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Science 26 July 1996:
Vol. 273. no. 5274, pp. 507 - 510
DOI: 10.1126/science.273.5274.507
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Reports

The POU Factor Oct-6 and Schwann Cell Differentiation

Martine Jaegle, Wim Mandemakers, Ludo Broos, Ronald Zwart, Alar Karis, Pim Visser, Frank Grosveld, Dies Meijer *

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6-/- mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands.
*   To whom correspondence should be addressed. E-mail: meijer{at}gen.tgg.eur.nl


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   Abstract »    PDF »
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POU domain family values: flexibility, partnerships, and developmental codes..
A K Ryan and M G Rosenfeld (1997)
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   PDF »
Multiple promoter elements differentially regulate the expression of the mouse tenascin gene.
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   Abstract »    Full Text »    PDF »
XIPOU 2 is a potential regulator of Spemann's Organizer.
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Development 124, 1179-1189
   Abstract »    PDF »
Role of the Brn-3 Family of POU-domain Genes in the Development of the Auditory /Vestibular, Somatosensory, and Visual Systems.
M. Xiang, L. Gan, D. Li, L. Zhou, Z.-Y. Chen, D. Wagner, B.W. O'Malley Jr., W. Klein, and J. Nathans (1997)
Cold Spring Harb Symp Quant Biol 62, 325-336
   Abstract »    PDF »
Actin Plays a Role in Both Changes in Cell Shape and Gene- Expression Associated with Schwann Cell Myelination.
C. Fernandez-Valle, D. Gorman, A. M. Gomez, and M. B. Bunge (1997)
J. Neurosci. 17, 241-250
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »


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