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Science 11 October 1996:
Vol. 274. no. 5285, pp. 252 - 255
DOI: 10.1126/science.274.5285.252
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Reports

Visualization of Gene Expression in Living Adult Drosophila

Manuel Calleja, Eduardo Moreno, Soraya Pelaz, Ginés Morata *

To identify genes involved in the patterning of adult structures, Gal4-UAS (upstream activating site) technology was used to visualize patterns of gene expression directly in living flies. A large number of Gal4 insertion lines were generated and their expression patterns were studied. In addition to identifying several characterized developmental genes, the approach revealed previously unsuspected genetic subdivisions of the thorax, which may control the disposition of pattern elements. The boundary between two of these domains coincides with localized expression of the signaling molecule wingless.

Centro de Biología Molecular, Universidad Autónoma de Madrid, Consejo Superior de Investigaciónes Científicas, Madrid 28049, Spain.
*   To whom correspondence should be addressed. E-mail: gmorata{at}mvax.cbm.uam.es

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Function and regulation of homothorax in the wing imaginal disc of Drosophila.
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J Zeitlinger and D Bohmann (1999)
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Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development.
M Abu-Shaar and R. Mann (1998)
Development 125, 3821-3830
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C Rodriguez-Esteban, J. Schwabe, J. Pena, D. Rincon-Limas, J Magallon, J Botas, and J. Belmonte (1998)
Development 125, 3925-3934
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B Bello, D Resendez-Perez, and W. Gehring (1998)
Development 125, 2193-2202
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J. Duffy, D. Harrison, and N Perrimon (1998)
Development 125, 2263-2271
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B. Kehl, K. Cho, and K. Choi (1998)
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Y. Cubadda, P. Heitzler, R. P. Ray, M. Bourouis, P. Ramain, W. Gelbart, P. Simpson, and M. Haenlin (1997)
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M. Haenlin, Y. Cubadda, F. Blondeau, P. Heitzler, Y. Lutz, P. Simpson, and P. Ramain (1997)
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X S Hou, E S Goldstein, and N Perrimon (1997)
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Developmental parameters of cell death in the wing disc of Drosophila.
M. Milan, S. Campuzano, and A. Garcia-Bellido (1997)
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Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning.
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The Rac GTPase-activating Protein RotundRacGAP Interferes with Drac1 and Dcdc42 Signalling in Drosophila melanogaster.
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