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Science 15 November 1996:
Vol. 274. no. 5290, pp. 1133 - 1138
DOI: 10.1126/science.274.5290.1133
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Articles

Synaptic Activity and the Construction of Cortical Circuits

L. C. Katz * and C. J. Shatz

Vision is critical for the functional and structural maturation of connections in the mammalian visual system. Visual experience, however, is a subset of a more general requirement for neural activity in transforming immature circuits into the organized connections that subserve adult brain function. Early in development, internally generated spontaneous activity sculpts circuits on the basis of the brain's "best guess" at the initial configuration of connections necessary for function and survival. With maturation of the sense organs, the developing brain relies less on spontaneous activity and increasingly on sensory experience. The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.

L. C. Katz is with the Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. C. J. Shatz is with the Howard Hughes Medical Institute and the Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
*   To whom correspondence should be addressed. E-mail:larry{at}neuro.duke.edu

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Delayed development of adult-generated granule cells in dentate gyrus..
L. S. Overstreet-Wadiche, A. L. Bensen, and G. L. Westbrook (2006)
J. Neurosci. 26, 2326-2334
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Science. ISSN 0036-8075 (print), 1095-9203 (online)