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Science 1 November 1996:
Vol. 274. no. 5288, pp. 787 - 789
DOI: 10.1126/science.274.5288.787
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Reports

Suppression of TNF-alpha -Induced Apoptosis by NF-kappa B

Daniel J. Van Antwerp, Seamus J. Martin, * Tal Kafri, Douglas R. Green, Inder M. Verma dagger

Tumor necrosis factor alpha  (TNF-alpha ) signaling gives rise to a number of events, including activation of transcription factor NF-kappa B and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha -induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative Ikappa Balpha (Ikappa Balpha M). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappa B activation suppresses the signals for cell death.

D. J. Van Antwerp, Laboratory of Genetics, Salk Institute, La Jolla, CA 92037, and Department of Chemistry and Biochemistry, University of California, San Diego, CA 92093, USA.
S. J. Martin and D. R. Green, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.
T. Kafri and I. M. Verma, Laboratory of Genetics, Salk Institute, La Jolla, CA 92037, USA.
*   Present address: Molecular Cell Biology Laboratory, Department of Biology, Maynooth College, Maynooth, County Kildare, Ireland.

dagger    To whom correspondence should be addressed.

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Suppression of Calcium Release from Inositol 1,4,5-Trisphosphate-sensitive Stores Mediates the Anti-apoptotic Function of Nuclear Factor-{kappa}B.
S. Camandola, R. G. Cutler, D. S. Gary, O. Milhavet, and M. P. Mattson (2005)
J. Biol. Chem. 280, 22287-22296
   Abstract »    Full Text »    PDF »
Apoptosis Induction by a Novel Retinoid-Related Molecule Requires Nuclear Factor-{kappa}B Activation.
L. Farhana, M. I. Dawson, and J. A. Fontana (2005)
Cancer Res. 65, 4909-4917
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Cooperative Cytotoxicity of Proteasome Inhibitors and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Chemoresistant Bcl-2-Overexpressing Cells.
A. Nencioni, L. Wille, G. Dal Bello, D. Boy, G. Cirmena, S. Wesselborg, C. Belka, P. Brossart, F. Patrone, and A. Ballestrero (2005)
Clin. Cancer Res. 11, 4259-4265
   Abstract »    Full Text »    PDF »
1'-Acetoxychavicol Acetate Is a Novel Nuclear Factor {kappa}B Inhibitor with Significant Activity against Multiple Myeloma In vitro and In vivo.
K. Ito, T. Nakazato, M. J. Xian, T. Yamada, N. Hozumi, A. Murakami, H. Ohigashi, Y. Ikeda, and M. Kizaki (2005)
Cancer Res. 65, 4417-4424
   Abstract »    Full Text »    PDF »
Human RPE Expression of Cell Survival Factors.
P. Yang, J. L. Wiser, J. J. Peairs, J. N. Ebright, Z. J. Zavodni, C. Bowes Rickman, and G. J. Jaffe (2005)
Invest. Ophthalmol. Vis. Sci. 46, 1755-1764
   Abstract »    Full Text »    PDF »
Function of Polo-like Kinase 3 in NF-{kappa}B-mediated Proapoptotic Response.
Z. Li, J. Niu, T. Uwagawa, B. Peng, and P. J. Chiao (2005)
J. Biol. Chem. 280, 16843-16850
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Apoptosis Induced by the Toll-Like Receptor Adaptor TRIF Is Dependent on Its Receptor Interacting Protein Homotypic Interaction Motif.
W. J. Kaiser and M. K. Offermann (2005)
J. Immunol. 174, 4942-4952
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Analysis of Genes Induced by Sendai Virus Infection of Mutant Cell Lines Reveals Essential Roles of Interferon Regulatory Factor 3, NF-{kappa}B, and Interferon but Not Toll-Like Receptor 3.
C. P. Elco, J. M. Guenther, B. R. G. Williams, and G. C. Sen (2005)
J. Virol. 79, 3920-3929
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TFII-I Regulates Induction of Chromosomally Integrated Human Immunodeficiency Virus Type 1 Long Terminal Repeat in Cooperation with USF.
J. Chen, T. Malcolm, M. C. Estable, R. G. Roeder, and I. Sadowski (2005)
J. Virol. 79, 4396-4406
   Abstract »    Full Text »    PDF »
Serum Deprivation Induces Apoptotic Cell Death of Transformed Rat Retinal Ganglion Cells via Mitochondrial Signaling Pathways.
I. Charles, A. Khalyfa, D. M. Kumar, R. R. Krishnamoorthy, R. S. Roque, N. Cooper, and N. Agarwal (2005)
Invest. Ophthalmol. Vis. Sci. 46, 1330-1338
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Identification of the Genes Involved in Enhanced Fenretinide-Induced Apoptosis by Parthenolide in Human Hepatoma Cells.
J.-H. Park, L. Liu, I.-H. Kim, J.-H. Kim, K.-R. You, and D.-G. Kim (2005)
Cancer Res. 65, 2804-2814
   Abstract »    Full Text »    PDF »
CDK4 regulation by TNFR1 and JNK is required for NF-{kappa}B-mediated epidermal growth control.
J. Y. Zhang, S. Tao, R. Kimmel, and P. A. Khavari (2005)
J. Cell Biol. 168, 561-566
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RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-{alpha} and NF-{kappa}B.
G. Cataldegirmen, S. Zeng, N. Feirt, N. Ippagunta, H. Dun, W. Qu, Y. Lu, L. L. Rong, M. A. Hofmann, T. Kislinger, et al. (2005)
J. Exp. Med. 201, 473-484
   Abstract »    Full Text »    PDF »
Antiapoptotic Effect of Serum and Glucocorticoid-Inducible Protein Kinase Is Mediated by Novel Mechanism Activating I{kappa}B Kinase.
L. Zhang, R. Cui, X. Cheng, and J. Du (2005)
Cancer Res. 65, 457-464
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Targeting NF-{kappa}B activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.
C. Frelin, V. Imbert, E. Griessinger, A.-C. Peyron, N. Rochet, P. Philip, C. Dageville, A. Sirvent, M. Hummelsberger, E. Berard, et al. (2005)
Blood 105, 804-811
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Tumor necrosis factor-{alpha} stimulates gastric epithelial cell proliferation.
J. C. Luo, V. Y. Shin, Y. H. Yang, W. K. K. Wu, Y. N. Ye, W. H. L. So, F. Y. Chang, and C. H. Cho (2005)
Am J Physiol Gastrointest Liver Physiol 288, G32-G38
   Abstract »    Full Text »    PDF »
Efficient Replication by Herpes Simplex Virus Type 1 Involves Activation of the I{kappa}B Kinase-I{kappa}B-p65 Pathway.
D. Gregory, D. Hargett, D. Holmes, E. Money, and S. L. Bachenheimer (2004)
J. Virol. 78, 13582-13590
   Abstract »    Full Text »    PDF »
Agents with Selective Estrogen Receptor (ER) Modulator Activity Induce Apoptosis In vitro and In vivo in ER-Negative Glioma Cells.
A.-M. Hui, W. Zhang, W. Chen, D. Xi, B. Purow, G. C. Friedman, and H. A. Fine (2004)
Cancer Res. 64, 9115-9123
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Inhibition of MAPK Signaling Pathways by VopA from Vibrio parahaemolyticus.
J. E. Trosky, S. Mukherjee, D. L. Burdette, M. Roberts, L. McCarter, R. M. Siegel, and K. Orth (2004)
J. Biol. Chem. 279, 51953-51957
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Identification and Characterization of the IKK{alpha} Promoter: POSITIVE AND NEGATIVE REGULATION BY ETS-1 AND p53, RESPECTIVELY.
L. Gu, N. Zhu, H. W. Findley, W. G. Woods, and M. Zhou (2004)
J. Biol. Chem. 279, 52141-52149
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Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression.
C. Oberholzer, A. Oberholzer, S. K. Tschoeke, R. M. Minter, F. R. Bahjat, D. LaFace, B. Hutchins, and L. L. Moldawer (2004)
Innate Immunity 10, 393-401
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Available human feeder cells for the maintenance of human embryonic stem cells.
J. B. Lee, J. M. Song, J. E. Lee, J. H. Park, S. J. Kim, S. M. Kang, J. N. Kwon, M. K. Kim, S. I. Roh, and H. S. Yoon (2004)
Reproduction 128, 727-735
   Abstract »    Full Text »    PDF »
Prevention of Spontaneous and Experimentally Induced Diabetes in Mice With Zinc Sulfate-Enriched Drinking Water Is Associated with Activation and Reduction of NF-{kappa}B and AP-1 in Islets, Respectively.
P. Schott-Ohly, A. Lgssiar, H.-J. Partke, M. Hassan, N. Friesen, and H. Gleichmann (2004)
Experimental Biology and Medicine 229, 1177-1185
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JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species.
J.-J. Ventura, P. Cogswell, R. A. Flavell, A. S. Baldwin Jr., and R. J. Davis (2004)
Genes & Dev. 18, 2905-2915
   Abstract »    Full Text »    PDF »


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