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Science 20 September 1996:
Vol. 273. no. 5282, pp. 1719 - 1722
DOI: 10.1126/science.273.5282.1719
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Reports

Regulation of a Neuronal Form of Focal Adhesion Kinase by Anandamide

Pascal Derkinderen, Madeleine Toutant, Ferran Burgaya, Marc Le Bert, Julio C. Siciliano, * Vittorio de Franciscis, dagger Michèle Gelman, Jean-Antoine Girault ddagger

Anandamide is an endogenous ligand for central cannabinoid receptors and is released after neuronal depolarization. Anandamide increased protein tyrosine phosphorylation in rat hippocampal slices and neurons in culture. The action of anandamide resulted from the inhibition of adenylyl cyclase and cyclic adenosine 3',5'-monophosphate-dependent protein kinase. One of the proteins phosphorylated in response to anandamide was an isoform of pp125-focal adhesion kinase (FAK+) expressed preferentially in neurons. Focal adhesion kinase is a tyrosine kinase involved in the interactions between the integrins and actin-based cytoskeleton. Thus, anandamide may exert neurotrophic effects and play a role in synaptic plasticity.

INSERM U 114, Chaire de Neuropharmacologie, Collège de France, 11 place Marcelin Berthelot, 75231 Paris cedex 05, France.
*   Present address: Departamento de Histología, Facultad de Medicina, Montevideo, Uruguay.

dagger    On leave of absence from Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli "Federico II," Naples, Italy.

ddagger    To whom correspondence should be addressed. E-mail: girault{at}infobiogen.fr

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