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Science 15 November 1996:
Vol. 274. no. 5290, pp. 1123 - 1133
DOI: 10.1126/science.274.5290.1123
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Articles

The Molecular Biology of Axon Guidance

Marc Tessier-Lavigne and Corey S. Goodman

Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.

M. Tessier-Lavigne is in the Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA. C. S. Goodman is in the Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

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SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.
B. Itoh, T. Hirose, N. Takata, K. Nishiwaki, M. Koga, Y. Ohshima, and M. Okada (2005)
Development 132, 5161-5172
   Abstract »    Full Text »    PDF »
cAMP Differentially Regulates Axonal and Dendritic Development of Dentate Granule Cells.
R. X. Yamada, N. Matsuki, and Y. Ikegaya (2005)
J. Biol. Chem. 280, 38020-38028
   Abstract »    Full Text »    PDF »
Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons.
T. C. Fleming, F. W. Wolf, and G. Garriga (2005)
Development 132, 4857-4867
   Abstract »    Full Text »    PDF »
Adaptation is not required to explain the long-term response of axons to molecular gradients.
J. Xu, W. J. Rosoff, J. S. Urbach, and G. J. Goodhill (2005)
Development 132, 4545-4552
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)