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Science 4 October 1996:
Vol. 274. no. 5284, pp. 94 - 96
DOI: 10.1126/science.274.5284.94
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Reports

Phenotypic Analysis of Antigen-Specific T Lymphocytes

John D. Altman, Paul A. H. Moss, Philip J. R. Goulder, Dan H. Barouch, Michael G. McHeyzer-Williams, * John I. Bell, Andrew J. McMichael, Mark M. Davis dagger

Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and indirect. To address this problem, the peptide-major histocompatability complex (MHC) ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers. Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals. In general, tetramer binding correlated well with cytotoxicity assays. This approach should be useful in the analysis of T cells specific for infectious agents, tumors, and autoantigens.

J. D. Altman and M. G. McHeyzer-Williams, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5428, USA.
P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, J. I. Bell, A. J. McMichael, Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
M. M. Davis, The Howard Hughes Medical Institute, Department of Microbiology and Immunology, Beckman Center, Room B221, Stanford University, Stanford, CA 94305-5428, USA.
*   Present address: Department of Immunology, Duke University Medical Center, Durham, NC 27707, USA.

dagger    To whom correspondence should be addressed.

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P. Romero, A. Zippelius, I. Kurth, M. J. Pittet, C. Touvrey, E. M. Iancu, P. Corthesy, E. Devevre, D. E. Speiser, and N. Rufer (2007)
J. Immunol. 178, 4112-4119
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Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation.
J. Zhu, D. M. Koelle, J. Cao, J. Vazquez, M. L. Huang, F. Hladik, A. Wald, and L. Corey (2007)
J. Exp. Med. 204, 595-603
   Abstract »    Full Text »    PDF »
Analysis of TCR{alpha}beta Combinations used by Simian Immunodeficiency Virus-Specific CD8+ T Cells in Rhesus Monkeys: Implications for CTL Immunodominance.
A. Hasegawa, C. Moriya, H. Liu, W. A. Charini, H. C. Vinet, R. A. Subbramanian, P. Sen, N. L. Letvin, and M. J. Kuroda (2007)
J. Immunol. 178, 3409-3417
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IL-12 Controls Cytotoxicity of a Novel Subset of Self-Antigen-Specific Human CD28+ Cytolytic T Cells.
C. Barbey, P. Baumgaertner, E. Devevre, V. Rubio-Godoy, L. Derre, G. Bricard, P. Guillaume, I. F. Luescher, D. Lienard, J.-C. Cerottini, et al. (2007)
J. Immunol. 178, 3566-3574
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Facilitating matched pairing and expression of TCR chains introduced into human T cells.
J. Kuball, M. L. Dossett, M. Wolfl, W. Y. Ho, R.-H. Voss, C. Fowler, and P. D. Greenberg (2007)
Blood 109, 2331-2338
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Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells.
C. Petrovas, Y. M. Mueller, I. D. Dimitriou, S. R. Altork, A. Banerjee, P. Sklar, K. C. Mounzer, J. D. Altman, and P. D. Katsikis (2007)
Blood 109, 2505-2513
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Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection.
P. Agnellini, P. Wolint, M. Rehr, J. Cahenzli, U. Karrer, and A. Oxenius (2007)
PNAS 104, 4565-4570
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Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.
J. Back, A. Chalifour, L. Scarpellino, and W. Held (2007)
PNAS 104, 3978-3983
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Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients.
M. Raki, L.-E. Fallang, M. Brottveit, E. Bergseng, H. Quarsten, K. E. A. Lundin, and L. M. Sollid (2007)
PNAS 104, 2831-2836
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Quantitating the Magnitude of the Lymphocytic Choriomeningitis Virus-Specific CD8 T-Cell Response: It Is Even Bigger than We Thought.
D. Masopust, K. Murali-Krishna, and R. Ahmed (2007)
J. Virol. 81, 2002-2011
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Persistent Antigen Presentation after Acute Vesicular Stomatitis Virus Infection.
D. L. Turner, L. S. Cauley, K. M. Khanna, and L. Lefrancois (2007)
J. Virol. 81, 2039-2046
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Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis.
L. Scarpellino, F. Oeschger, P. Guillaume, J. D. Coudert, F. Levy, G. Leclercq, and W. Held (2007)
J. Immunol. 178, 1277-1284
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An In Vivo Cytotoxicity Threshold for Influenza A Virus-Specific Effector and Memory CD8+ T Cells.
J. Stambas, P. C. Doherty, and S. J. Turner (2007)
J. Immunol. 178, 1285-1292
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Identical beta Cell-Specific CD8+ T Cell Clonotypes Typically Reside in Both Peripheral Blood Lymphocyte and Pancreatic Islets.
C. P. Wong, R. Stevens, B. Long, L. Li, Y. Wang, M. A. Wallet, K. S. Goudy, J. A. Frelinger, and R. Tisch (2007)
J. Immunol. 178, 1388-1395
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Comparative Efficacy of Subtype AE Simian-Human Immunodeficiency Virus Priming and Boosting Vaccines in Pigtail Macaques.
R. De Rose, C. J. Batten, M. Z. Smith, C. S. Fernandez, V. Peut, S. Thomson, I. A. Ramshaw, B. E. H. Coupar, D. B. Boyle, V. Venturi, et al. (2007)
J. Virol. 81, 292-300
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Selective Survival of Naturally Occurring Human CD4+CD25+Foxp3+ Regulatory T Cells Cultured with Rapamycin.
L. Strauss, T. L. Whiteside, A. Knights, C. Bergmann, A. Knuth, and A. Zippelius (2007)
J. Immunol. 178, 320-329
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Functional HY-Specific CD8+ T Cells Are Found in a High Proportion of Women Following Pregnancy with a Male Fetus.
K. P. Piper, A. McLarnon, J. Arrazi, C. Horlock, J. Ainsworth, M. D. Kilby, W. L. Martin, and P. A. Moss (2007)
Biol Reprod 76, 96-101
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