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Science 6 December 1996:
Vol. 274. no. 5293, pp. 1659 - 1663
DOI: 10.1126/science.274.5293.1659
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Articles

Cell Cycle Control of DNA Replication

Bruce Stillman

The initiation of DNA replication in eukaryotic cells is a highly regulated process that leads to the duplication of the genetic information for the next cell generation. This requires the ordered assembly of many proteins at the origins of DNA replication to form a competent, pre-replicative chromosomal state. In addition to this competent complex, at least two cell cycle regulated protein kinase pathways are required to affect a transition to a post-replicative chromosomal state. Protein kinases required to establish mitosis prevent re-replication of the DNA. As cells exit mitosis, the cell cycle is reset, allowing the establishment of a new, competent replication state.

The author is at the Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724, USA.

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   Abstract »    Full Text »    PDF »
Cell Cycle-Regulated Expression of Mammalian CDC6 Is Dependent on E2F.
G. Hateboer, A. Wobst, B. O. Petersen, L. Le Cam, E. Vigo, C. Sardet, and K. Helin (1998)
Mol. Cell. Biol. 18, 6679-6697
   Abstract »    Full Text »
Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex.
P. B. Carpenter and W. G. Dunphy (1998)
J. Biol. Chem. 273, 24891-24897
   Abstract »    Full Text »    PDF »
The structural protein ODV-EC27 of Autographa californica nucleopolyhedrovirus is a multifunctional viral cyclin.
M. Belyavskyi, S. C. Braunagel, and M. D. Summers (1998)
PNAS 95, 11205-11210
   Abstract »    Full Text »    PDF »
Growth Regulation of the Expression of Mouse cDNA and Gene Encoding a Serine/Threonine Kinase Related to Saccharomyces cerevisiae CDC7 Essential for G1/S Transition. STRUCTURE, CHROMOSOMAL LOCALIZATION, AND EXPRESSION OF MOUSE GENE FOR S. CEREVISIAE CDC7-RELATED KINASE.
J. M. Kim, N. Sato, M. Yamada, K.-i. Arai, and H. Masai (1998)
J. Biol. Chem. 273, 23248-23257
   Abstract »    Full Text »    PDF »
Purification of Hsk1, a Minichromosome Maintenance Protein Kinase from Fission Yeast.
G. W. Brown and T. J. Kelly (1998)
J. Biol. Chem. 273, 22083-22090
   Abstract »    Full Text »    PDF »
Genetic Dissection of a Mammalian Replicator in the Human beta -Globin Locus.
M. I. Aladjem, L. W. Rodewald, J. L. Kolman, and G. M. Wahl (1998)
Science 281, 1005-1009
   Abstract »    Full Text »
Mutational Effect of Fission Yeast Polalpha on Cell Cycle Events.
D. Bhaumik and T. S.-F. Wang (1998)
Mol. Biol. Cell 9, 2107-2123
   Abstract »    Full Text »
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
G. Leone, J. DeGregori, Z. Yan, L. Jakoi, S. Ishida, R. S. Williams, and J. R. Nevins (1998)
Genes & Dev. 12, 2120-2130
   Abstract »    Full Text »
Structures of Apurinic and Apyrimidinic Sites in Duplex DNAs.
R. D. Beger and P. H. Bolton (1998)
J. Biol. Chem. 273, 15565-15573
   Abstract »    Full Text »    PDF »


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