Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 July 1996:
Vol. 273. no. 5272, pp. 245 - 248
DOI: 10.1126/science.273.5272.245
Prev | Table of Contents | Next

Reports

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Kazushi Kimura, Masaaki Ito, Mutsuki Amano, Kazuyasu Chihara, Yuko Fukata, Masato Nakafuku, Bunpei Yamamori, Jianhua Feng, Takeshi Nakano, Katsuya Okawa, Akihiro Iwamatsu, Kozo Kaibuchi *

The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP·RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP·RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.

K. Kimura, M. Amano, K. Chihara, Y. Fukata, M. Nakafuku, K. Kaibuchi, Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan.
M. Ito, B. Yamamori, J. Feng, T. Nakano, First Department of Internal Medicine, Mie University School of Medicine, Tsu 514, Japan.
K. Okawa and A. Iwamatsu, Central Laboratories for Key Technology, Kirin Brewery Company Limited, Yokohama 236, Japan.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cdk5-Dependent Regulation of Rho Activity, Cytoskeletal Contraction, and Epithelial Cell Migration via Suppression of Src and p190RhoGAP.
B. K. Tripathi and P. S. Zelenka (2009)
Mol. Cell. Biol. 29, 6488-6499
   Abstract »    Full Text »    PDF »
Role of cortical tension in bleb growth.
J.-Y. Tinevez, U. Schulze, G. Salbreux, J. Roensch, J.-F. Joanny, and E. Paluch (2009)
PNAS 106, 18581-18586
   Abstract »    Full Text »    PDF »
A Mediator of Rho-dependent Invasion Moonlights as a Methionine Salvage Enzyme.
Y. Kabuyama, E. S. Litman, P. D. Templeton, S. I. Metzner, E. S. Witze, G. M. Argast, S. J. Langer, K. Polvinen, Y. Shellman, D. Chan, et al. (2009)
Mol. Cell. Proteomics 8, 2308-2320
   Abstract »    Full Text »    PDF »
Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles.
C. Gally, F. Wissler, H. Zahreddine, S. Quintin, F. Landmann, and M. Labouesse (2009)
Development 136, 3109-3119
   Abstract »    Full Text »    PDF »
Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions.
C. Albiges-Rizo, O. Destaing, B. Fourcade, E. Planus, and M. R. Block (2009)
J. Cell Sci. 122, 3037-3049
   Abstract »    Full Text »    PDF »
ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton.
C. M. Van Itallie, A. S. Fanning, A. Bridges, and J. M. Anderson (2009)
Mol. Biol. Cell 20, 3930-3940
   Abstract »    Full Text »    PDF »
Phosphorylation-dependent Autoinhibition of Myosin Light Chain Phosphatase Accounts for Ca2+ Sensitization Force of Smooth Muscle Contraction.
A. Khromov, N. Choudhury, A. S. Stevenson, A. V. Somlyo, and M. Eto (2009)
J. Biol. Chem. 284, 21569-21579
   Abstract »    Full Text »    PDF »
Cyclic Mechanical Stress and Trabecular Meshwork Cell Contractility.
R. F. Ramos, G. M. Sumida, and W. D. Stamer (2009)
Invest. Ophthalmol. Vis. Sci. 50, 3826-3832
   Abstract »    Full Text »    PDF »
TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism.
X. Wu, R. Guo, P. Chen, Q. Wang, and P. N. Cunningham (2009)
Am J Physiol Renal Physiol 297, F316-F326
   Abstract »    Full Text »    PDF »
Rho-regulated Myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation.
D. C. Weiser, R. H. Row, and D. Kimelman (2009)
Development 136, 2375-2384
   Abstract »    Full Text »    PDF »
Analysis of Pulmonary Vasodilator Responses to SB-772077-B [4-(7-((3-Amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a Novel Aminofurazan-Based Rho Kinase Inhibitor.
J. S. Dhaliwal, A. M. Badejo Jr., D. B. Casey, S. N. Murthy, and P. J. Kadowitz (2009)
J. Pharmacol. Exp. Ther. 330, 334-341
   Abstract »    Full Text »    PDF »
RhoA/Rho Kinase Signaling in the Cumulus Mediates Extracellular Matrix Assembly.
R. Yodoi, S. Tamba, K. Morimoto, E. Segi-Nishida, M. Nishihara, A. Ichikawa, S. Narumiya, and Y. Sugimoto (2009)
Endocrinology 150, 3345-3352
   Abstract »    Full Text »    PDF »
Endothelial cell traction and ECM density influence both capillary morphogenesis and maintenance in 3-D.
E. Kniazeva and A. J. Putnam (2009)
Am J Physiol Cell Physiol 297, C179-C187
   Abstract »    Full Text »    PDF »
Epidermal Growth Factor-induced Contraction Regulates Paxillin Phosphorylation to Temporally Separate Traction Generation from De-adhesion.
I. C. Schneider, C. K. Hays, and C. M. Waterman (2009)
Mol. Biol. Cell 20, 3155-3167
   Abstract »    Full Text »    PDF »
Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.
N. Yamamoto, T. Okano, X. Ma, R. S. Adelstein, and M. W. Kelley (2009)
Development 136, 1977-1986
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinase Pathways Contribute to Hypercontractility and Increased Ca2+ Sensitization in Murine Experimental Colitis.
E. Ihara, P. L. Beck, M. Chappellaz, J. Wong, S. A. Medlicott, and J. A. MacDonald (2009)
Mol. Pharmacol. 75, 1031-1041
   Abstract »    Full Text »    PDF »
Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
S.-K. Choi, D.-S. Ahn, and Y.-H. Lee (2009)
Cardiovasc Res 82, 324-332
   Abstract »    Full Text »    PDF »
Rock 'n' Rho: regulation of ion channels.
L.-M. Jin (2009)
Am J Physiol Heart Circ Physiol 296, H908-H909
   Full Text »    PDF »
Positioning cytokinesis.
S. Oliferenko, T. G. Chew, and M. K. Balasubramanian (2009)
Genes & Dev. 23, 660-674
   Abstract »    Full Text »    PDF »
The Role of Lysophosphatidic Acid Receptor (LPA1) in the Oxygen-Induced Retinal Ganglion Cell Degeneration.
C. Yang, J. Lafleur, B. R. Mwaikambo, T. Zhu, C. Gagnon, S. Chemtob, A. Di Polo, and P. Hardy (2009)
Invest. Ophthalmol. Vis. Sci. 50, 1290-1298
   Abstract »    Full Text »    PDF »
Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth.
N. S. Funa, V. Kriz, G. Zang, G. Calounova, B. Akerblom, J. Mares, E. Larsson, Y. Sun, C. Betsholtz, and M. Welsh (2009)
Cancer Res. 69, 2141-2148
   Abstract »    Full Text »    PDF »
Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameter.
E. W. Inscho, A. K. Cook, R. C. Webb, and L.-M. Jin (2009)
Am J Physiol Renal Physiol 296, F590-F597
   Abstract »    Full Text »    PDF »
Centrosome/Spindle Pole-associated Protein Regulates Cytokinesis via Promoting the Recruitment of MyoGEF to the Central Spindle.
M. Asiedu, D. Wu, F. Matsumura, and Q. Wei (2009)
Mol. Biol. Cell 20, 1428-1440
   Abstract »    Full Text »    PDF »
ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells.
Y. Wang, X. R. Zheng, N. Riddick, M. Bryden, W. Baur, X. Zhang, and H. K. Surks (2009)
Circ. Res. 104, 531-540
   Abstract »    Full Text »    PDF »
The Role of Actomyosin Contractility in the Formation and Dynamics of Actin Bundles During Fibroblast Spreading.
Y. Senju and H. Miyata (2009)
J. Biochem. 145, 137-150
   Abstract »    Full Text »    PDF »
Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation.
J. H. Lee, T. Palaia, and L. Ragolia (2009)
Am J Physiol Cell Physiol 296, C327-C338
   Abstract »    Full Text »    PDF »
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway.
P. Flevaris, Z. Li, G. Zhang, Y. Zheng, J. Liu, and X. Du (2009)
Blood 113, 893-901
   Abstract »    Full Text »    PDF »
Integrins in cell migration - the actin connection.
M. Vicente-Manzanares, C. K. Choi, and A. R. Horwitz (2009)
J. Cell Sci. 122, 199-206
   Abstract »    Full Text »    PDF »
Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage.
R. Arita, Y. Hata, S. Nakao, T. Kita, M. Miura, S. Kawahara, S. Zandi, L. Almulki, F. Tayyari, H. Shimokawa, et al. (2009)
Diabetes 58, 215-226
   Abstract »    Full Text »    PDF »
CPI-17 Silencing-Reduced Responsiveness in Control and TNF-{alpha}-Treated Human Bronchi.
C. Morin, M. Sirois, V. Echave, and E. Rousseau (2008)
Am. J. Respir. Cell Mol. Biol. 39, 638-643
   Abstract »    Full Text »    PDF »
Medial Temporal Lobe Involvement in an Implicit Memory Task: Evidence of Collaborating Implicit and Explicit Memory Systems from fMRI and Alzheimer's Disease.
P. Koenig, E. E. Smith, V. Troiani, C. Anderson, P. Moore, and M. Grossman (2008)
Cereb Cortex 18, 2831-2843
   Abstract »    Full Text »    PDF »
Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries.
E. R. Injeti, R. J. Sandoval, J. M. Williams, A. V. Smolensky, L. E. Ford, and W. J. Pearce (2008)
Am J Physiol Heart Circ Physiol 295, H2289-H2298
   Abstract »    Full Text »    PDF »
Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery.
G. A. Knock, V. A. Snetkov, Y. Shaifta, S. Drndarski, J. P.T. Ward, and P. I. Aaronson (2008)
Cardiovasc Res 80, 453-462
   Abstract »    Full Text »    PDF »
Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation.
J. Riise, C. H.T. Nguyen, E. Qvigstad, D. L. Sandnes, J.-B. Osnes, T. Skomedal, F. O. Levy, and K. A. Krobert (2008)
Cardiovasc Res 80, 407-415
   Abstract »    Full Text »    PDF »
The C-Terminal Tail Region of Nonmuscle Myosin II Directs Isoform-specific Distribution in Migrating Cells.
J. C. Sandquist and A. R. Means (2008)
Mol. Biol. Cell 19, 5156-5167
   Abstract »    Full Text »    PDF »
Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling.
X. Huang, D. Wu, H. Jin, D. Stupack, and J. Y.J. Wang (2008)
J. Cell Biol. 183, 711-723
   Abstract »    Full Text »    PDF »
Apolipoprotein(a), through Its Strong Lysine-binding Site in KIV10, Mediates Increased Endothelial Cell Contraction and Permeability via a Rho/Rho Kinase/MYPT1-dependent Pathway.
T. Cho, Y. Jung, and M. L. Koschinsky (2008)
J. Biol. Chem. 283, 30503-30512
   Abstract »    Full Text »    PDF »
Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation.
V. E. Foe and G. von Dassow (2008)
J. Cell Biol. 183, 457-470
   Abstract »    Full Text »    PDF »
An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning.
G. M. Odell and V. E. Foe (2008)
J. Cell Biol. 183, 471-483
   Abstract »    Full Text »    PDF »
Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat.
A. M. Badejo Jr., J. S. Dhaliwal, D. B. Casey, T. B. Gallen, A. J. Greco, and P. J. Kadowitz (2008)
Am J Physiol Lung Cell Mol Physiol 295, L828-L836
   Abstract »    Full Text »    PDF »
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from G{alpha}12/13 and G{alpha}11/q.
J. Gavard and J. S. Gutkind (2008)
J. Biol. Chem. 283, 29888-29896
   Abstract »    Full Text »    PDF »
Regulation of RhoA-dependent ROCKII activation by Shp2.
H.-H. Lee and Z.-F. Chang (2008)
J. Cell Biol. 181, 999-1012
   Abstract »    Full Text »    PDF »
Mechanotransduction - a field pulling together?.
C. S. Chen (2008)
J. Cell Sci. 121, 3285-3292
   Abstract »    Full Text »    PDF »
Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
H.-W. Wang, P.-Y. Liu, N. Oyama, Y. Rikitake, S. Kitamoto, J. Gitlin, J. K. Liao, and W. A. Boisvert (2008)
FASEB J 22, 3561-3570
   Abstract »    Full Text »    PDF »
Role of RhoA in Activity-Dependent Cortical Axon Branching.
S. Ohnami, M. Endo, S. Hirai, N. Uesaka, Y. Hatanaka, T. Yamashita, and N. Yamamoto (2008)
J. Neurosci. 28, 9117-9121
   Abstract »    Full Text »    PDF »
Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces.
D. Rosel, J. Brabek, O. Tolde, C. T. Mierke, D. P. Zitterbart, C. Raupach, K. Bicanova, P. Kollmannsberger, D. Pankova, P. Vesely, et al. (2008)
Mol. Cancer Res. 6, 1410-1420
   Abstract »    Full Text »    PDF »
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro.
K. Ghosh, C. K. Thodeti, A. C. Dudley, A. Mammoto, M. Klagsbrun, and D. E. Ingber (2008)
PNAS 105, 11305-11310
   Abstract »    Full Text »    PDF »
Rho kinases regulate corneal epithelial wound healing.
J. Yin and F.-S. X. Yu (2008)
Am J Physiol Cell Physiol 295, C378-C387
   Abstract »    Full Text »    PDF »
Insulin signalling in the heart.
L. Bertrand, S. Horman, C. Beauloye, and J.-L. Vanoverschelde (2008)
Cardiovasc Res 79, 238-248
   Abstract »    Full Text »    PDF »
RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease.
F. Peng, D. Wu, B. Gao, A. J. Ingram, B. Zhang, K. Chorneyko, R. McKenzie, and J. C. Krepinsky (2008)
Diabetes 57, 1683-1692
   Abstract »    Full Text »    PDF »
Rho-Kinase Inhibitors Augment the Inhibitory Effect of Propofol on Rat Bronchial Smooth Muscle Contraction.
M. Hanazaki, M. Yokoyama, K. Morita, A. Kohjitani, H. Sakai, Y. Chiba, and M. Misawa (2008)
Anesth. Analg. 106, 1765-1771
   Abstract »    Full Text »    PDF »
Roles of Necl-5/Poliovirus Receptor and Rho-associated Kinase (ROCK) in the Regulation of Transformation of Integrin {alpha}V{beta}3-based Focal Complexes into Focal Adhesions.
Y. Nagamatsu, Y. Rikitake, M. Takahashi, Y. Deki, W. Ikeda, K.-i. Hirata, and Y. Takai (2008)
J. Biol. Chem. 283, 14532-14541
   Abstract »    Full Text »    PDF »
Isoform B of myosin II heavy chain mediates actomyosin contractility during TNF{alpha}-induced apoptosis.
S. Solinet and M. L. Vitale (2008)
J. Cell Sci. 121, 1681-1692
   Abstract »    Full Text »    PDF »
Effects of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor, Fluvastatin, on Coronary Spasm After Withdrawal of Calcium-Channel Blockers.
H. Yasue, Y. Mizuno, E. Harada, T. Itoh, H. Nakagawa, M. Nakayama, H. Ogawa, S. Tayama, T. Honda, S. Hokimoto, et al. (2008)
J. Am. Coll. Cardiol. 51, 1742-1748
   Abstract »    Full Text »    PDF »
GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA.
Y.-C. Chang, P. Nalbant, J. Birkenfeld, Z.-F. Chang, and G. M. Bokoch (2008)
Mol. Biol. Cell 19, 2147-2153
   Abstract »    Full Text »    PDF »
Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration.
C. Le Clainche and M.-F. Carlier (2008)
Physiol Rev 88, 489-513
   Abstract »    Full Text »    PDF »
PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis.
S. F. G. van Helden, M. M. Oud, B. Joosten, N. Peterse, C. G. Figdor, and F. N. van Leeuwen (2008)
J. Cell Sci. 121, 1096-1106
   Abstract »    Full Text »    PDF »
Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.
B. R. S. Broughton, B. R. Walker, and T. C. Resta (2008)
Am J Physiol Lung Cell Mol Physiol 294, L797-L806
   Abstract »    Full Text »    PDF »
Dual Modulation of Airway Smooth Muscle Contraction by Th2 Cytokines via Matrix Metalloproteinase-1 Production.
Y. Ohta, M. Hayashi, T. Kanemaru, K. Abe, Y. Ito, and M. Oike (2008)
J. Immunol. 180, 4191-4199
   Abstract »    Full Text »    PDF »
Intraocular Pressure-Lowering Effects and Safety of Topical Administration of a Selective ROCK Inhibitor, SNJ-1656, in Healthy Volunteers.
H. Tanihara, M. Inatani, M. Honjo, H. Tokushige, J. Azuma, and M. Araie (2008)
Arch Ophthalmol 126, 309-315
   Abstract »    Full Text »    PDF »
Roles of Rho Guanosine 5'-Triphosphatase A, Rho Kinases, and Extracellular Signal Regulated Kinase (1/2) in Prostaglandin E2-Mediated Migration of First-Trimester Human Extravillous Trophoblast.
C. Nicola, A. Chirpac, P. K. Lala, and C. Chakraborty (2008)
Endocrinology 149, 1243-1251
   Abstract »    Full Text »    PDF »
Proinsulin C-peptide constricts glomerular afferent arterioles in diabetic mice. A potential renoprotective mechanism.
L. Nordquist, E. Y. Lai, M. Sjoquist, A. Patzak, and A. E. G. Persson (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R836-R841
   Abstract »    Full Text »    PDF »
A Novel Regulatory Mechanism of Myosin Light Chain Phosphorylation via Binding of 14-3-3 to Myosin Phosphatase.
Y. Koga and M. Ikebe (2008)
Mol. Biol. Cell 19, 1062-1071
   Abstract »    Full Text »    PDF »
iPLA2{beta}: front and center in human monocyte chemotaxis to MCP-1.
R. S. Mishra, K. A. Carnevale, and M. K. Cathcart (2008)
J. Exp. Med. 205, 347-359
   Abstract »    Full Text »    PDF »
Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways.
Y. Xie, E-J. Tan, S. Wee, E. Manser, L. Lim, and C.-G. Koh (2008)
J. Cell Sci. 121, 514-521
   Abstract »    Full Text »    PDF »
EET Displays Anti-Inflammatory Effects in TNF-{alpha} Stimulated Human Bronchi: Putative Role of CPI-17.
C. Morin, M. Sirois, V. Echave, M. M. Gomes, and E. Rousseau (2008)
Am. J. Respir. Cell Mol. Biol. 38, 192-201
   Abstract »    Full Text »    PDF »
Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells.
M. Yamamoto, S. H. Ramirez, S. Sato, T. Kiyota, R. L. Cerny, K. Kaibuchi, Y. Persidsky, and T. Ikezu (2008)
Am. J. Pathol. 172, 521-533
   Abstract »    Full Text »    PDF »
B-RAF Regulation of Rnd3 Participates in Actin Cytoskeletal and Focal Adhesion Organization.
R. M. Klein, L. S. Spofford, E. V. Abel, A. Ortiz, and A. E. Aplin (2008)
Mol. Biol. Cell 19, 498-508
   Abstract »    Full Text »    PDF »
Interaction between src family kinases and rho-kinase in agonist-induced Ca2+-sensitization of rat pulmonary artery.
G. A. Knock, Y. Shaifta, V. A. Snetkov, B. Vowles, S. Drndarski, J. P.T. Ward, and P. I. Aaronson (2008)
Cardiovasc Res 77, 570-579
   Abstract »    Full Text »    PDF »
Activation of Rho Kinase by TNF-{alpha} Is Required for JNK Activation in Human Pulmonary Microvascular Endothelial Cells.
P. Y. Mong, C. Petrulio, H. L. Kaufman, and Q. Wang (2008)
J. Immunol. 180, 550-558
   Abstract »    Full Text »    PDF »
The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.
P. Komalavilas, R. B. Penn, C. R. Flynn, J. Thresher, L. B. Lopes, E. J. Furnish, M. Guo, M. A. Pallero, J. E. Murphy-Ullrich, and C. M. Brophy (2008)
Am J Physiol Lung Cell Mol Physiol 294, L69-L78
   Abstract »    Full Text »    PDF »
Novel Functions of Ect2 in Polar Lamellipodia Formation and Polarity Maintenance during "Contractile Ring-Independent" Cytokinesis in Adherent Cells.
M. Kanada, A. Nagasaki, and T. Q.P. Uyeda (2008)
Mol. Biol. Cell 19, 8-16
   Abstract »    Full Text »    PDF »
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement.
R. A. Lacalle, R. M. Peregil, J. P. Albar, E. Merino, C. Martinez-A, I. Merida, and S. Manes (2007)
J. Cell Biol. 179, 1539-1553
   Abstract »    Full Text »    PDF »
Type I{gamma} PIP Kinase Is a Novel Uropod Component that Regulates Rear Retraction during Neutrophil Chemotaxis.
M. A. Lokuta, M. A. Senetar, D. A. Bennin, P. A. Nuzzi, K. T. Chan, V. L. Ott, and A. Huttenlocher (2007)
Mol. Biol. Cell 18, 5069-5080
   Abstract »    Full Text »    PDF »
The Rap GTPase Activator Drosophila PDZ-GEF Regulates Cell Shape in Epithelial Migration and Morphogenesis.
B. Boettner and L. Van Aelst (2007)
Mol. Cell. Biol. 27, 7966-7980
   Abstract »    Full Text »    PDF »
A molecular switch that controls cell spreading and retraction.
P. Flevaris, A. Stojanovic, H. Gong, A. Chishti, E. Welch, and X. Du (2007)
J. Cell Biol. 179, 553-565
   Abstract »    Full Text »    PDF »
Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery.
N. Takizawa, R. Ikebe, M. Ikebe, and E. J. Luna (2007)
J. Cell Sci. 120, 3792-3803
   Abstract »    Full Text »    PDF »
Lysoplasmenylcholine increases neutrophil adherence to human coronary artery endothelial cells.
M. C. White, P. Rastogi, and J. McHowat (2007)
Am J Physiol Cell Physiol 293, C1467-C1471
   Abstract »    Full Text »    PDF »
Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats.
J. S. Dhaliwal, D. B. Casey, A. J. Greco, A. M. Badejo Jr., T. B. Gallen, S. N. Murthy, B. D. Nossaman, A. L. Hyman, and P. J. Kadowitz (2007)
Am J Physiol Lung Cell Mol Physiol 293, L1306-L1313
   Abstract »    Full Text »    PDF »
ROK contribution to endothelin-mediated contraction in aorta and mesenteric arteries following intermittent hypoxia/hypercapnia in rats.
K. J. Allahdadi, B. R. Walker, and N. L. Kanagy (2007)
Am J Physiol Heart Circ Physiol 293, H2911-H2918
   Abstract »    Full Text »    PDF »
Actin stress fibres.
S. Pellegrin and H. Mellor (2007)
J. Cell Sci. 120, 3491-3499
   Abstract »    Full Text »    PDF »
ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases.
A. Schmandke, A. Schmandke, and S. M. Strittmatter (2007)
Neuroscientist 13, 454-469
   Abstract »    PDF »
Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle.
E. Ihara, L. Moffat, J. Ostrander, M. P. Walsh, and J. A. MacDonald (2007)
Am J Physiol Gastrointest Liver Physiol 293, G699-G710
   Abstract »    Full Text »    PDF »
Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats.
H. Ikeda, Y. Kume, K. Tejima, T. Tomiya, T. Nishikawa, N. Watanabe, N. Ohtomo, M. Arai, C. Arai, M. Omata, et al. (2007)
Am J Physiol Gastrointest Liver Physiol 293, G911-G917
   Abstract »    Full Text »    PDF »
Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family.
C. Csortos, I. Kolosova, and A. D. Verin (2007)
Am J Physiol Lung Cell Mol Physiol 293, L843-L854
   Abstract »    Full Text »    PDF »
Comparison of gel contraction mediated by airway smooth muscle cells from patients with and without asthma.
H. Matsumoto, L. M Moir, B. G G Oliver, J. K Burgess, M. Roth, J. L Black, and B. E McParland (2007)
Thorax 62, 848-854
   Abstract »    Full Text »    PDF »
Postnatal maturation modulates relationships among cytosolic Ca2+, myosin light chain phosphorylation, and contractile tone in ovine cerebral arteries.
R. J. Sandoval, E. R. Injeti, W. T. Gerthoffer, and W. J. Pearce (2007)
Am J Physiol Heart Circ Physiol 293, H2183-H2192
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)