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Science 19 July 1996:
Vol. 273. no. 5273, pp. 355 - 358
DOI: 10.1126/science.273.5273.355
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Reports

The Secreted Product of Xenopus Gene lunatic Fringe, a Vertebrate Signaling Molecule

Jane Y. Wu, Leng Wen, Wan-Jiang Zhang, Yi Rao *

Signaling molecules are essential for vertebrate embryonic development. Here, two Xenopus homologs of the Drosophila gene fringe, lunatic Fringe (lFng) and radical Fringe (rFng), were identified and the protein product of lFng further characterized. The messenger RNA of lFng is supplied as a maternal message. Its product is a precursor protein consisting of pre-, pro-, and mature regions. The mature lunatic Fringe protein is secreted extracellularly, and it induced mesodermal tissue formation in animal cap assays. These results indicate that secreted lunatic Fringe can induce mesoderm and reveal that the Fringe proteins are a family of vertebrate signaling molecules.

J. Y. Wu and W.-J. Zhang, Departments of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
L. Wen and Y. Rao, Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
* To whom correspondence should be addressed. E-mail: raoyi@thalamus.wustl.edu


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