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Science 9 August 1996:
Vol. 273. no. 5276, pp. 813 - 816
DOI: 10.1126/science.273.5276.813
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Reports

Genome Sequence of a Human Tumorigenic Poxvirus: Prediction of Specific Host Response-Evasion Genes

Tatiana G. Senkevich, Joachim J. Bugert, Jerry R. Sisler, Eugene V. Koonin, Gholamreza Darai, Bernard Moss *

Molluscum contagiosum virus (MCV) commonly causes asymptomatic cutaneous neoplasms in children and sexually active adults as well as persistent opportunistic acquired immunodeficiency syndrome (AIDS)-associated disease. Sequencing the 190-kilobase pair genome of MCV has now revealed that the virus potentially encodes 163 proteins, of which 103 have homologs in the smallpox virus. MCV lacks counterparts to 83 genes of the smallpox virus, including those important in suppression of host responses to infection, nucleotide biosynthesis, and cell proliferation. MCV possesses 59 genes that are predicted to encode previously uncharacterized proteins, including major histocompatibility complex class I, chemokine, and glutathione peroxidase homologs, which suggests that there are MCV-specific strategies for coexistence with the human host.

T. G. Senkevich, J. J. Bugert, J. R. Sisler, B. Moss, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0455, USA.
E. V. Koonin, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
G. Darai, Institut für Medizinische Virologie, Universität Heidelberg, 69120 Heidelberg, Germany.
*   To whom correspondence should be addressed.


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J. Immunol. 161, 4066-4077
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Poxvirus Dilemmas -- Monkeypox, Smallpox, and Biologic Terrorism.
J. G. Breman and D.A. Henderson (1998)
N. Engl. J. Med. 339, 556-559
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DNA Packaging Mutant: Repression of the Vaccinia Virus A32 Gene Results in Noninfectious, DNA-Deficient, Spherical, Enveloped Particles.
M. C. Cassetti, M. Merchlinsky, E. J. Wolffe, A. S. Weisberg, and B. Moss (1998)
J. Virol. 72, 5769-5780
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Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
I. Damon, P. M. Murphy, and B. Moss (1998)
PNAS 95, 6403-6407
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The Envelope Protein Encoded by the A33R Gene Is Required for Formation of Actin-Containing Microvilli and Efficient Cell-to-Cell Spread of Vaccinia Virus.
R. L. Roper, E. J. Wolffe, A. Weisberg, and B. Moss (1998)
J. Virol. 72, 4192-4204
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Characterization of the Single-Stranded DNA Binding Protein Encoded by the Vaccinia Virus I3 Gene.
S. C. Rochester and P. Traktman (1998)
J. Virol. 72, 2917-2926
   Abstract »    Full Text »    PDF »
Molluscum Contagiosum Virus Topoisomerase: Purification, Activities, and Response to Inhibitors.
Y. Hwang, B. Wang, and F. D. Bushman (1998)
J. Virol. 72, 3401-3406
   Abstract »    Full Text »    PDF »
Blockade of Chemokine Activity by a Soluble Chemokine Binding Protein from Vaccinia Virus.
A. Alcami, J. A. Symons, P. D. Collins, T. J. Williams, and G. L. Smith (1998)
J. Immunol. 160, 624-633
   Abstract »    Full Text »    PDF »
The CC Chemokine I-309 Inhibits CCR8-dependent Infection by Diverse HIV-1 Strains.
R. Horuk, J. Hesselgesser, Y. Zhou, D. Faulds, M. Halks-Miller, S. Harvey, D. Taub, M. Samson, M. Parmentier, J. Rucker, et al. (1998)
J. Biol. Chem. 273, 386-391
   Abstract »    Full Text »    PDF »
Ultraviolet-Induced Cell Death Blocked by a Selenoprotein from a Human Dermatotropic Poxvirus.
J. L. Shisler, T. G. Senkevich, M. J. Berry, and B. Moss (1998)
Science 279, 102-105
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The 131-Amino-Acid Repeat Region of the Essential 39-Kilodalton Core Protein of Fowlpox Virus FP9, Equivalent to Vaccinia Virus A4L Protein, Is Nonessential and Highly Immunogenic.
D. Boulanger, P. Green, T. Smith, C.-P. Czerny, and M. A. Skinner (1998)
J. Virol. 72, 170-179
   Abstract »    Full Text »    PDF »
A Broad-Spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-Associated Herpesvirus.
T. N. Kledal, M. M. Rosenkilde, F. Coulin, G. Simmons, A. H. Johnsen, S. Alouani, C. A. Power, H. R. Lüttichau, J. Gerstoft, P. R. Clapham, et al. (1997)
Science 277, 1656-1659
   Abstract »    Full Text »
Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2.
M. D. Krathwohl, R. Hromas, D. R. Brown, H. E. Broxmeyer, and K. H. Fife (1997)
PNAS 94, 9875-9880
   Abstract »    Full Text »    PDF »
Resolution of Recalcitrant Molluscum Contagiosum Virus Lesions in Human Immunodeficiency Virus-Infected Patients Treated With Cidofovir.
K. P. Meadows, S. K. Tyring, A. T. Pavia, and T. M. Rallis (1997)
Arch Dermatol 133, 987-990
   Abstract »    PDF »
Molluscum Contagiosum: New Insights, New Directions.
P. L. Myskowski (1997)
Arch Dermatol 133, 1039-1041
   Abstract »    PDF »
A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis.
S. Hu, C. Vincenz, M. Buller, and V. M. Dixit (1997)
J. Biol. Chem. 272, 9621-9624
   Abstract »    Full Text »    PDF »
Mutational Analysis of 39Residues of Vaccinia DNA Topoisomerase Identifies Lys-220, Arg-223, and Asn-228 as Important for Covalent Catalysis.
C. Cheng, L. K. Wang, J. Sekiguchi, and S. Shuman (1997)
J. Biol. Chem. 272, 8263-8269
   Abstract »    Full Text »    PDF »
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
J. Bertin, R. C. Armstrong, S. Ottilie, D. A. Martin, Y. Wang, S. Banks, G.-H. Wang, T. G. Senkevich, E. S. Alnemri, B. Moss, et al. (1997)
PNAS 94, 1172-1176
   Abstract »    Full Text »    PDF »
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV.
P. S. Moore, C. Boshoff, R. A. Weiss, and Y. Chang (1996)
Science 274, 1739-1744
   Abstract »    Full Text »


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