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Science 25 October 1996:
Vol. 274. no. 5287, pp. 594 - 597
DOI: 10.1126/science.274.5287.594
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Reports

Presynaptic Calcium Current Modulation by a Metabotropic Glutamate Receptor

Tomoyuki Takahashi, * Ian D. Forsythe, Tetsuhiro Tsujimoto, Margaret Barnes-Davies, Kayoko Onodera

Metabotropic glutamate receptors (mGluRs) regulate transmitter release at mammalian central synapses. However, because of the difficulty of recording from mammalian presynaptic terminals, the mechanism underlying mGluR-mediated presynaptic inhibition is not known. Here, simultaneous recordings from a giant presynaptic terminal, the calyx of Held, and its postsynaptic target in the medial nucleus of the trapezoid body were obtained in rat brainstem slices. Agonists of mGluRs suppressed a high voltage-activated P/Q-type calcium conductance in the presynaptic terminal, thereby inhibiting transmitter release at this glutamatergic synapse. Because several forms of presynaptic modulation and plasticity are mediated by mGluRs, this identification of a target ion channel is a first step toward elucidation of their molecular mechanism.

T. Takahashi, T. Tsujimoto, K. Onodera, Department of Neurophysiology, Institute for Brain Research, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan.
I. D. Forsythe and M. Barnes-Davies, Ion Channel Group, Department of Cell Physiology and Pharmacology, University of Leicester, Post Office Box 138, Leicester LE1 9HN, UK.
*   To whom correspondence should be addressed. E-mail: ttakahas-tky{at}umin.u-tokyo.ac.jp

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Ca2+ Channel beta 3 Subunit Enhances Voltage-Dependent Relief of G-Protein Inhibition Induced by Muscarinic Receptor Activation and Gbeta gamma.
J. P. Roche and S. N. Treistman (1998)
J. Neurosci. 18, 4883-4890
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Anatomy and Physiology of Principal Cells of the Medial Nucleus of the Trapezoid Body (MNTB) of the Cat.
P. H. Smith, P. X. Joris, and T. C. T. Yin (1998)
J Neurophysiol 79, 3127-3142
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Developmental changes in calcium channel types mediating synaptic transmission in rat auditory brainstem.
S. Iwasaki and T. Takahashi (1998)
J. Physiol. 509, 419-423
   Abstract »    Full Text »    PDF »


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