Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 November 1996:
Vol. 274. no. 5288, pp. 782 - 784
DOI: 10.1126/science.274.5288.782
Prev | Table of Contents | Next

Reports

An Essential Role for NF-kappa B in Preventing TNF-alpha -Induced Cell Death

Amer A. Beg * and David Baltimore dagger

Studies on mice deficient in nuclear factor kappa B (NF-kappa B) subunits have shown that this transcription factor is important for lymphocyte responses to antigens and cytokine-inducible gene expression. In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-alpha (TNF-alpha )-dependent genes. Treatment of RelA-deficient (RelA-/-) mouse fibroblasts and macrophages with TNF-alpha resulted in a significant reduction in viability, whereas RelA+/+ cells were unaffected. Cytotoxicity to both cell types was mediated by TNF receptor 1. Reintroduction of RelA into RelA-/- fibroblasts resulted in enhanced survival, demonstrating that the presence of RelA is required for protection from TNF-alpha . These results have implications for the treatment of inflammatory and proliferative diseases.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
*   Present address: Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

dagger    To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genomic expression profiling of peripheral blood leukocytes of pigs infected with highly virulent classical swine fever virus strain Shimen.
Z. Shi, J. Sun, H. Guo, and C. Tu (2009)
J. Gen. Virol. 90, 1670-1680
   Abstract »    Full Text »    PDF »
Combination Effect between Bortezomib and Tumor Necrosis Factor {alpha} on Gefitinib-resistant Non-small Cell Lung Cancer Cell Lines.
S. KUSUMOTO, T. SUGIYAMA, K. ANDO, T. HOSAKA, H. ISHIDA, T. SHIRAI, T. YAMAOKA, K. OKUDA, T. HIROSE, T. OHNISHI, et al. (2009)
Anticancer Res 29, 2315-2322
   Abstract »    Full Text »    PDF »
Hepatitis B Virus X Protein Modulates Apoptosis in Primary Rat Hepatocytes by Regulating both NF-{kappa}B and the Mitochondrial Permeability Transition Pore.
A. J. Clippinger, T. L. Gearhart, and M. J. Bouchard (2009)
J. Virol. 83, 4718-4731
   Abstract »    Full Text »    PDF »
N-Acetyl Cysteine Mediates Protection from 2-Hydroxyethyl Methacrylate Induced Apoptosis via Nuclear Factor Kappa B-Dependent and Independent Pathways: Potential Involvement of JNK.
A. Paranjpe, N. A. Cacalano, W. R. Hume, and A. Jewett (2009)
Toxicol. Sci. 108, 356-366
   Abstract »    Full Text »    PDF »
Huntingtin promotes cell survival by preventing Pak2 cleavage.
S. Luo and D. C. Rubinsztein (2009)
J. Cell Sci. 122, 875-885
   Abstract »    Full Text »    PDF »
Psoralidin, an Herbal Molecule, Inhibits Phosphatidylinositol 3-Kinase-Mediated Akt Signaling in Androgen-Independent Prostate Cancer Cells.
R. Kumar, S. Srinivasan, S. Koduru, P. Pahari, J. Rohr, N. Kyprianou, and C. Damodaran (2009)
Cancer Prevention Research 2, 234-243
   Abstract »    Full Text »    PDF »
Sensitization by 5-Azacytidine toward Death Receptor-Induced Hepatic Apoptosis.
T. Weiland, M. Weiller, G. Kunstle, and A. Wendel (2009)
J. Pharmacol. Exp. Ther. 328, 107-115
   Abstract »    Full Text »    PDF »
The Novel Nuclear Factor-{kappa}B Inhibitor LC-1 Is Equipotent in Poor Prognostic Subsets of Chronic Lymphocytic Leukemia and Shows Strong Synergy with Fludarabine.
S. Hewamana, T. T. Lin, C. Jenkins, A. K. Burnett, C. T. Jordan, C. Fegan, P. Brennan, C. Rowntree, and C. Pepper (2008)
Clin. Cancer Res. 14, 8102-8111
   Abstract »    Full Text »    PDF »
I{kappa}B{alpha} Kinase Inhibitor IKI-1 Conferred Tumor Necrosis Factor {alpha} Sensitivity to Pancreatic Cancer Cells and a Xenograft Tumor Model.
Y. Zhang, M. Gavriil, J. Lucas, S. Mandiyan, M. Follettie, V. Diesl, F.-W. Sum, D. Powell, S. Haney, R. Abraham, et al. (2008)
Cancer Res. 68, 9519-9524
   Abstract »    Full Text »    PDF »
NF-{kappa}B Modulates Sensitivity to Apoptosis, Proinflammatory and Migratory Potential in Short- versus Long-Term Cultured Human {gamma}{delta} Lymphocytes.
M. Ferrarini, F. Delfanti, M. Gianolini, C. Rizzi, M. Alfano, A. Lazzarin, and P. Biswas (2008)
J. Immunol. 181, 5857-5864
   Abstract »    Full Text »    PDF »
The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts.
J. Yang, M. F. Siqueira, Y. Behl, M. Alikhani, and D. T. Graves (2008)
FASEB J 22, 3956-3967
   Abstract »    Full Text »    PDF »
Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins.
T. Kohno, T. Daa, H. Otani, I. Shimokawa, S. Yokoyama, and T. Matsuyama (2008)
Genes Cells 13, 1061-1073
   Abstract »    Full Text »    PDF »
The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies.
L. Paoluzzi, M. Gonen, G. Bhagat, R. R. Furman, J. R. Gardner, L. Scotto, V. D. Gueorguiev, M. L. Heaney, K. Manova, and O. A. O'Connor (2008)
Blood 112, 2906-2916
   Abstract »    Full Text »    PDF »
The Translational Research Working Group Developmental Pathway for Anticancer Agents (Drugs or Biologics).
R. L. Schilsky, G. Gordon, T. M. Gilmer, S. A. Courtneidge, L. M. Matrisian, O. Grad, W. G. Nelson, and on behalf of the Translational Research Working Gr (2008)
Clin. Cancer Res. 14, 5685-5691
   Abstract »    Full Text »    PDF »
Regulation of apoptosis by XIAP ubiquitin-ligase activity.
A. J. Schile, M. Garcia-Fernandez, and H. Steller (2008)
Genes & Dev. 22, 2256-2266
   Abstract »    Full Text »    PDF »
CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-{kappa}B Activation and Up-Regulation of c-FLIP and Bcl-xL.
M. Travert, P. Ame-Thomas, C. Pangault, A. Morizot, O. Micheau, G. Semana, T. Lamy, T. Fest, K. Tarte, and T. Guillaudeux (2008)
J. Immunol. 181, 1001-1011
   Abstract »    Full Text »    PDF »
Modulation of Gene Expression via Disruption of NF-{kappa}B Signaling by a Bacterial Small Molecule.
V. V. Kravchenko, G. F. Kaufmann, J. C. Mathison, D. A. Scott, A. Z. Katz, D. C. Grauer, M. Lehmann, M. M. Meijler, K. D. Janda, and R. J. Ulevitch (2008)
Science 321, 259-263
   Abstract »    Full Text »    PDF »
Bortezomib: A novel chemotherapeutic agent for hematologic malignancies.
K. N. Utecht and J. Kolesar (2008)
Am. J. Health Syst. Pharm. 65, 1221-1231
   Abstract »    Full Text »    PDF »
The Nuclear Factor-{kappa}B and p53 Pathways Function Independently in Primary Cells and Transformed Fibroblasts Responding to Genotoxic Damage.
D. Nesic, R. Grumont, and S. Gerondakis (2008)
Mol. Cancer Res. 6, 1193-1203
   Abstract »    Full Text »    PDF »
Selection and characterization of anti-NF-{kappa}B p65 RNA aptamers.
S. E. Wurster and L. J. Maher III (2008)
RNA 14, 1037-1047
   Abstract »    Full Text »    PDF »
A Distinctive Physiological Role for I{kappa}B{beta} in the Propagation of Mitochondrial Respiratory Stress Signaling.
G. Biswas, W. Tang, N. Sondheimer, M. Guha, S. Bansal, and N. G. Avadhani (2008)
J. Biol. Chem. 283, 12586-12594
   Abstract »    Full Text »    PDF »
Post-ischaemic neovascularization and inflammation.
J.-S. Silvestre, Z. Mallat, A. Tedgui, and B. I. Levy (2008)
Cardiovasc Res 78, 242-249
   Abstract »    Full Text »    PDF »
HO-1 underlies resistance of AML cells to TNF-induced apoptosis.
S. A. Rushworth and D. J. MacEwan (2008)
Blood 111, 3793-3801
   Abstract »    Full Text »    PDF »
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65.
C. Buerki, K. M. Rothgiesser, T. Valovka, H. R. Owen, H. Rehrauer, M. Fey, W. S. Lane, and M. O. Hottiger (2008)
Nucleic Acids Res. 36, 1665-1680
   Abstract »    Full Text »    PDF »
FOXO3a Turns the Tumor Necrosis Factor Receptor Signaling Towards Apoptosis Through Reciprocal Regulation of c-Jun N-Terminal Kinase and NF-{kappa}B.
H.-Y. Lee, S.-W. Youn, J.-Y. Kim, K.-W. Park, C.-I. Hwang, W.-Y. Park, B.-H. Oh, Y.-B. Park, K. Walsh, J.-S. Seo, et al. (2008)
Arterioscler. Thromb. Vasc. Biol. 28, 112-120
   Abstract »    Full Text »    PDF »
Enhancement of NF-{kappa}B Activation in Lymphocytes Prevents T Cell Apoptosis and Improves Survival in Murine Sepsis.
H. V. Groesdonk, F. Wagner, B. Hoffarth, M. Georgieff, and U. Senftleben (2007)
J. Immunol. 179, 8083-8089
   Abstract »    Full Text »    PDF »
Effects of Organ Culture and Optisol-GS Storage on Structural Integrity, Phenotypes, and Apoptosis in Cultured Corneal Epithelium.
S. Raeder, T. P. Utheim, O. A. Utheim, B. Nicolaissen, B. Roald, Y. Cai, K. Haug, A. Kvalheim, E. B. Messelt, L. Drolsum, et al. (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5484-5493
   Abstract »    Full Text »    PDF »
Degradation of Nuclear Factor Kappa B during Foot-and-Mouth Disease Virus Infection.
T. de los Santos, F. Diaz-San Segundo, and M. J. Grubman (2007)
J. Virol. 81, 12803-12815
   Abstract »    Full Text »    PDF »
TNF Pretreatment Interferes with Mitochondrial Apoptosis in the Mouse Liver by A20-Mediated Down-Regulation of Bax.
G. Sass, N. D. Shembade, F. Haimerl, N. Lamoureux, S. Hashemolhosseini, A. Tannapfel, and G. Tiegs (2007)
J. Immunol. 179, 7042-7049
   Abstract »    Full Text »    PDF »
Nuclear Translocation of NF-{kappa}B Precedes Apoptotic Poly(ADP-ribose) Polymerase Cleavage during Productive HSV-1 Replication in Corneal Epithelial Cells.
M. L. Goodkin, S. Epstein, P. A. Asbell, and J. A. Blaho (2007)
Invest. Ophthalmol. Vis. Sci. 48, 4980-4988
   Abstract »    Full Text »    PDF »
Pivotal Advance: Macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells.
D. Cui, E. Thorp, Y. Li, N. Wang, L. Yvan-Charvet, A. R. Tall, and I. Tabas (2007)
J. Leukoc. Biol. 82, 1040-1050
   Abstract »    Full Text »    PDF »
The {alpha}1beta1 Integrin and TNF Receptor II Protect Airway CD8+ Effector T Cells from Apoptosis during Influenza Infection.
M. V. Richter and D. J. Topham (2007)
J. Immunol. 179, 5054-5063
   Abstract »    Full Text »    PDF »
Blockade of Tumor Necrosis Factor-induced Bid Cleavage by Caspase-resistant Rb.
X. Huang, A. Masselli, S. M. Frisch, I. C. Hunton, Y. Jiang, and J. Y. J. Wang (2007)
J. Biol. Chem. 282, 29401-29413
   Abstract »    Full Text »    PDF »
Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.
A. White, D. Carragher, S. Parnell, A. Msaki, N. Perkins, P. Lane, E. Jenkinson, G. Anderson, and J. H. Caamano (2007)
Blood 110, 1950-1959
   Abstract »    Full Text »    PDF »
Cardiac expression of adenine nucleotide translocase-1 in transgenic mice overexpressing bovine GH.
F. Bogazzi, F. Raggi, F. Ultimieri, D. Russo, A. Manariti, A. D'Alessio, P. Viacava, G. Fanelli, M. Gasperi, L. Bartalena, et al. (2007)
J. Endocrinol. 194, 521-527
   Abstract »    Full Text »    PDF »
NFBD1/MDC1 Associates with p53 and Regulates Its Function at the Crossroad between Cell Survival and Death in Response to DNA Damage.
M. Nakanishi, T. Ozaki, H. Yamamoto, T. Hanamoto, H. Kikuchi, K. Furuya, M. Asaka, D. Delia, and A. Nakagawara (2007)
J. Biol. Chem. 282, 22993-23004
   Abstract »    Full Text »    PDF »
The Importance of Bcl-xL in the Survival of Human RPE Cells.
N. Zhang, J. J. Peairs, P. Yang, J. Tyrrell, J. Roberts, R. Kole, and G. J. Jaffe (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3846-3853
   Abstract »    Full Text »    PDF »
Application of the nuclear factor-{kappa}B inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study.
K. Nasu, M. Nishida, T. Ueda, A. Yuge, N. Takai, and H. Narahara (2007)
Am J Physiol Endocrinol Metab 293, E16-E23
   Abstract »    Full Text »    PDF »
Stabilization of p73 by Nuclear I{kappa}B Kinase-{alpha} Mediates Cisplatin-induced Apoptosis.
K. Furuya, T. Ozaki, T. Hanamoto, M. Hosoda, S. Hayashi, P. A. Barker, K. Takano, M. Matsumoto, and A. Nakagawara (2007)
J. Biol. Chem. 282, 18365-18378
   Abstract »    Full Text »    PDF »
A Parallel Dose-Escalation Study of Weekly and Twice-Weekly Bortezomib in Combination with Gemcitabine and Cisplatin in the First-Line Treatment of Patients with Advanced Solid Tumors.
J. Voortman, E. F. Smit, R. Honeywell, B. C. Kuenen, G. J. Peters, H. van de Velde, and G. Giaccone (2007)
Clin. Cancer Res. 13, 3642-3651
   Abstract »    Full Text »    PDF »
An Essential Role for TNF in Modulating Thresholds for Survival, Activation, and Tolerance of CD8+ T Cells.
I. Chatzidakis, G. Fousteri, D. Tsoukatou, G. Kollias, and C. Mamalaki (2007)
J. Immunol. 178, 6735-6745
   Abstract »    Full Text »    PDF »
Curcumin [1,7-Bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] Sensitizes Human Prostate Cancer Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand/Apo2L-Induced Apoptosis by Suppressing Nuclear Factor-{kappa}B via Inhibition of the Prosurvival Akt Signaling Pathway.
D. Deeb, H. Jiang, X. Gao, S. Al-Holou, A. L. Danyluk, S. A. Dulchavsky, and S. C. Gautam (2007)
J. Pharmacol. Exp. Ther. 321, 616-625
   Abstract »    Full Text »    PDF »
Transgenic Expression of A20 Prevents Cardiac Cell Death and Myocardial Dysfunction After Myocardial Infarction.
J. Shaw, I. A. Eydelnant, and L. A. Kirshenbaum (2007)
Circulation 115, 1827-1829
   Full Text »    PDF »
Focal adhesion kinase mediates cell survival via NF-{kappa}B and ERK signaling pathways.
D. Huang, M. Khoe, M. Befekadu, S. Chung, Y. Takata, D. Ilic, and M. Bryer-Ash (2007)
Am J Physiol Cell Physiol 292, C1339-C1352
   Abstract »    Full Text »    PDF »
Delayed Cell Cycle Progression and Apoptosis Induced by Hemicellulase-Treated Agaricus blazei.
M. Kawamura and H. Kasai (2007)
Evid. Based Complement. Altern. Med. 4, 83-94
   Abstract »    Full Text »    PDF »
Simultaneous Induction of Apoptotic and Survival Signaling Pathways in Macrophage-Like THP-1 Cells by Shiga Toxin 1.
S.-Y. Lee, R. P. Cherla, and V. L. Tesh (2007)
Infect. Immun. 75, 1291-1302
   Abstract »    Full Text »    PDF »
TNF Receptor-Associated Factor 2-Dependent Canonical Pathway Is Crucial for the Development of Peyer's Patches.
J.-H. Piao, H. Yoshida, W.-C. Yeh, T. Doi, X. Xue, H. Yagita, K. Okumura, and H. Nakano (2007)
J. Immunol. 178, 2272-2277
   Abstract »    Full Text »    PDF »
NF-{kappa}B prevents beta cell death and autoimmune diabetes in NOD mice.
S. Kim, I. Millet, H. S. Kim, J. Y. Kim, M. S. Han, M.-K. Lee, K.-W. Kim, R. S. Sherwin, M. Karin, and M.-S. Lee (2007)
PNAS 104, 1913-1918
   Abstract »    Full Text »    PDF »
Bid-Independent Mitochondrial Activation in Tumor Necrosis Factor Alpha-Induced Apoptosis and Liver Injury.
X. Chen, W.-X. Ding, H.-M. Ni, W. Gao, Y.-H. Shi, A. A. Gambotto, J. Fan, A. A. Beg, and X.-M. Yin (2007)
Mol. Cell. Biol. 27, 541-553
   Abstract »    Full Text »    PDF »
Tumor-Induced Oxidative Stress Perturbs Nuclear Factor-{kappa}B Activity-Augmenting Tumor Necrosis Factor-{alpha}-Mediated T-Cell Death: Protection by Curcumin.
S. Bhattacharyya, D. Mandal, G. S. Sen, S. Pal, S. Banerjee, L. Lahiry, J. H. Finke, C. S. Tannenbaum, T. Das, and G. Sa (2007)
Cancer Res. 67, 362-370
   Abstract »    Full Text »    PDF »
Viral protease cleavage of inhibitor of {kappa}B{alpha} triggers host cell apoptosis.
C. Zaragoza, M. Saura, E. Y. Padalko, E. Lopez-Rivera, T. R. Lizarbe, S. Lamas, and C. J. Lowenstein (2006)
PNAS 103, 19051-19056
   Abstract »    Full Text »    PDF »
Transcriptional Silencing of the Death Gene BNIP3 by Cooperative Action of NF-{kappa}B and Histone Deacetylase 1 in Ventricular Myocytes.
J. Shaw, T. Zhang, M. Rzeszutek, N. Yurkova, D. Baetz, J. R. Davie, and L. A. Kirshenbaum (2006)
Circ. Res. 99, 1347-1354
   Abstract »    Full Text »    PDF »
ERK5 Activates NF-{kappa}B in Leukemic T Cells and Is Essential for Their Growth In Vivo.
J. Garaude, S. Cherni, S. Kaminski, E. Delepine, C. Chable-Bessia, M. Benkirane, J. Borges, A. Pandiella, M. A. Iniguez, M. Fresno, et al. (2006)
J. Immunol. 177, 7607-7617
   Abstract »    Full Text »    PDF »
Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.
T. Kinoshita, C. Kondoh, M. Hasegawa, R. Imamura, and T. Suda (2006)
Int. Immunol. 18, 1701-1706
   Abstract »    Full Text »    PDF »
Wogonin sensitizes resistant malignant cells to TNF{alpha}- and TRAIL-induced apoptosis.
S. C. Fas, S. Baumann, J. Y. Zhu, M. Giaisi, M. K. Treiber, U. Mahlknecht, P. H. Krammer, and M. Li-Weber (2006)
Blood 108, 3700-3706
   Abstract »    Full Text »    PDF »
Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation.
J. Iqbal, L. Sun, T. R. Kumar, H. C. Blair, and M. Zaidi (2006)
PNAS 103, 14925-14930
   Abstract »    Full Text »    PDF »
Escherichia coli Prevents Phagocytosis-Induced Death of Macrophages via Classical NF-{kappa}B Signaling, a Link to T-Cell Activation..
H. V. Groesdonk, S. Schlottmann, F. Richter, M. Georgieff, and U. Senftleben (2006)
Infect. Immun. 74, 5989-6000
   Abstract »    Full Text »    PDF »
Constitutively Activated Nuclear Factor-{kappa}B, but not Induced NF-{kappa}B, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells.
S. J. Braeuer, C. Buneker, A. Mohr, and R. M. Zwacka (2006)
Mol. Cancer Res. 4, 715-728
   Abstract »    Full Text »    PDF »
Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis.
K. Miller-Jensen, K. A. Janes, Y.-L. Wong, L. G. Griffith, and D. A. Lauffenburger (2006)
J. Cell Sci. 119, 3788-3798
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B Regulates {beta}-Cell Death: A Critical Role for A20 in {beta}-Cell Protection.
D. Liuwantara, M. Elliot, M. W. Smith, A. O. Yam, S. N. Walters, E. Marino, A. McShea, and S. T. Grey (2006)
Diabetes 55, 2491-2501
   Abstract »    Full Text »    PDF »
The Antineoplastic Agent Bryostatin-1 Differentially Regulates IFN-{gamma} Receptor Subunits in Monocytic Cells: Transcriptional and Posttranscriptional Control of IFN-{gamma}R2.
C. S. Garcia, R. E. Curiel, J. M. Mwatibo, S. Pestka, H. Li, and I. Espinoza-Delgado (2006)
J. Immunol. 177, 2707-2716
   Abstract »    Full Text »    PDF »
Environmental Tobacco Smoke Suppresses Nuclear Factor-{kappa}B Signaling to Increase Apoptosis in Infant Monkey Lungs.
C.-Y. Zhong, Y. M. Zhou, J. P. Joad, and K. E. Pinkerton (2006)
Am. J. Respir. Crit. Care Med. 174, 428-436
   Abstract »    Full Text »    PDF »
Mechanism of Action of a Distal NF-{kappa}B-Dependent Enhancer.
B. Teferedegne, M. R. Green, Z. Guo, and J. M. Boss (2006)
Mol. Cell. Biol. 26, 5759-5770
   Abstract »    Full Text »    PDF »
Cytokine-Induced Proapoptotic Gene Expression in Insulin-Producing Cells Is Related to Rapid, Sustained, and Nonoscillatory Nuclear Factor-{kappa}B Activation.
F. Ortis, A. K. Cardozo, D. Crispim, J. Storling, T. Mandrup-Poulsen, and D. L. Eizirik (2006)
Mol. Endocrinol. 20, 1867-1879
   Abstract »    Full Text »    PDF »
Specific Recognition of Apoptotic Cells Reveals a Ubiquitous and Unconventional Innate Immunity.
M. Cvetanovic, J. E. Mitchell, V. Patel, B. S. Avner, Y. Su, P. T. van der Saag, P. L. Witte, S. Fiore, J. S. Levine, and D. S. Ucker (2006)
J. Biol. Chem. 281, 20055-20067
   Abstract »    Full Text »    PDF »
Distinct Domains for Anti- and Pro-apoptotic Activities of IEX-1.
L. Shen, J. Guo, C. Santos-Berrios, and M. X. Wu (2006)
J. Biol. Chem. 281, 15304-15311
   Abstract »    Full Text »    PDF »
Perforin and Fas induced by IFN{gamma} and TNF{alpha} mediate beta cell death by OT-I CTL.
M. D McKenzie, N. L Dudek, L. Mariana, M. M. Chong, J. A Trapani, T. W. Kay, and H. E Thomas (2006)
Int. Immunol. 18, 837-846
   Abstract »    Full Text »    PDF »
Mitochondrial Thioredoxin-2 Has a Key Role in Determining Tumor Necrosis Factor-{alpha}-Induced Reactive Oxygen Species Generation, NF-{kappa}B Activation, and Apoptosis.
J. M. Hansen, H. Zhang, and D. P. Jones (2006)
Toxicol. Sci. 91, 643-650
   Abstract »    Full Text »    PDF »
Protein Methyltransferase 2 Inhibits NF-{kappa}B Function and Promotes Apoptosis.
L. Ganesh, T. Yoshimoto, N. C. Moorthy, W. Akahata, M. Boehm, E. G. Nabel, and G. J. Nabel (2006)
Mol. Cell. Biol. 26, 3864-3874
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B Activated by Capacitative Ca2+ Entry Enhances Muscarinic Receptor-mediated Soluble Amyloid Precursor Protein (sAPP{alpha}) Release in SH-SY5Y Cells.
S. Choi, J. H. Kim, E.-J. Roh, M.-J. Ko, J.-E. Jung, and H.-J. Kim (2006)
J. Biol. Chem. 281, 12722-12728
   Abstract »    Full Text »    PDF »
NF{kappa}B Negatively Regulates Interferon-induced Gene Expression and Anti-influenza Activity.
L. Wei, M. R. Sandbulte, P. G. Thomas, R. J. Webby, R. Homayouni, and L. M. Pfeffer (2006)
J. Biol. Chem. 281, 11678-11684
   Abstract »    Full Text »    PDF »
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures.
R P Lisak, J A Benjamins, B Bealmear, B Yao, S Land, L Nedelkoska, and D Skundric (2006)
Multiple Sclerosis 12, 149-168
   Abstract »    PDF »
Inhibition of Hepatocarcinogenesis by the Deletion of the p50 Subunit of NF-{kappa}B in Mice Administered the Peroxisome Proliferator Wy-14,643.
H. P. Glauert, A. Eyigor, J. C. Tharappel, S. Cooper, E. Y. Lee, and B. T. Spear (2006)
Toxicol. Sci. 90, 331-336
   Abstract »    Full Text »    PDF »
Reduction of experimental necrotizing enterocolitis with anti-TNF-{alpha}.
M. D. Halpern, J. A. Clark, T. A. Saunders, S. M. Doelle, D. M. Hosseini, A. M. Stagner, and B. Dvorak (2006)
Am J Physiol Gastrointest Liver Physiol 290, G757-G764
   Abstract »    Full Text »    PDF »
TNF-{alpha} in Cancer Treatment: Molecular Insights, Antitumor Effects, and Clinical Utility..
R. van Horssen, T. L. M. ten Hagen, and A. M. M. Eggermont (2006)
Oncologist 11, 397-408
   Abstract »    Full Text »    PDF »
Antianoikis Effect of Nuclear Factor-{kappa}B through Up-regulated Expression of Osteoprotegerin, BCL-2, and IAP-1.
M. Toruner, M. Fernandez-Zapico, J. J. Sha, L. Pham, R. Urrutia, and L. J. Egan (2006)
J. Biol. Chem. 281, 8686-8696
   Abstract »    Full Text »    PDF »
Glucocorticoids enhance cytotoxicity of cisplatin via suppression of NF-{kappa}B activation in the glucocorticoid receptor-rich human cervical carcinoma cell line SiHa.
Y.-S. Lu, P.-Y. Yeh, S.-E. Chuang, M. Gao, M.-L. Kuo, and A.-L. Cheng (2006)
J. Endocrinol. 188, 311-319
   Abstract »    Full Text »    PDF »
A Splice Variant of Stress Response Gene ATF3 Counteracts NF-{kappa}B-dependent Anti-apoptosis through Inhibiting Recruitment of CREB-binding Protein/p300 Coactivator.
B. Hua, M. Tamamori-Adachi, Y. Luo, K. Tamura, M. Morioka, M. Fukuda, Y. Tanaka, and S. Kitajima (2006)
J. Biol. Chem. 281, 1620-1629
   Abstract »    Full Text »    PDF »
Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-{kappa}B Transactivation.
K. J. Campbell, J. M. Witty, S. Rocha, and N. D. Perkins (2006)
Cancer Res. 66, 929-935
   Abstract »    Full Text »    PDF »
PAK4 Functions in Tumor Necrosis Factor (TNF) {alpha}-induced Survival Pathways by Facilitating TRADD Binding to the TNF Receptor.
X. Li and A. Minden (2005)
J. Biol. Chem. 280, 41192-41200
   Abstract »    Full Text »    PDF »
Enhancement of Sensitivity to Tumor Necrosis Factor {alpha} in Non-Small Cell Lung Cancer Cells with Acquired Resistance to Gefitinib.
K. Ando, T. Ohmori, F. Inoue, T. Kadofuku, T. Hosaka, H. Ishida, T. Shirai, K. Okuda, T. Hirose, N. Horichi, et al. (2005)
Clin. Cancer Res. 11, 8872-8879
   Abstract »    Full Text »    PDF »
Nuclear Factor-{kappa}B-Mediated Cell Survival Involves Transcriptional Silencing of the Mitochondrial Death Gene BNIP3 in Ventricular Myocytes.
D. Baetz, K. M. Regula, K. Ens, J. Shaw, S. Kothari, N. Yurkova, and L. A. Kirshenbaum (2005)
Circulation 112, 3777-3785
   Abstract »    Full Text »    PDF »
NF-{kappa}B and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs).
D. M. B. Kerbauy, V. Lesnikov, N. Abbasi, S. Seal, B. Scott, and H. J. Deeg (2005)
Blood 106, 3917-3925
   Abstract »    Full Text »    PDF »
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
J.-H. Shim, C. Xiao, A. E. Paschal, S. T. Bailey, P. Rao, M. S. Hayden, K.-Y. Lee, C. Bussey, M. Steckel, N. Tanaka, et al. (2005)
Genes & Dev. 19, 2668-2681
   Abstract »    Full Text »    PDF »
Distinct Role of Calmodulin and Calmodulin-dependent Protein Kinase-II in Lipopolysaccharide and Tumor Necrosis Factor-{alpha}-mediated Suppression of Apoptosis and Antiapoptotic c-IAP2 Gene Expression in Human Monocytic Cells.
S. Mishra, J. P. Mishra, K. Gee, D. C. McManus, E. C. LaCasse, and A. Kumar (2005)
J. Biol. Chem. 280, 37536-37546
   Abstract »    Full Text »    PDF »
Protein turnover in cardiac cell growth and survival.
N. Hedhli, M. Pelat, and C. Depre (2005)
Cardiovasc Res 68, 186-196
   Abstract »    Full Text »    PDF »
Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity.
K. Sun, D. E. C. Wilkins, M. R. Anver, T. J. Sayers, A. Panoskaltsis-Mortari, B. R. Blazar, L. A. Welniak, and W. J. Murphy (2005)
Blood 106, 3293-3299
   Abstract »    Full Text »    PDF »
Epidermal growth factor activates nuclear factor-{kappa}B in human proximal tubule cells.
U. Haussler, G. von Wichert, R. M. Schmid, F. Keller, and G. Schneider (2005)
Am J Physiol Renal Physiol 289, F808-F815
   Abstract »    Full Text »    PDF »
Expression of an Uncleavable N-terminal RasGAP Fragment in Insulin-secreting Cells Increases Their Resistance toward Apoptotic Stimuli without Affecting Their Glucose-induced Insulin Secretion.
J.-Y. Yang, J. Walicki, A. Abderrahmani, M. Cornu, G. Waeber, B. Thorens, and C. Widmann (2005)
J. Biol. Chem. 280, 32835-32842
   Abstract »    Full Text »    PDF »
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.
S. Sanjabi, K. J. Williams, S. Saccani, L. Zhou, A. Hoffmann, G. Ghosh, S. Gerondakis, G. Natoli, and S. T. Smale (2005)
Genes & Dev. 19, 2138-2151
   Abstract »    Full Text »    PDF »
Interferon Induces NF-{kappa}B-inducing Kinase/Tumor Necrosis Factor Receptor-associated Factor-dependent NF-{kappa}B Activation to Promote Cell Survival.
C. H. Yang, A. Murti, and L. M. Pfeffer (2005)
J. Biol. Chem. 280, 31530-31536
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Receptor 2 (TNFR2) Signaling Is Negatively Regulated by a Novel, Carboxyl-terminal TNFR-associated Factor 2 (TRAF2)-binding Site.
A. P. Grech, S. Gardam, T. Chan, R. Quinn, R. Gonzales, A. Basten, and R. Brink (2005)
J. Biol. Chem. 280, 31572-31581
   Abstract »    Full Text »    PDF »
LNFPIII/LeX-Stimulated Macrophages Activate Natural Killer Cells via CD40-CD40L Interaction.
O. Atochina and D. Harn (2005)
Clin. Vaccine Immunol. 12, 1041-1049
   Abstract »    Full Text »    PDF »
Phase I Trial of Bortezomib and Carboplatin in Recurrent Ovarian or Primary Peritoneal Cancer.
C. Aghajanian, D.S. Dizon, P. Sabbatini, J.J. Raizer, J. Dupont, and D.R. Spriggs (2005)
J. Clin. Oncol. 23, 5943-5949
   Abstract »    Full Text »    PDF »
Intracellular Signal Transduction Pathway Proteins As Targets for Cancer Therapy.
A. A. Adjei and M. Hidalgo (2005)
J. Clin. Oncol. 23, 5386-5403
   Abstract »    Full Text »    PDF »
Retinal-Cell-Conditioned Medium Prevents TNF-{alpha}-Induced Apoptosis of Purified Ganglion Cells.
C. Fuchs, V. Forster, E. Balse, J.-A. Sahel, S. Picaud, and L.-H. Tessier (2005)
Invest. Ophthalmol. Vis. Sci. 46, 2983-2991
   Abstract »    Full Text »    PDF »
A Phase II Trial with Pharmacodynamic Endpoints of the Proteasome Inhibitor Bortezomib in Patients with Metastatic Colorectal Cancer.
H. Mackay, D. Hedley, P. Major, C. Townsley, M. Mackenzie, M. Vincent, P. Degendorfer, M.-S. Tsao, T. Nicklee, D. Birle, et al. (2005)
Clin. Cancer Res. 11, 5526-5533
   Abstract »    Full Text »    PDF »
Inhibition of astroglial nuclear factor {kappa}B reduces inflammation and improves functional recovery after spinal cord injury.
R. Brambilla, V. Bracchi-Ricard, W.-H. Hu, B. Frydel, A. Bramwell, S. Karmally, E. J. Green, and J. R. Bethea (2005)
J. Exp. Med. 202, 145-156
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)