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Science 8 November 1996:
Vol. 274. no. 5289, pp. 995 - 998
DOI: 10.1126/science.274.5289.995
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Reports

Hypertension Induced in Pregnant Mice by Placental Renin and Maternal Angiotensinogen

Eriko Takimoto, Junji Ishida, Fumihiro Sugiyama, Hisashi Horiguchi, Kazuo Murakami, Akiyoshi Fukamizu *

Maternal hypertension is a common complication of pregnancy and its pathophysiology is poorly understood. This phenomenon was studied in an animal model by mating transgenic mice expressing components of the human renin-angiotensin system. When transgenic females expressing angiotensinogen were mated with transgenic males expressing renin, the pregnant females displayed a transient elevation of blood pressure in late pregnancy, due to secretion of placental human renin into the maternal circulation. Blood pressure returned to normal levels after delivery of the pups. Histopathologic examination revealed uniform enlargement of glomeruli associated with an increase in urinary protein excretion, myocardial hypertrophy, and necrosis and edema in the placenta. These mice may provide molecular insights into pregnancy-associated hypertension in humans.

E. Takimoto, J. Ishida, K. Murakami, A. Fukamizu, Institute of Applied Biochemistry and Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki 305, Japan.
F. Sugiyama, Laboratory Animal Research Center, University of Tsukuba, Ibaraki 305, Japan.
H. Horiguchi, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki 305, Japan.
*   To whom correspondence should be addressed. E-mail: akif{at}sakura.cc.tsukuba.ac.jp

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