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Science 5 July 1996:
Vol. 273. no. 5271, pp. 70 - 74
DOI: 10.1126/science.273.5271.70
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Articles

The Aging Immune System: Primer and Prospectus

Richard A. Miller

Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.

The author is at the University of Michigan School of Medicine, University of Michigan Institute of Gerontology, and Ann Arbor Department of Veterans' Affairs Medical Center, Ann Arbor, MI 48109-0642, USA.


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Lymphocyte Modulation in a Baboon Model of Immunosenescence.
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J. Immunol. 169, 4697-4701
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Repertoire of Antibody Response in Bone Marrow and the Memory Response Are Differentially Affected in Aging Mice.
Y.-F. Lu and J. Cerny (2002)
J. Immunol. 169, 4920-4927
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Defective T Cell Priming Associated with Aging Can Be Rescued by Signaling Through 4-1BB (CD137).
P. Bansal-Pakala and M. Croft (2002)
J. Immunol. 169, 5005-5009
   Abstract »    Full Text »    PDF »
Exercise and Psychosocial Factors Modulate Immunity to Influenza Vaccine in Elderly Individuals.
M. L. Kohut, M. M. Cooper, M. S. Nickolaus, D. R. Russell, and J. E. Cunnick (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, M557-562
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C. Lacelle, H. Riol, S. Xu, Y.-J. Tang, Y.-S. Wang, Y.-L. Chuang, H.-S. Lin, M.-C. Chang, J. Liang, and E. Wang (2002)
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Bacterial Superantigen Exposure after Resolution of Influenza Virus Infection Perturbs the Virus-Specific Memory CD8+-T-Cell Repertoire.
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A. R. Falsey, M. A. Formica, and E. E. Walsh (2002)
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Fatal Inhalational Anthrax in a 94-Year-Old Connecticut Woman.
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Changes in Proinflammatory Cytokine Activity after Menopause.
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   Abstract »    Full Text »    PDF »
Age-Associated Loss of Bone Marrow Hematopoietic Cells Is Reversed by GH and Accompanies Thymic Reconstitution.
R. A. French, S. R. Broussard, W. A. Meier, C. Minshall, S. Arkins, J. F. Zachary, R. Dantzer, and K. W. Kelley (2002)
Endocrinology 143, 690-699
   Abstract »    Full Text »    PDF »
Defect in ERK2 and p54JNK Activation in Aging Mouse Splenocytes.
M. Li, C. Torres, C. Acuna-Castillo, R. Walter, E. M. Gardner, D. M. Murasko, and F. Sierra (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B41-47
   Abstract »    Full Text »
Decreased B16F10 Melanoma Growth and Impaired Vascularization in Telomerase-deficient Mice with Critically Short Telomeres.
S. Franco, I. Segura, H. H. Riese, and M. A. Blasco (2002)
Cancer Res. 62, 552-559
   Abstract »    Full Text »    PDF »
Value of Immunological Markers in Predicting Responsiveness to Influenza Vaccination in Elderly Individuals.
J. J. Goronzy, J. W. Fulbright, C. S. Crowson, G. A. Poland, W. M. O'Fallon, and C. M. Weyand (2001)
J. Virol. 75, 12182-12187
   Abstract »    Full Text »    PDF »
Interplay between telomere length and telomerase in human leukocyte differentiation and aging.
N.-p. Weng (2001)
J. Leukoc. Biol. 70, 861-867
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Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans.
S. K. Butcher, H. Chahal, L. Nayak, A. Sinclair, N. V. Henriquez, E. Sapey, D. O'Mahony, and J. M. Lord (2001)
J. Leukoc. Biol. 70, 881-886
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Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity.
O. Adolfsson, B. T. Huber, and S. N. Meydani (2001)
J. Immunol. 167, 3809-3817
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Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age.
C. Kollman, C. W. S. Howe, C. Anasetti, J. H. Antin, S. M. Davies, A. H. Filipovich, J. Hegland, N. Kamani, N. A. Kernan, R. King, et al. (2001)
Blood 98, 2043-2051
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Effect of Age on Respiratory Defense Mechanisms : Pulmonary Bacterial Clearance in Fischer 344 Rats After Intratracheal Instillation of Listeria monocytogenes.
J. M. Antonini, J. R. Roberts, R. W. Clarke, H.-M. Yang, M. W. Barger, J. Y. C. Ma, and D. N. Weissman (2001)
Chest 120, 240-249
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Heart Rate, Neuroendocrine, and Immunological Reactivity in Response to an Acute Laboratory Stressor.
M. R. Larson, R. Ader, and J. A. Moynihan (2001)
Psychosom Med 63, 493-501
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The Effect of Aging on Nasal Mucociliary Clearance, Beat Frequency, and Ultrastructure of Respiratory Cilia.
J. C. HO, K. N. CHAN, W. H. HU, W. K. LAM, L. ZHENG, G. L. TIPOE, J. SUN, R. LEUNG, and K. W. TSANG (2001)
Am. J. Respir. Crit. Care Med. 163, 983-988
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Single-Cell Analyses Reveal Two Defects in Peptide-Specific Activation of Naive T Cells from Aged Mice.
G. G. Garcia and R. A. Miller (2001)
J. Immunol. 166, 3151-3157
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