007)
Genes & Dev. 21, 347-359
   Abstract »    Full Text »    PDF »
Treatment of prostate cancer with Ad5/3{Delta}24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo.
M. Rajecki, A. Kanerva, U.-H. Stenman, M. Tenhunen, L. Kangasniemi, M. Sarkioja, M. Y. Ala-Opas, H. Alfthan, A. Sankila, E. Rintala, et al. (2007)
Mol. Cancer Ther. 6, 742-751
   Abstract »    Full Text »    PDF »
Hyaluronan-CD44 Interaction with Neural Wiskott-Aldrich Syndrome Protein (N-WASP) Promotes Actin Polymerization and ErbB2 Activation Leading to beta-Catenin Nuclear Translocation, Transcriptional Up-regulation, and Cell Migration in Ovarian Tumor Cells.
L. Y. W. Bourguignon, K. Peyrollier, E. Gilad, and A. Brightman (2007)
J. Biol. Chem. 282, 1265-1280
   Abstract »    Full Text »    PDF »
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene.
Y. Kotake, R. Cao, P. Viatour, J. Sage, Y. Zhang, and Y. Xiong (2007)
Genes & Dev. 21, 49-54
   Abstract »    Full Text »    PDF »
Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.
D. Y. Lim, Y. Jeong, A. L. Tyner, and J. H. Y. Park (2007)
Am J Physiol Gastrointest Liver Physiol 292, G66-G75
   Abstract »    Full Text »    PDF »
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest.
S. Sarfaraz, F. Afaq, V. M. Adhami, A. Malik, and H. Mukhtar (2006)
J. Biol. Chem. 281, 39480-39491
   Abstract »    Full Text »    PDF »
Evidence for CDK-Dependent and CDK-Independent Functions of the Murine Gammaherpesvirus 68 v-Cyclin.
J. W. Upton and S. H. Speck (2006)
J. Virol. 80, 11946-11959
   Abstract »    Full Text »    PDF »
Involvement of GSK-3beta and DYRK1B in Differentiation-inducing Factor-3-induced Phosphorylation of Cyclin D1 in HeLa Cells.
F. Takahashi-Yanaga, J. Mori, E. Matsuzaki, Y. Watanabe, M. Hirata, Y. Miwa, S. Morimoto, and T. Sasaguri (2006)
J. Biol. Chem. 281, 38489-38497
   Abstract »    Full Text »    PDF »
The effect of the cyclin D1 (CCND1) A870G polymorphism on colorectal cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health Study.
N. M. Probst-Hensch, C.-L. Sun, D. V. D. Berg, M. Ceschi, W.-P. Koh, and M. C. Yu (2006)
Carcinogenesis 27, 2475-2482
   Abstract »    Full Text »    PDF »
GATHER: a systems approach to interpreting genomic signatures.
J. T. Chang and J. R. Nevins (2006)
Bioinformatics 22, 2926-2933
   Abstract »    Full Text »    PDF »
Reprimo Methylation Is a Potential Biomarker of Barrett's-Associated Esophageal Neoplastic Progression..
J. P. Hamilton, F. Sato, Z. Jin, B. D. Greenwald, T. Ito, Y. Mori, B. C. Paun, T. Kan, Y. Cheng, S. Wang, et al. (2006)
Clin. Cancer Res. 12, 6637-6642
   Abstract »    Full Text »    PDF »
Tumorigenic Conversion of Primary Human Esophageal Epithelial Cells Using Oncogene Combinations in the Absence of Exogenous Ras.
S.-H. Kim, H. Nakagawa, A. Navaraj, Y. Naomoto, A. J.P. Klein-Szanto, A. K. Rustgi, and W. S. El-Deiry (2006)
Cancer Res. 66, 10415-10424
   Abstract »    Full Text »    PDF »
Stromal and Epithelial Caveolin-1 Both Confer a Protective Effect Against Mammary Hyperplasia and Tumorigenesis: Caveolin-1 Antagonizes Cyclin D1 Function in Mammary Epithelial Cells.
T. M. Williams, F. Sotgia, H. Lee, G. Hassan, D. Di Vizio, G. Bonuccelli, F. Capozza, I. Mercier, H. Rui, R. G. Pestell, et al. (2006)
Am. J. Pathol. 169, 1784-1801
   Abstract »    Full Text »    PDF »
In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials..
W. DePinto, X.-J. Chu, X. Yin, M. Smith, K. Packman, P. Goelzer, A. Lovey, Y. Chen, H. Qian, R. Hamid, et al. (2006)
Mol. Cancer Ther. 5, 2644-2658
   Abstract »    Full Text »    PDF »
RUNX3 Inhibits the Expression of Vascular Endothelial Growth Factor and Reduces the Angiogenesis, Growth, and Metastasis of Human Gastric Cancer..
Z. Peng, D. Wei, L. Wang, H. Tang, J. Zhang, X. Le, Z. Jia, Q. Li, and K. Xie (2006)
Clin. Cancer Res. 12, 6386-6394
   Abstract »    Full Text »    PDF »
E2F1 Modulates p38 MAPK Phosphorylation via Transcriptional Regulation of ASK1 and Wip1.
T. Hershko, K. Korotayev, S. Polager, and D. Ginsberg (2006)
J. Biol. Chem. 281, 31309-31316
   Abstract »    Full Text »    PDF »
Up-regulation of Cyclin D1 by HBx Is Mediated by NF-{kappa}B2/BCL3 Complex through {kappa}B Site of Cyclin D1 Promoter.
S. G. Park, C. Chung, H. Kang, J.-Y. Kim, and G. Jung (2006)
J. Biol. Chem. 281, 31770-31777
   Abstract »    Full Text »    PDF »
A Gradient of Epidermal Growth Factor Receptor Signaling Determines the Sensitivity of rbf1 Mutant Cells to E2F-Dependent Apoptosis.
N.-S. Moon, L. Di Stefano, and N. Dyson (2006)
Mol. Cell. Biol. 26, 7601-7615
   Abstract »    Full Text »    PDF »
Common Variants in RB1 Gene and Risk of Invasive Ovarian Cancer..
H. Song, S. J. Ramus, D. Shadforth, L. Quaye, S. K. Kjaer, R. A. DiCioccio, A. M. Dunning, E. Hogdall, C. Hogdall, A. S. Whittemore, et al. (2006)
Cancer Res. 66, 10220-10226
   Abstract »    Full Text »    PDF »
Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation.
N. A. Khan, K. Nishimura, V. Aires, T. Yamashita, D. Oaxaca-Castillo, K. Kashiwagi, and K. Igarashi (2006)
J. Lipid Res. 47, 2306-2313
   Abstract »    Full Text »    PDF »
Cyclin D1 gene polymorphism as a risk factor for oral premalignant lesions.
M. Huang, M. R. Spitz, J. Gu, J.J. Lee, J. Lin, S. M.Lippman, and X. Wu (2006)
Carcinogenesis 27, 2034-2037
   Abstract »    Full Text »    PDF »
Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RAR{alpha}.
J.-g. Wang, L. W. Barsky, E. Davicioni, K. I. Weinberg, T. J. Triche, X.-k. Zhang, and L. Wu (2006)
FASEB J 20, 2142-2144
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)