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Science 14 June 1996:
Vol. 272. no. 5268, pp. 1621 - 1625
DOI: 10.1126/science.272.5268.1621
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Research Articles

Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus

María Domínguez, Martina Brunner, Ernst Hafen, Konrad Basler

Drosophila limb development is organized by interactions between anterior and posterior compartment cells. Posterior cells continuously express and require engrailed (en) and secrete Hedgehog (Hh) protein. Anterior cells express the zinc-finger protein Cubitus interruptus (Ci). It is now shown that anterior cells lacking ci express hh and adopt posterior properties without expressing en. Increased levels of Ci can induce the expression of the Hh target gene decapentaplegic (dpp) in a Hh-independent manner. Thus, expression of Ci in anterior cells controls limb development (i) by restricting hh secretion to posterior cells and (ii) by conferring competence to respond to Hh by mediating the transduction of this signal.

The authors are at the Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.


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Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein-Taybi syndrome.
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Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos.
J. T. Ohlmeyer and D. Kalderon (1997)
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Development 124, 4697-4705
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The roles of hedgehog and engrailed in patterning adult abdominal segments of Drosophila.
A Kopp, M. Muskavitch, and I Duncan (1997)
Development 124, 3703-3714
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Control of cell fate and polarity in the adult abdominal segments of Drosophila by optomotor-blind.
A Kopp and I Duncan (1997)
Development 124, 3715-3726
   Abstract »    PDF »
Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc.
D. Strutt and M Mlodzik (1997)
Development 124, 3233-3240
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Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.
J Lee, K. Platt, P Censullo, and A Ruiz i Altaba (1997)
Development 124, 2537-2552
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Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen.
G Struhl, D. Barbash, and P. Lawrence (1997)
Development 124, 2155-2165
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A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.
H Sasaki, C Hui, M Nakafuku, and H Kondoh (1997)
Development 124, 1313-1322
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Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs.
T. Heslip, H Theisen, H Walker, and J. Marsh (1997)
Development 124, 1069-1078
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Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning.
J. Mullor, M Calleja, J Capdevila, and I Guerrero (1997)
Development 124, 1227-1237
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Control of Cell Growth and Fate by patched Genes.
R.L. Johnson and M.P. Scott (1997)
Cold Spring Harb Symp Quant Biol 62, 205-215
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Intercompartmental Signaling and the Regulation of vestigial Expression at the Dorsoventral Boundary of the Developing Drosophila Wing.
J. Kim, J. Magee, and S.B. Carroll (1997)
Cold Spring Harb Symp Quant Biol 62, 283-291
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Graded Sonic Hedgehog Signaling and the Specification of Cell Fate in the Ventral Neural Tube.
J. Ericson, J. Briscoe, P. Rashbass, V. van Heyningen, and T.M. Jessell (1997)
Cold Spring Harb Symp Quant Biol 62, 451-466
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Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing.
M. Singer, A Penton, V Twombly, F. Hoffmann, and W. Gelbart (1997)
Development 124, 79-89
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Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
R Mo, A. Freer, D. Zinyk, M. Crackower, J Michaud, H. Heng, K. Chik, X. Shi, L. Tsui, S. Cheng, et al. (1997)
Development 124, 113-123
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Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes.
J Hepker, Q. Wang, C. Motzny, R Holmgren, and T. Orenic (1997)
Development 124, 549-558
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araucan and caupolican provide a link between compartment subdivisions and patterning of sensory organs and veins in the Drosophila wing..
J L Gomez-Skarmeta and J Modolell (1996)
Genes & Dev. 10, 2935-2945
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Developmental territories created by mutual antagonism between Wingless and Decapentaplegic.
H Theisen, T. Haerry, M. O'Connor, and J. Marsh (1996)
Development 122, 3939-3948
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