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Science 23 August 1996:
Vol. 273. no. 5278, pp. 1058 - 1073
DOI: 10.1126/science.273.5278.1058
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Articles

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

Carol J. Bult, Owen White, Gary J. Olsen, Lixin Zhou, Robert D. Fleischmann, Granger G. Sutton, Judith A. Blake, Lisa M. FitzGerald, Rebecca A. Clayton, Jeannine D. Gocayne, Anthony R. Kerlavage, Brian A. Dougherty, Jean-Francois Tomb, Mark D. Adams, Claudia I. Reich, Ross Overbeek, Ewen F. Kirkness, Keith G. Weinstock, Joseph M. Merrick, Anna Glodek, John L. Scott, Neil S. M. Geoghagen, Janice F. Weidman, Joyce L. Fuhrmann, Dave Nguyen, Teresa R. Utterback, Jenny M. Kelley, Jeremy D. Peterson, Paul W. Sadow, Michael C. Hanna, Matthew D. Cotton, Kevin M. Roberts, Margaret A. Hurst, Brian P. Kaine, Mark Borodovsky, Hans-Peter Klenk, Claire M. Fraser, Hamilton O. Smith, Carl R. Woese, J. Craig Venter *

The complete 1.66-megabase pair genome sequence of an autotrophic archaeon, Methanococcus jannaschii, and its 58- and 16-kilobase pair extrachromosomal elements have been determined by whole-genome random sequencing. A total of 1738 predicted protein-coding genes were identified; however, only a minority of these (38 percent) could be assigned a putative cellular role with high confidence. Although the majority of genes related to energy production, cell division, and metabolism in M. jannaschii are most similar to those found in Bacteria, most of the genes involved in transcription, translation, and replication in M. jannaschii are more similar to those found in Eukaryotes.

[Web Site] The Methanococcus jannaschii Genome Database


G. J. Olsen, C. I. Reich, B. P. Kaine, and C. R. Woese are in the Microbiology Department, University of Illinois, Champaign-Urbana, IL 61801, USA. R. Overbeek is with the Division of Mathematics and Computer Science, Argonne National Laboratory, Argonne, IL 60439, USA. J. M. Merrick is in the Department of Microbiology, State University of New York, Buffalo, NY 14214, USA. M. Borodovsky is with the School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA. H. O. Smith is in the Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. All other authors are with The Institute for Genomic Research (TIGR), Rockville, MD 20850, USA.
*   To whom correspondence should be addressed at The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.


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Nonrandom Tripeptide Sequence Distributions at Protein Carboxyl Termini.
G. J. Gatto Jr. and J. M. Berg (2003)
Genome Res. 13, 617-623
   Abstract »    Full Text »    PDF »
Compositional Changes in RNA, DNA and Proteins for Bacterial Adaptation to Higher and Lower Temperatures.
H. Nakashima, S. Fukuchi, and K. Nishikawa (2003)
J. Biochem. 133, 507-513
   Abstract »    Full Text »    PDF »
The Methanococcus jannaschii dCTP Deaminase Is a Bifunctional Deaminase and Diphosphatase.
H. Li, H. Xu, D. E. Graham, and R. H. White (2003)
J. Biol. Chem. 278, 11100-11106
   Abstract »    Full Text »    PDF »
The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases.
S. Kamtekar, W. D. Kennedy, J. Wang, C. Stathopoulos, D. Soll, and T. A. Steitz (2003)
PNAS 100, 1673-1678
   Abstract »    Full Text »    PDF »
Rates and Consequences of Recombination between rRNA Operons.
J. G. Hashimoto, B. S. Stevenson, and T. M. Schmidt (2003)
J. Bacteriol. 185, 966-972
   Abstract »    Full Text »    PDF »
A Novel Neutral Amino Acid Transporter from the Hyperthermophilic Archaeon Thermococcus sp. KS-1.
S. Akahane, H. Kamata, H. Yagisawa, and H. Hirata (2003)
J. Biochem. 133, 173-180
   Abstract »    Full Text »    PDF »
Evaluation of PCR Amplification Bias by Terminal Restriction Fragment Length Polymorphism Analysis of Small-Subunit rRNA and mcrA Genes by Using Defined Template Mixtures of Methanogenic Pure Cultures and Soil DNA Extracts.
T. Lueders and M. W. Friedrich (2003)
Appl. Envir. Microbiol. 69, 320-326
   Abstract »    Full Text »    PDF »
Inactivation of the selB Gene in Methanococcus maripaludis: Effect on Synthesis of Selenoproteins and Their Sulfur-Containing Homologs.
M. Rother, I. Mathes, F. Lottspeich, and A. Bock (2003)
J. Bacteriol. 185, 107-114
   Abstract »    Full Text »    PDF »
Regulatory Response of Methanococcus maripaludis to Alanine, an Intermediate Nitrogen Source.
T. J. Lie and J. A. Leigh (2002)
J. Bacteriol. 184, 5301-5306
   Abstract »    Full Text »    PDF »
Evolutionary Divergence of the Archaeal Aspartyl-tRNA Synthetases into Discriminating and Nondiscriminating Forms.
D. Tumbula-Hansen, L. Feng, H. Toogood, K. O. Stetter, and D. Soll (2002)
J. Biol. Chem. 277, 37184-37190
   Abstract »    Full Text »    PDF »
Cysteine Activation Is an Inherent in Vitro Property of Prolyl-tRNA Synthetases.
I. Ahel, C. Stathopoulos, A. Ambrogelly, A. Sauerwald, H. Toogood, T. Hartsch, and D. Soll (2002)
J. Biol. Chem. 277, 34743-34748
   Abstract »    Full Text »    PDF »
Dictionary-driven protein annotation.
I. Rigoutsos, T. Huynh, A. Floratos, L. Parida, and D. Platt (2002)
Nucleic Acids Res. 30, 3901-3916
   Abstract »    Full Text »    PDF »


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