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Science 6 December 1996:
Vol. 274. no. 5293, pp. 1664 - 1672
DOI: 10.1126/science.274.5293.1664
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Articles

Cell Cycle Checkpoints: Preventing an Identity Crisis

Stephen J. Elledge

Cell cycle checkpoints are regulatory pathways that control the order and timing of cell cycle transitions and ensure that critical events such as DNA replication and chromosome segregation are completed with high fidelity. In addition, checkpoints respond to damage by arresting the cell cycle to provide time for repair and by inducing transcription of genes that facilitate repair. Checkpoint loss results in genomic instability and has been implicated in the evolution of normal cells into cancer cells. Recent advances have revealed signal transduction pathways that transmit checkpoint signals in response to DNA damage, replication blocks, and spindle damage. Checkpoint pathways have components shared among all eukaryotes, underscoring the conservation of cell cycle regulatory machinery.

The author is in the Department of Biochemistry, Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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Mol. Endocrinol. 17, 2053-2069
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The Fission Yeast Rad32 (Mre11)-Rad50-Nbs1 Complex Is Required for the S-Phase DNA Damage Checkpoint.
C. Chahwan, T. M. Nakamura, S. Sivakumar, P. Russell, and N. Rhind (2003)
Mol. Cell. Biol. 23, 6564-6573
   Abstract »    Full Text »    PDF »
Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole, and Echinocandin Antifungal Agents in Saccharomyces cerevisiae.
A. K. Agarwal, P. D. Rogers, S. R. Baerson, M. R. Jacob, K. S. Barker, J. D. Cleary, L. A. Walker, D. G. Nagle, and A. M. Clark (2003)
J. Biol. Chem. 278, 34998-35015
   Abstract »    Full Text »    PDF »
Yaf9, a Novel NuA4 Histone Acetyltransferase Subunit, Is Required for the Cellular Response to Spindle Stress in Yeast.
I. Le Masson, D. Y. Yu, K. Jensen, A. Chevalier, R. Courbeyrette, Y. Boulard, M. M. Smith, and C. Mann (2003)
Mol. Cell. Biol. 23, 6086-6102
   Abstract »    Full Text »    PDF »
Association between Mitotic Spindle Checkpoint Impairment and Susceptibility to the Induction of Apoptosis by Anti-Microtubule Agents in Human Lung Cancers.
A. Masuda, K. Maeno, T. Nakagawa, H. Saito, and T. Takahashi (2003)
Am. J. Pathol. 163, 1109-1116
   Abstract »    Full Text »    PDF »
Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe.
S. Harris, C. Kemplen, T. Caspari, C. Chan, H. D. Lindsay, M. Poitelea, A. M. Carr, and C. Price (2003)
J. Cell Sci. 116, 3519-3529
   Abstract »    Full Text »    PDF »
XRad17 Is Required for the Activation of XChk1 But Not XCds1 during Checkpoint Signaling in Xenopus.
R. E. Jones, J. R. Chapman, C. Puligilla, J. M. Murray, A. M. Car, C. C. Ford, and H. D. Lindsay (2003)
Mol. Biol. Cell 14, 3898-3910
   Abstract »    Full Text »    PDF »
Regulatory Interactions between the Checkpoint Kinase Chk1 and the Proteins of the DNA-dependent Protein Kinase Complex.
D. M. Goudelock, K. Jiang, E. Pereira, B. Russell, and Y. Sanchez (2003)
J. Biol. Chem. 278, 29940-29947
   Abstract »    Full Text »    PDF »
The Relationship between Twenty Missense ATM Variants and Breast Cancer Risk: The Multiethnic Cohort.
P. Bretsky, C. A. Haiman, S. Gilad, J. Yahalom, A. Grossman, S. Paglin, D. Van Den Berg, L. N. Kolonel, R. Skaliter, and B. E. Henderson (2003)
Cancer Epidemiol. Biomarkers Prev. 12, 733-738
   Abstract »    Full Text »    PDF »
G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1.
M. Costanzo, O. Schub, and B. Andrews (2003)
Mol. Cell. Biol. 23, 5064-5077
   Abstract »    Full Text »    PDF »
Schizosaccharomyces pombe Checkpoint Response to DNA Interstrand Cross-Links.
S. Lambert, S. J. Mason, L. J. Barber, J. A. Hartley, J. A. Pearce, A. M. Carr, and P. J. McHugh (2003)
Mol. Cell. Biol. 23, 4728-4737
   Abstract »    Full Text »    PDF »
Distinct Functions of Nijmegen Breakage Syndrome in Ataxia Telangiectasia Mutated-Dependent Responses to DNA Damage.
J. H. Lee, B. Xu, C.-H. Lee, J.-Y. Ahn, M. S. Song, H. Lee, C. E. Canman, J.-S. Lee, M. B. Kastan, and D.-S. Lim (2003)
Mol. Cancer Res. 1, 674-681
   Abstract »    Full Text »    PDF »


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