Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 November 1996:
Vol. 274. no. 5288, pp. 784 - 787
DOI: 10.1126/science.274.5288.784
Prev | Table of Contents | Next

Reports

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-kappa B

Cun-Yu Wang, Marty W. Mayo, Albert S. Baldwin Jr. *

Many cells are resistant to stimuli that can induce apoptosis, but the mechanisms involved are not fully understood. The activation of the transcription factor nuclear factor-kappa B (NF-kappa B) by tumor necrosis factor (TNF), ionizing radiation, or daunorubicin (a cancer chemotherapeutic compound), was found to protect from cell killing. Inhibition of NF-kappa B nuclear translocation enhanced apoptotic killing by these reagents but not by apoptotic stimuli that do not activate NF-kappa B. These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-kappa B, and have potential for improvement of the efficacy of cancer therapies.

C.-Y. Wang, Curriculum in Genetics and Molecular Biology and Department of Endodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
M. W. Mayo, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
A. S. Baldwin Jr., Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biology, University of North Carolina, Chapel Hill, NC 27599-7295.
*   To whom correspondence should be addressed at Lineberger Comprehensive Cancer Center, Campus Box 7295, University of North Carolina, Chapel Hill, NC 27599, USA.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-{kappa}B Activation and Up-Regulation of c-FLIP and Bcl-xL.
M. Travert, P. Ame-Thomas, C. Pangault, A. Morizot, O. Micheau, G. Semana, T. Lamy, T. Fest, K. Tarte, and T. Guillaudeux (2008)
J. Immunol. 181, 1001-1011
   Abstract »    Full Text »    PDF »
A Distinctive Physiological Role for I{kappa}B{beta} in the Propagation of Mitochondrial Respiratory Stress Signaling.
G. Biswas, W. Tang, N. Sondheimer, M. Guha, S. Bansal, and N. G. Avadhani (2008)
J. Biol. Chem. 283, 12586-12594
   Abstract »    Full Text »    PDF »
Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to {gamma}-Radiation by Targeting Nuclear Factor-{kappa}B-Regulated Gene Products.
A. B. Kunnumakkara, P. Diagaradjane, S. Guha, A. Deorukhkar, S. Shentu, B. B. Aggarwal, and S. Krishnan (2008)
Clin. Cancer Res. 14, 2128-2136
   Abstract »    Full Text »    PDF »
HO-1 underlies resistance of AML cells to TNF-induced apoptosis.
S. A. Rushworth and D. J. MacEwan (2008)
Blood 111, 3793-3801
   Abstract »    Full Text »    PDF »
Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade.
R. Z. Orlowski and D. J. Kuhn (2008)
Clin. Cancer Res. 14, 1649-1657
   Abstract »    Full Text »    PDF »
Targeting the Nuclear Factor-{kappa}B Rescue Pathway Has Promising Future in Human Renal Cell Carcinoma Therapy.
C. Sourbier, S. Danilin, V. Lindner, J. Steger, S. Rothhut, N. Meyer, D. Jacqmin, J.-J. Helwig, H. Lang, and T. Massfelder (2007)
Cancer Res. 67, 11668-11676
   Abstract »    Full Text »    PDF »
Effects of Organ Culture and Optisol-GS Storage on Structural Integrity, Phenotypes, and Apoptosis in Cultured Corneal Epithelium.
S. Raeder, T. P. Utheim, O. A. Utheim, B. Nicolaissen, B. Roald, Y. Cai, K. Haug, A. Kvalheim, E. B. Messelt, L. Drolsum, et al. (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5484-5493
   Abstract »    Full Text »    PDF »
Adenovirally Delivered Tumor Necrosis Factor-{alpha} Improves the Antiglioma Efficacy of Concomitant Radiation and Temozolomide Therapy.
B. Yamini, X. Yu, P. Pytel, N. Galanopoulos, V. Rawlani, J. Veerapong, K. Bickenbach, and R. R. Weichselbaum (2007)
Clin. Cancer Res. 13, 6217-6223
   Abstract »    Full Text »    PDF »
Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.
A. White, D. Carragher, S. Parnell, A. Msaki, N. Perkins, P. Lane, E. Jenkinson, G. Anderson, and J. H. Caamano (2007)
Blood 110, 1950-1959
   Abstract »    Full Text »    PDF »
Nuclear factor {kappa}B as a target for new drug development in myeloid malignancies.
D. Cilloni, G. Martinelli, F. Messa, M. Baccarani, and G. Saglio (2007)
Haematologica 92, 1224-1229
   Abstract »    Full Text »    PDF »
NFBD1/MDC1 Associates with p53 and Regulates Its Function at the Crossroad between Cell Survival and Death in Response to DNA Damage.
M. Nakanishi, T. Ozaki, H. Yamamoto, T. Hanamoto, H. Kikuchi, K. Furuya, M. Asaka, D. Delia, and A. Nakagawara (2007)
J. Biol. Chem. 282, 22993-23004
   Abstract »    Full Text »    PDF »
Tumor necrosis factor-{alpha} is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction.
Y. Monden, T. Kubota, T. Inoue, T. Tsutsumi, S. Kawano, T. Ide, H. Tsutsui, and K. Sunagawa (2007)
Am J Physiol Heart Circ Physiol 293, H743-H753
   Abstract »    Full Text »    PDF »
Stabilization of p73 by Nuclear I{kappa}B Kinase-{alpha} Mediates Cisplatin-induced Apoptosis.
K. Furuya, T. Ozaki, T. Hanamoto, M. Hosoda, S. Hayashi, P. A. Barker, K. Takano, M. Matsumoto, and A. Nakagawara (2007)
J. Biol. Chem. 282, 18365-18378
   Abstract »    Full Text »    PDF »
Regulation of the G2-M cell cycle progression by the ERK5-NF{kappa}B signaling pathway.
K. Cude, Y. Wang, H.-J. Choi, S.-L. Hsuan, H. Zhang, C.-Y. Wang, and Z. Xia (2007)
J. Cell Biol. 177, 253-264
   Abstract »    Full Text »    PDF »
Transgenic Expression of A20 Prevents Cardiac Cell Death and Myocardial Dysfunction After Myocardial Infarction.
J. Shaw, I. A. Eydelnant, and L. A. Kirshenbaum (2007)
Circulation 115, 1827-1829
   Full Text »    PDF »
Nuclear Factor-{kappa}B and Manganese Superoxide Dismutase Mediate Adaptive Radioresistance in Low-Dose Irradiated Mouse Skin Epithelial Cells.
M. Fan, K. M. Ahmed, M. C. Coleman, D. R. Spitz, and J. J. Li (2007)
Cancer Res. 67, 3220-3228
   Abstract »    Full Text »    PDF »
Inhibition of nuclear factor-{kappa}B augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activation.
Y. Oida, B. Gopalan, R. Miyahara, C. D. Branch, P. Chiao, S. Chada, and R. Ramesh (2007)
Mol. Cancer Ther. 6, 1440-1449
   Abstract »    Full Text »    PDF »
Focal adhesion kinase mediates cell survival via NF-{kappa}B and ERK signaling pathways.
D. Huang, M. Khoe, M. Befekadu, S. Chung, Y. Takata, D. Ilic, and M. Bryer-Ash (2007)
Am J Physiol Cell Physiol 292, C1339-C1352
   Abstract »    Full Text »    PDF »
Green Tea Polyphenol Administration Partly Ameliorates Chemotherapy-Induced Side Effects in the Small Intestine of Mice.
B. Wessner, E.-M. Strasser, N. Koitz, C. Schmuckenschlager, N. Unger-Manhart, and E. Roth (2007)
J. Nutr. 137, 634-640
   Abstract »    Full Text »    PDF »
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis.
I. Kryczek, S. Wei, E. Keller, R. Liu, and W. Zou (2007)
Am J Physiol Cell Physiol 292, C987-C995
   Abstract »    Full Text »    PDF »
NF-{kappa}B prevents beta cell death and autoimmune diabetes in NOD mice.
S. Kim, I. Millet, H. S. Kim, J. Y. Kim, M. S. Han, M.-K. Lee, K.-W. Kim, R. S. Sherwin, M. Karin, and M.-S. Lee (2007)
PNAS 104, 1913-1918
   Abstract »    Full Text »    PDF »
Viral protease cleavage of inhibitor of {kappa}B{alpha} triggers host cell apoptosis.
C. Zaragoza, M. Saura, E. Y. Padalko, E. Lopez-Rivera, T. R. Lizarbe, S. Lamas, and C. J. Lowenstein (2006)
PNAS 103, 19051-19056
   Abstract »    Full Text »    PDF »
Wogonin sensitizes resistant malignant cells to TNF{alpha}- and TRAIL-induced apoptosis.
S. C. Fas, S. Baumann, J. Y. Zhu, M. Giaisi, M. K. Treiber, U. Mahlknecht, P. H. Krammer, and M. Li-Weber (2006)
Blood 108, 3700-3706
   Abstract »    Full Text »    PDF »
NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model..
J. C. Cusack Jr., R. Liu, L. Xia, T.-H. Chao, C. Pien, W. Niu, V. J. Palombella, S. T.C. Neuteboom, and M. A. Palladino (2006)
Clin. Cancer Res. 12, 6758-6764
   Abstract »    Full Text »    PDF »
A Dominant Function of IKK/NF-{kappa}B Signaling in Global Lipopolysaccharide-induced Gene Expression.
N. Carayol, J. Chen, F. Yang, T. Jin, L. Jin, D. States, and C.-Y. Wang (2006)
J. Biol. Chem. 281, 31142-31151
   Abstract »    Full Text »    PDF »
Endoplasmic reticulum stress signaling in disease..
S. J. Marciniak and D. Ron (2006)
Physiol Rev 86, 1133-1149
   Abstract »    Full Text »    PDF »
Inhibition of cell growth and nuclear factor-{kappa}B activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503..
H.-S. Shiah, W. Gao, D. C. Baker, and Y.-C. Cheng (2006)
Mol. Cancer Ther. 5, 2484-2493
   Abstract »    Full Text »    PDF »
Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis.
K. Miller-Jensen, K. A. Janes, Y.-L. Wong, L. G. Griffith, and D. A. Lauffenburger (2006)
J. Cell Sci. 119, 3788-3798
   Abstract »    Full Text »    PDF »
Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor-{kappa}B Activation Pathway.
K. S. Ahn, G. Sethi, S. Shishodia, B. Sung, J. L. Arbiser, and B. B. Aggarwal (2006)
Mol. Cancer Res. 4, 621-633
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B Regulates {beta}-Cell Death: A Critical Role for A20 in {beta}-Cell Protection.
D. Liuwantara, M. Elliot, M. W. Smith, A. O. Yam, S. N. Walters, E. Marino, A. McShea, and S. T. Grey (2006)
Diabetes 55, 2491-2501
   Abstract »    Full Text »    PDF »
Nuclear factor-{kappa}B maintains TRAIL resistance in human pancreatic cancer cells..
S. Khanbolooki, S. T. Nawrocki, T. Arumugam, R. Andtbacka, M. S. Pino, R. Kurzrock, C. D. Logsdon, J. L. Abbruzzese, and D. J. McConkey (2006)
Mol. Cancer Ther. 5, 2251-2260
   Abstract »    Full Text »    PDF »
Discoidin Domain Receptor 1 Receptor Tyrosine Kinase Induces Cyclooxygenase-2 and Promotes Chemoresistance through Nuclear Factor-{kappa}B Pathway Activation.
S. Das, P. P. Ongusaha, Y. S. Yang, J.-M. Park, S. A. Aaronson, and S. W. Lee (2006)
Cancer Res. 66, 8123-8130
   Abstract »    Full Text »    PDF »
CD40 Ligation Protects Bronchial Epithelium against Oxidant-Induced Caspase-Independent Cell Death.
A. M. Merendino, F. Bucchieri, R. Gagliardo, A. Daryadel, F. Pompeo, G. Chiappara, R. Santagata, V. Bellia, S. David, F. Farina, et al. (2006)
Am. J. Respir. Cell Mol. Biol. 35, 155-164
   Abstract »    Full Text »    PDF »
Specific Recognition of Apoptotic Cells Reveals a Ubiquitous and Unconventional Innate Immunity.
M. Cvetanovic, J. E. Mitchell, V. Patel, B. S. Avner, Y. Su, P. T. van der Saag, P. L. Witte, S. Fiore, J. S. Levine, and D. S. Ucker (2006)
J. Biol. Chem. 281, 20055-20067
   Abstract »    Full Text »    PDF »
IL-1beta decreases the elastic modulus of human tenocytes.
J. Qi, A. M. Fox, L. G. Alexopoulos, L. Chi, D. Bynum, F. Guilak, and A. J. Banes (2006)
J Appl Physiol 101, 189-195
   Abstract »    Full Text »    PDF »
The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas.
L. Bernal-Mizrachi, C. M. Lovly, and L. Ratner (2006)
PNAS 103, 9220-9225
   Abstract »    Full Text »    PDF »
Activation of nuclear factor-{kappa} B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients..
C Montagut, I Tusquets, B Ferrer, J M Corominas, B Bellosillo, C Campas, M Suarez, X Fabregat, E Campo, P Gascon, et al. (2006)
Endocr. Relat. Cancer 13, 607-616
   Abstract »    Full Text »    PDF »
Protein Methyltransferase 2 Inhibits NF-{kappa}B Function and Promotes Apoptosis.
L. Ganesh, T. Yoshimoto, N. C. Moorthy, W. Akahata, M. Boehm, E. G. Nabel, and G. J. Nabel (2006)
Mol. Cell. Biol. 26, 3864-3874
   Abstract »    Full Text »    PDF »
Malignant Transformation of Immortalized HaCaT Keratinocytes through Deregulated Nuclear Factor {kappa}B Signaling..
Q. Ren, C. Kari, M. R.D. Quadros, R. Burd, P. McCue, A. P. Dicker, and U. Rodeck (2006)
Cancer Res. 66, 5209-5215
   Abstract »    Full Text »    PDF »
The Combination of the Proteasome Inhibitor Bortezomib and the Bcl-2 Antisense Molecule Oblimersen Sensitizes Human B-Cell Lymphomas to Cyclophosphamide..
O. A. O'Connor, E. A. Smith, L. E. Toner, J. Teruya-Feldstein, S. Frankel, M. Rolfe, X. Wei, S. Liu, G. Marcucci, K. K. Chan, et al. (2006)
Clin. Cancer Res. 12, 2902-2911
   Abstract »    Full Text »    PDF »
Inhibition of Hepatocarcinogenesis by the Deletion of the p50 Subunit of NF-{kappa}B in Mice Administered the Peroxisome Proliferator Wy-14,643.
H. P. Glauert, A. Eyigor, J. C. Tharappel, S. Cooper, E. Y. Lee, and B. T. Spear (2006)
Toxicol. Sci. 90, 331-336
   Abstract »    Full Text »    PDF »
C-Peptide Signals via G{alpha}i to Protect against TNF-{alpha}-Mediated Apoptosis of Opossum Kidney Proximal Tubular Cells.
N. M. Al-Rasheed, G. B. Willars, and N. J. Brunskill (2006)
J. Am. Soc. Nephrol. 17, 986-995
   Abstract »    Full Text »    PDF »
Antianoikis Effect of Nuclear Factor-{kappa}B through Up-regulated Expression of Osteoprotegerin, BCL-2, and IAP-1.
M. Toruner, M. Fernandez-Zapico, J. J. Sha, L. Pham, R. Urrutia, and L. J. Egan (2006)
J. Biol. Chem. 281, 8686-8696
   Abstract »    Full Text »    PDF »
A Synthetic Triterpenoid, CDDO-Me, Inhibits I{kappa}B{alpha} Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor {kappa}B-Regulated Gene Products in Human Leukemic Cells.
S. Shishodia, G. Sethi, M. Konopleva, M. Andreeff, and B. B. Aggarwal (2006)
Clin. Cancer Res. 12, 1828-1838
   Abstract »    Full Text »    PDF »
The proteasome is required for rapid initiation of death receptor-induced apoptosis..
D. Sohn, G. Totzke, F. Essmann, K. Schulze-Osthoff, B. Levkau, and R. U. Janicke (2006)
Mol. Cell. Biol. 26, 1967-1978
   Abstract »    Full Text »    PDF »
Glucocorticoids enhance cytotoxicity of cisplatin via suppression of NF-{kappa}B activation in the glucocorticoid receptor-rich human cervical carcinoma cell line SiHa.
Y.-S. Lu, P.-Y. Yeh, S.-E. Chuang, M. Gao, M.-L. Kuo, and A.-L. Cheng (2006)
J. Endocrinol. 188, 311-319
   Abstract »    Full Text »    PDF »
Lovastatin Protects Human Endothelial Cells from Killing by Ionizing Radiation without Impairing Induction and Repair of DNA Double-Strand Breaks.
T. Nubel, J. Damrot, W. P. Roos, B. Kaina, and G. Fritz (2006)
Clin. Cancer Res. 12, 933-939
   Abstract »    Full Text »    PDF »
Late Activation of Stress Kinases (SAPK/JNK) by Genotoxins Requires the DNA Repair Proteins DNA-PKcs and CSB.
G. Fritz and B. Kaina (2006)
Mol. Biol. Cell 17, 851-861
   Abstract »    Full Text »    PDF »
A Splice Variant of Stress Response Gene ATF3 Counteracts NF-{kappa}B-dependent Anti-apoptosis through Inhibiting Recruitment of CREB-binding Protein/p300 Coactivator.
B. Hua, M. Tamamori-Adachi, Y. Luo, K. Tamura, M. Morioka, M. Fukuda, Y. Tanaka, and S. Kitajima (2006)
J. Biol. Chem. 281, 1620-1629
   Abstract »    Full Text »    PDF »
Enhancement of Sensitivity to Tumor Necrosis Factor {alpha} in Non-Small Cell Lung Cancer Cells with Acquired Resistance to Gefitinib.
K. Ando, T. Ohmori, F. Inoue, T. Kadofuku, T. Hosaka, H. Ishida, T. Shirai, K. Okuda, T. Hirose, N. Horichi, et al. (2005)
Clin. Cancer Res. 11, 8872-8879
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B-Mediated Cell Survival Involves Transcriptional Silencing of the Mitochondrial Death Gene BNIP3 in Ventricular Myocytes.
D. Baetz, K. M. Regula, K. Ens, J. Shaw, S. Kothari, N. Yurkova, and L. A. Kirshenbaum (2005)
Circulation 112, 3777-3785
   Abstract »    Full Text »    PDF »
The Nuclear Transcription Factor {kappa}B/bcl-2 Pathway Correlates with Pathologic Complete Response to Doxorubicin-Based Neoadjuvant Chemotherapy in Human Breast Cancer.
T. A. Buchholz, A. K. Garg, N. Chakravarti, B. B. Aggarwal, F. J. Esteva, H. M. Kuerer, S. E. Singletary, G. N. Hortobagyi, L. Pusztai, M. Cristofanilli, et al. (2005)
Clin. Cancer Res. 11, 8398-8402
   Abstract »    Full Text »    PDF »
NF-{kappa}B Activation in Human Dental Pulp Stem Cells by TNF and LPS.
J. Chang, C. Zhang, N. Tani-Ishii, S. Shi, and C.-Y. Wang (2005)
J. Dent. Res. 84, 994-998
   Abstract »    Full Text »    PDF »
N-(4-Hydroxyphenyl)Retinamide Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis through Down-regulation of I{kappa}B{alpha} Kinase and Nuclear Factor-{kappa}B-Regulated Gene Products.
S. Shishodia, A. M. Gutierrez, R. Lotan, and B. B. Aggarwal (2005)
Cancer Res. 65, 9555-9565
   Abstract »    Full Text »    PDF »
Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-{kappa}B Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice.
B. B. Aggarwal, S. Shishodia, Y. Takada, S. Banerjee, R. A. Newman, C. E. Bueso-Ramos, and J. E. Price (2005)
Clin. Cancer Res. 11, 7490-7498
   Abstract »    Full Text »    PDF »
Interferon Induces NF-{kappa}B-inducing Kinase/Tumor Necrosis Factor Receptor-associated Factor-dependent NF-{kappa}B Activation to Promote Cell Survival.
C. H. Yang, A. Murti, and L. M. Pfeffer (2005)
J. Biol. Chem. 280, 31530-31536
   Abstract »    Full Text »    PDF »
LNFPIII/LeX-Stimulated Macrophages Activate Natural Killer Cells via CD40-CD40L Interaction.
O. Atochina and D. Harn (2005)
Clin. Vaccine Immunol. 12, 1041-1049
   Abstract »    Full Text »    PDF »
Phase I Trial of Bortezomib and Carboplatin in Recurrent Ovarian or Primary Peritoneal Cancer.
C. Aghajanian, D.S. Dizon, P. Sabbatini, J.J. Raizer, J. Dupont, and D.R. Spriggs (2005)
J. Clin. Oncol. 23, 5943-5949
   Abstract »    Full Text »    PDF »
Inhibition of Macrophage Nuclear Factor-{kappa}B Leads to a Dominant Anti-Inflammatory Phenotype that Attenuates Glomerular Inflammation in Vivo.
H. M. Wilson, S. Chettibi, C. Jobin, D. Walbaum, A. J. Rees, and D. C. Kluth (2005)
Am. J. Pathol. 167, 27-37
   Abstract »    Full Text »    PDF »
Tobacco components stimulate Akt-dependent proliferation and NF{kappa}B-dependent survival in lung cancer cells.
J. Tsurutani, S.S. Castillo, J. Brognard, C. A. Granville, C. Zhang, J. J. Gills, J. Sayyah, and P. A. Dennis (2005)
Carcinogenesis 26, 1182-1195
   Abstract »    Full Text »    PDF »
Bcl-2 Acts in a Proangiogenic Signaling Pathway through Nuclear Factor-{kappa}B and CXC Chemokines.
E. Karl, K. Warner, B. Zeitlin, T. Kaneko, L. Wurtzel, T. Jin, J. Chang, S. Wang, C.-Y. Wang, R. M. Strieter, et al. (2005)
Cancer Res. 65, 5063-5069
   Abstract »    Full Text »    PDF »
Inhibition of MAPK and NF-{kappa}B Pathways Is Necessary for Rapid Apoptosis in Macrophages Infected with Yersinia.
Y. Zhang, A. T. Ting, K. B. Marcu, and J. B. Bliska (2005)
J. Immunol. 174, 7939-7949
   Abstract »    Full Text »    PDF »
Suppression of Calcium Release from Inositol 1,4,5-Trisphosphate-sensitive Stores Mediates the Anti-apoptotic Function of Nuclear Factor-{kappa}B.
S. Camandola, R. G. Cutler, D. S. Gary, O. Milhavet, and M. P. Mattson (2005)
J. Biol. Chem. 280, 22287-22296
   Abstract »    Full Text »    PDF »
Apoptosis Induction by a Novel Retinoid-Related Molecule Requires Nuclear Factor-{kappa}B Activation.
L. Farhana, M. I. Dawson, and J. A. Fontana (2005)
Cancer Res. 65, 4909-4917
   Abstract »    Full Text »    PDF »
Enhanced G2-M Arrest by Nuclear Factor-{kappa}B-Dependent p21waf1/cip1 Induction.
S. M. Wuerzberger-Davis, P.-Y. Chang, C. Berchtold, and S. Miyamoto (2005)
Mol. Cancer Res. 3, 345-353
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B Induced by Doxorubicin Is Deficient in Phosphorylation and Acetylation and Represses Nuclear Factor-{kappa}B-Dependent Transcription in Cancer Cells.
W. C. Ho, K. M. Dickson, and P. A. Barker (2005)
Cancer Res. 65, 4273-4281
   Abstract »    Full Text »    PDF »
1'-Acetoxychavicol Acetate Is a Novel Nuclear Factor {kappa}B Inhibitor with Significant Activity against Multiple Myeloma In vitro and In vivo.
K. Ito, T. Nakazato, M. J. Xian, T. Yamada, N. Hozumi, A. Murakami, H. Ohigashi, Y. Ikeda, and M. Kizaki (2005)
Cancer Res. 65, 4417-4424
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Reduces Brain Tumor Growth by Enhancing Macrophage Recruitment and Microcyst Formation.
J. Villeneuve, P. Tremblay, and L. Vallieres (2005)
Cancer Res. 65, 3928-3936
   Abstract »    Full Text »    PDF »
Function of Polo-like Kinase 3 in NF-{kappa}B-mediated Proapoptotic Response.
Z. Li, J. Niu, T. Uwagawa, B. Peng, and P. J. Chiao (2005)
J. Biol. Chem. 280, 16843-16850
   Abstract »    Full Text »    PDF »
NF{kappa}B-dependent Down-regulation of Tumor Necrosis Factor Receptor-associated Proteins Contributes to Interleukin-1-mediated Enhancement of Ultraviolet B-induced Apoptosis.
B. Poppelmann, K. Klimmek, E. Strozyk, R. Voss, T. Schwarz, and D. Kulms (2005)
J. Biol. Chem. 280, 15635-15643
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B-Dependent Mechanisms in Breast Cancer Cells Regulate Tumor Burden and Osteolysis in Bone.
A. H. Gordon, R. J. O'Keefe, E. M. Schwarz, R. N. Rosier, and J. E. Puzas (2005)
Cancer Res. 65, 3209-3217
   Abstract »    Full Text »    PDF »
Role for the Nuclear Factor {kappa}B Pathway in Transforming Growth Factor-{beta}1 Production in Idiopathic Myelofibrosis: Possible Relationship with FK506 Binding Protein 51 Overexpression.
E. Komura, C. Tonetti, V. Penard-Lacronique, H. Chagraoui, C. Lacout, J. P. LeCouedic, P. Rameau, N. Debili, W. Vainchenker, and S. Giraudier (2005)
Cancer Res. 65, 3281-3289
   Abstract »    Full Text »    PDF »
Serum Deprivation Induces Apoptotic Cell Death of Transformed Rat Retinal Ganglion Cells via Mitochondrial Signaling Pathways.
I. Charles, A. Khalyfa, D. M. Kumar, R. R. Krishnamoorthy, R. S. Roque, N. Cooper, and N. Agarwal (2005)
Invest. Ophthalmol. Vis. Sci. 46, 1330-1338
   Abstract »    Full Text »    PDF »
FOXO1 Functions as a Master Switch That Regulates Gene Expression Necessary for Tumor Necrosis Factor-induced Fibroblast Apoptosis.
M. Alikhani, Z. Alikhani, and D. T. Graves (2005)
J. Biol. Chem. 280, 12096-12102
   Abstract »    Full Text »    PDF »
Co-activation of ERK, NF-{kappa}B, and GADD45{beta} in Response to Ionizing Radiation.
T. Wang, Y.-C. Hu, S. Dong, M. Fan, D. Tamae, M. Ozeki, Q. Gao, D. Gius, and J. J. Li (2005)
J. Biol. Chem. 280, 12593-12601
   Abstract »    Full Text »    PDF »
Increased Expression of the E3-Ubiquitin Ligase Receptor Subunit {beta}TRCP1 Relates to Constitutive Nuclear Factor-{kappa}B Activation and Chemoresistance in Pancreatic Carcinoma Cells.
S. Muerkoster, A. Arlt, B. Sipos, M. Witt, M. Grossmann, G. Kloppel, H. Kalthoff, U. R. Folsch, and H. Schafer (2005)
Cancer Res. 65, 1316-1324
   Abstract »    Full Text »    PDF »
NF-{kappa}B Activation Is Not Required for Chlamydia trachomatis Inhibition of Host Epithelial Cell Apoptosis.
Y. Xiao, Y. Zhong, H. Su, Z. Zhou, P. Chiao, and G. Zhong (2005)
J. Immunol. 174, 1701-1708
   Abstract »    Full Text »    PDF »
Antisense Suppression of the Chloride Intracellular Channel Family Induces Apoptosis, Enhances Tumor Necrosis Factor {alpha}-Induced Apoptosis, and Inhibits Tumor Growth.
K. S. Suh, M. Mutoh, M. Gerdes, J. M. Crutchley, T. Mutoh, L. E. Edwards, R. A. Dumont, P. Sodha, C. Cheng, A. Glick,, et al. (2005)
Cancer Res. 65, 562-571
   Abstract »    Full Text »    PDF »
Targeting NF-{kappa}B activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.
C. Frelin, V. Imbert, E. Griessinger, A.-C. Peyron, N. Rochet, P. Philip, C. Dageville, A. Sirvent, M. Hummelsberger, E. Berard, et al. (2005)
Blood 105, 804-811
   Abstract »    Full Text »    PDF »
The Ubiquitin Proteasome Pathway from Bench to Bedside.
R. Z. Orlowski (2005)
Hematology 2005, 220-225
   Abstract »    Full Text »    PDF »
TNF-{alpha} induces proliferation or apoptosis in human saphenous vein smooth muscle cells depending on phenotype.
Z. Wang, P. J. Rao, M. R. Castresana, and W. H. Newman (2005)
Am J Physiol Heart Circ Physiol 288, H293-H301
   Abstract »    Full Text »    PDF »
Efficient Replication by Herpes Simplex Virus Type 1 Involves Activation of the I{kappa}B Kinase-I{kappa}B-p65 Pathway.
D. Gregory, D. Hargett, D. Holmes, E. Money, and S. L. Bachenheimer (2004)
J. Virol. 78, 13582-13590
   Abstract »    Full Text »    PDF »
Insulin Regulates Cleavage of Procaspase-9 via Binding of X Chromosome-Linked Inhibitor of Apoptosis Protein in HT-29 Cells.
J.-E. Kim and S. R. Tannenbaum (2004)
Cancer Res. 64, 9070-9075