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Science 7 June 1996:
Vol. 272. no. 5267, pp. 1495 - 1497
DOI: 10.1126/science.272.5267.1495
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Reports

A Subfamily of P-Type ATPases with Aminophospholipid Transporting Activity

Xiaojing Tang, Margaret S. Halleck, Robert A. Schlegel, Patrick Williamson *

The appearance of phosphatidylserine on the surface of animal cells triggers phagocytosis and blood coagulation. Normally, phosphatidylserine is confined to the inner leaflet of the plasma membrane by an aminophospholipid translocase, which has now been cloned and sequenced. The bovine enzyme is a member of a previously unrecognized subfamily of P-type adenosine triphosphatases (ATPases) that may have diverged from the primordial enzyme before the separation of the known families of ion-translocating ATPases. Studies in Saccharomyces cerevisiae suggest that aminophospholipid translocation is a general function of members of this family.

X. Tang and P. Williamson, Department of Biology, Amherst College, Amherst, MA 01002, USA.
M. S. Halleck and R. A. Schlegel, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
* To whom correspondence should be addressed.


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