Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Applied Biosystems SDS

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 October 1996:
Vol. 274. no. 5284, pp. 90 - 94
DOI: 10.1126/science.274.5284.90
Prev | Table of Contents | Next

Reports

A Cellular Homolog of Hepatitis Delta Antigen: Implications for Viral Replication and Evolution

Robert Brazas and Don Ganem *

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. However, viroid genomes contain no open reading frames, whereas HDV RNA encodes a single protein, hepatitis delta antigen (HDAg), which is required for viral replication. A cellular gene whose product interacts with HDAg has now been identified, and this interaction was found to affect viral genomic replication in intact cells. DNA sequence analysis revealed that this protein, termed delta-interacting protein A (DIPA), is a cellular homolog of HDAg. These observations demonstrate that a host gene product can modulate HDV replication and suggest that HDV may have evolved from a primitive viroidlike RNA through capture of a cellular transcript.

R. Brazas, Departments of Microbiology and Medicine, University of California, San Francisco, CA 94143, USA.
D. Ganem, Howard Hughes Medical Institute and Departments of Microbiology and Medicine, University of California, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ERK1/2-Mediated Phosphorylation of Small Hepatitis Delta Antigen at Serine 177 Enhances Hepatitis Delta Virus Antigenomic RNA Replication.
Y.-S. Chen, W.-H. Huang, S.-Y. Hong, Y.-G. Tsay, and P.-J. Chen (2008)
J. Virol. 82, 9345-9358
   Abstract »    Full Text »    PDF »
Transcription Factor YY1 and Its Associated Acetyltransferases CBP and p300 Interact with Hepatitis Delta Antigens and Modulate Hepatitis Delta Virus RNA Replication.
W.-H. Huang, R.-T. Mai, and Y.-H. Wu Lee (2008)
J. Virol. 82, 7313-7324
   Abstract »    Full Text »    PDF »
A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene..
K. Salehi-Ashtiani, A. Luptak, A. Litovchick, and J. W. Szostak (2006)
Science 313, 1788-1792
   Abstract »    Full Text »    PDF »
RNA Replication without RNA-Dependent RNA Polymerase: Surprises from Hepatitis Delta Virus.
M. M. C. Lai (2005)
J. Virol. 79, 7951-7958
   Full Text »    PDF »
Delta-interacting Protein A, a New Inhibitory Partner of CCAAT/Enhancer-binding Protein {beta}, Implicated in Adipocyte Differentiation.
O. Bezy, C. Elabd, O. Cochet, R. K. Petersen, K. Kristiansen, C. Dani, G. Ailhaud, and E.-Z. Amri (2005)
J. Biol. Chem. 280, 11432-11438
   Abstract »    Full Text »    PDF »
RNA Recombination of Hepatitis Delta Virus in Natural Mixed-Genotype Infection and Transfected Cultured Cells.
T.-C. Wang and M. Chao (2005)
J. Virol. 79, 2221-2229
   Abstract »    Full Text »    PDF »
Reconstitution in cultured cells of replicating HDV RNA from pairs of less than full-length RNAs.
S. O. GUDIMA, J. CHANG, and J. M. TAYLOR (2005)
RNA 11, 90-98
   Abstract »    Full Text »    PDF »
Molecular Phylogenetic Analyses Indicate a Wide and Ancient Radiation of African Hepatitis Delta Virus, Suggesting a Deltavirus Genus of at Least Seven Major Clades.
N. Radjef, E. Gordien, V. Ivaniushina, E. Gault, P. Anais, T. Drugan, J.-C. Trinchet, D. Roulot, M. Tamby, M. C. Milinkovitch, et al. (2004)
J. Virol. 78, 2537-2544
   Abstract »    Full Text »    PDF »
The Double-stranded RNA-activated Kinase, PKR, Can Phosphorylate Hepatitis D Virus Small Delta Antigen at Functional Serine and Threonine Residues.
C.-W. Chen, Y.-G. Tsay, H.-L. Wu, C.-H. Lee, D.-S. Chen, and P.-J. Chen (2002)
J. Biol. Chem. 277, 33058-33067
   Abstract »    Full Text »    PDF »
Analysis of the Complete Genome Sequence of the Hz-1 Virus Suggests that It Is Related to Members of the Baculoviridae.
C.-H. Cheng, S.-M. Liu, T.-Y. Chow, Y.-Y. Hsiao, D.-P. Wang, J.-J. Huang, and H.-H. Chen (2002)
J. Virol. 76, 9024-9034
   Abstract »    Full Text »    PDF »
Efficient Hepatitis Delta Virus RNA Replication in Avian Cells Requires a Permissive Factor(s) from Mammalian Cells.
Y.-T. Liu, R. Brazas, and D. Ganem (2001)
J. Virol. 75, 7489-7493
   Abstract »    Full Text »    PDF »
Deleterious Effects of Hepatitis Delta Virus Replication on Host Cell Proliferation.
D. Wang, J. Pearlberg, Y.-T. Liu, and D. Ganem (2001)
J. Virol. 75, 3600-3604
   Abstract »    Full Text »
Interactions between Hepatitis Delta Virus Proteins.
G. Moraleda, K. Dingle, P. Biswas, J. Chang, H. Zuccola, J. Hogle, and J. Taylor (2000)
J. Virol. 74, 5509-5515
   Abstract »    Full Text »
Hepatitis Delta Virus Replication Generates Complexes of Large Hepatitis Delta Antigen and Antigenomic RNA That Affiliate with and Alter Nuclear Domain 10.
P. Bell, R. Brazas, D. Ganem, and G. G. Maul (2000)
J. Virol. 74, 5329-5336
   Abstract »    Full Text »
A cellular protein which binds hepatitis B virus but not hepatitis B surface antigen.
T. Harvey, T. Macnaughton, D. Park, and E. Gowans (1999)
J. Gen. Virol. 80, 607-615
   Abstract »
The Nucleolin Binding Activity of Hepatitis Delta Antigen Is Associated with Nucleolus Targeting.
C.-H. Lee, S. C. Chang, C.-J. Chen, and M.-F. Chang (1998)
J. Biol. Chem. 273, 7650-7656
   Abstract »    Full Text »    PDF »
Activation of Heterologous Gene Expression by the Large Isoform of Hepatitis Delta Antigen.
Y. Wei and D. Ganem (1998)
J. Virol. 72, 2089-2096
   Abstract »    Full Text »    PDF »
Delta-Interacting Protein A and the Origin of Hepatitis Delta Antigen.
M. Long, S. J. de Souza, W. Gilbert;, R. Brazas, and D. Ganem; (1997)
Science 276, 824-825
   Abstract »    Full Text »
Transcriptional Repression of p53 Promoter by Hepatitis C Virus Core Protein.
R. B. Ray, R. Steele, K. Meyer, and R. Ray (1997)
J. Biol. Chem. 272, 10983-10986
   Abstract »    Full Text »    PDF »
Stimulation of RNA Polymerase II Elongation by Hepatitis Delta Antigen.
Y. Yamaguchi, J. Filipovska, K. Yano, A. Furuya, N. Inukai, T. Narita, T. Wada, S. Sugimoto, M. M. Konarska, and H. Handa (2001)
Science 293, 124-127
   Abstract »    Full Text »    PDF »
Large Isoform of Hepatitis Delta Antigen Activates Serum Response Factor-associated Transcription.
T. Goto, N. Kato, S. K. Ono-Nita, H. Yoshida, M. Otsuka, Y. Shiratori, and M. Omata (2000)
J. Biol. Chem. 275, 37311-37316
   Abstract »    Full Text »    PDF »
The Nucleolar Phosphoprotein B23 Interacts with Hepatitis Delta Antigens and Modulates the Hepatitis Delta Virus RNA Replication.
W.-H. Huang, B. Y. M. Yung, W.-J. Syu, and Y.-H. W. Lee (2001)
J. Biol. Chem. 276, 25166-25175
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)