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Science 30 August 1996:
Vol. 273. no. 5279, pp. 1227 - 1231
DOI: 10.1126/science.273.5279.1227
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Reports

KUZ, a Conserved Metalloprotease-Disintegrin Protein with Two Roles in Drosophila Neurogenesis

Jenny Rooke, Duojia Pan, Tian Xu, * Gerald M. Rubin

During neurogenesis in Drosophila both neurons and nonneuronal cells are produced from a population of initially equivalent cells. The kuzbanian (kuz) gene described here is essential for the partitioning of neural and nonneuronal cells during development of both the central and peripheral nervous systems in Drosophila. Mosaic analyses indicated that kuz is required for cells to receive signals inhibiting the neural fate. These analyses further revealed that the development of a neuron requires a kuz-mediated positive signal from neighboring cells. The kuz gene encodes a metalloprotease-disintegrin protein with a highly conserved bovine homolog, raising the possibility that kuz homologs may act in similar processes during mammalian neurogenesis.

J. Rooke and T. Xu, Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.
D. Pan and G. M. Rubin, Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
*   To whom correspondence should be addressed.


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Roles of Meltrin beta /ADAM19 in the Processing of Neuregulin.
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