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Science 18 October 1996:
Vol. 274. no. 5286, pp. 421 - 423
DOI: 10.1126/science.274.5286.421
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Reports

Resistance to Leishmania major Induced by Tolerance to a Single Antigen

Valérie Julia, Minoo Rassoulzadegan, Nicolas Glaichenhaus *

In mice, susceptibility to Leishmania major is associated with the early expansion of T helper 2 cells (TH2) cells, but nothing is known of the specificity of these cells. A previously identified antigen, Leishmania homolog of receptors for activated C kinase (LACK), was found to be the focus of this initial response. Mice made tolerant to LACK by the transgenic expression of the antigen in the thymus exhibited both a diminished TH2 response and a healing phenotype. Thus, T cells that are activated early and are reactive to a single antigen play a pivotal role in directing the immune response to the entire parasite.

V. Julia and N. Glaichenhaus, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 660 Route des Lucioles, 06560 Valbonne, France.
M. Rassoulzadegan, Unité INSERM 273, Faculté des Sciences, 06108 Nice Cedex 2, France.
*   To whom correspondence should be addressed. E-mail: GLAICHEN{at}naxos.unice.fr

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   Abstract »    PDF »
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S. Gurunathan, D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder (1997)
J. Exp. Med. 186, 1137-1147
   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »


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