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Science 21 June 1996:
Vol. 272. no. 5269, pp. 1791 - 1794
DOI: 10.1126/science.272.5269.1791
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Reports

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Randolph J. Nudo, * Birute M. Wise, Frank SiFuentes, Garrett W. Milliken dagger

Substantial functional reorganization takes place in the motor cortex of adult primates after a focal ischemic infarct, as might occur in stroke. A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult squirrel monkeys. In the present study, retraining of skilled hand use after similar infarcts resulted in prevention of the loss of hand territory adjacent to the infarct. In some instances, the hand representations expanded into regions formerly occupied by representations of the elbow and shoulder. Functional reorganization in the undamaged motor cortex was accompanied by behavioral recovery of skilled hand function. These results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery.

Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
* To whom correspondence should be addressed. E-mail: rnudo{at}nba19.med.uth.tmc.edu
dagger Present address: Division of Restorative Neurology, Baylor College of Medicine, Houston, TX 77030, USA.


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Forced Use Treatment of Childhood Hemiparesis.
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Inosine induces axonal rewiring and improves behavioral outcome after stroke.
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