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Science 1 November 1996:
Vol. 274. no. 5288, pp. 798 - 801
DOI: 10.1126/science.274.5288.798
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Reports

Hyperresponsive B Cells in CD22-Deficient Mice

Theresa L. O'Keefe, Gareth T. Williams, Sarah L. Davies, Michael S. Neuberger *

CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. Splenic B cells from mice with a disrupted CD22 gene were found to be hyperresponsive to receptor signaling: Heightened calcium fluxes and cell proliferation were obtained at lower ligand concentrations. The mice gave an augmented immune response, had an expanded peritoneal B-1 cell population, and contained increased serum titers of autoantibody. Thus, CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
Loss of N-Glycolylneuraminic Acid in Human Evolution. IMPLICATIONS FOR SIALIC ACID RECOGNITION BY SIGLECS.
E. C. M. Brinkman-Van der Linden, E. R. Sjoberg, L. R. Juneja, P. R. Crocker, N. Varki, and A. Varki (2000)
J. Biol. Chem. 275, 8633-8640
   Abstract »    Full Text »    PDF »
CD72 Negatively Regulates Signaling Through the Antigen Receptor of B Cells.
T. Adachi, C. Wakabayashi, T. Nakayama, H. Yakura, and T. Tsubata (2000)
J. Immunol. 164, 1223-1229
   Abstract »    Full Text »    PDF »
Murine B cell differentiation is accompanied by programmed expression of multiple novel {beta}-galactoside {alpha}2,6-sialyltransferase mRNA forms.
S. A. Wuensch, R. Y. Huang, J. Ewing, X. Liang, and J. T. Y. Lau (2000)
Glycobiology 10, 67-75
   Abstract »    Full Text »    PDF »
Genetic Evidence for Lyn as a Negative Regulator of IL-4 Signaling.
M. L. Janas, P. Hodgkin, M. Hibbs, and D. Tarlinton (1999)
J. Immunol. 163, 4192-4198
   Abstract »    Full Text »    PDF »
Human Hematopoietic Stem/Progenitor Cells Generate CD5+ B Lymphoid Cells in NOD/SCID Mice.
E. M. Novelli, M. Ramírez, W. Leung, and C. I. Civin (1999)
Stem Cells 17, 242-252
   Abstract »    Full Text »
CD22 Cross-Linking Generates B-Cell Antigen Receptor-Independent Signals That Activate the JNK/SAPK Signaling Cascade.
J. M. Tuscano, A. Riva, S. N. Toscano, T. F. Tedder, and J. H. Kehrl (1999)
Blood 94, 1382-1392
   Abstract »    Full Text »    PDF »
Analysis of Tyrosine Phosphorylation-dependent Interactions between Stimulatory Effector Proteins and the B Cell Co-receptor CD22.
J. Yohannan, J. Wienands, K. M. Coggeshall, and L. B. Justement (1999)
J. Biol. Chem. 274, 18769-18776
   Abstract »    Full Text »    PDF »
Genetic Dissection of Sle Pathogenesis: Sle3 on Murine Chromosome 7 Impacts T Cell Activation, Differentiation, and Cell Death.
C. Mohan, Y. Yu, L. Morel, P. Yang, and E. K. Wakeland (1999)
J. Immunol. 162, 6492-6502
   Abstract »    Full Text »    PDF »
Identification of CD22 Ligands on Bone Marrow Sinusoidal Endothelium Implicated in CD22-dependent Homing of Recirculating B Cells.
L. Nitschke, H. Floyd, D. J.P. Ferguson, and P. R. Crocker (1999)
J. Exp. Med. 189, 1513-1518
   Abstract »    Full Text »    PDF »
CD45 Regulates Tyrosine Phosphorylation of CD22 and Its Association with the Protein Tyrosine Phosphatase SHP-1.
S. F. Greer and L. B. Justement (1999)
J. Immunol. 162, 5278-5286
   Abstract »    Full Text »    PDF »
Deficiency in CD22, a B Cell-specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies.
T. L. O'Keefe, G. T. Williams, F. D. Batista, and M. S. Neuberger (1999)
J. Exp. Med. 189, 1307-1313
   Abstract »    Full Text »    PDF »
Production of High Affinity Autoantibodies in Autoimmune New Zealand Black/New Zealand White F1 Mice Targeted with an Anti-DNA Heavy Chain.
D. Friedmann, N. Yachimovich, G. Mostoslavsky, Y. Pewzner-Jung, A. Ben-Yehuda, K. Rajewsky, and D. Eilat (1999)
J. Immunol. 162, 4406-4416
   Abstract »    Full Text »    PDF »
Accelerated Emigration of B Lymphocytes in the Xid Mouse.
A. Cariappa, T. J. Kim, and S. Pillai (1999)
J. Immunol. 162, 4417-4423
   Abstract »    Full Text »    PDF »
CD14 Plays No Major Role in Shock Induced by Staphylococcus aureus but Down-Regulates TNF-{alpha} Production.
A. Haziot, N. Hijiya, K. Schultz, F. Zhang, S. C. Gangloff, and S. M. Goyert (1999)
J. Immunol. 162, 4801-4805
   Abstract »    Full Text »    PDF »
Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system.
N. Baumgarth, O. C. Herman, G. C. Jager, L. Brown, L. A. Herzenberg, and L. A. Herzenberg (1999)
PNAS 96, 2250-2255
   Abstract »    Full Text »    PDF »
Definition of the Sites of Interaction between the Protein Tyrosine Phosphatase SHP-1 and CD22.
J. Blasioli, S. Paust, and M. L. Thomas (1999)
J. Biol. Chem. 274, 2303-2307
   Abstract »    Full Text »    PDF »


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