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Science 17 May 1996:
Vol. 272. no. 5264, pp. 1023 - 1026
DOI: 10.1126/science.272.5264.1023
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Reports

Binding of GSK3beta to the APC-beta -Catenin Complex and Regulation of Complex Assembly

Bonnee Rubinfeld, Iris Albert, Emilio Porfiri, Carol Fiol, Susan Munemitsu, Paul Polakis *

The adenomatous polyposis coli gene (APC) is mutated in most colon cancers. The APC protein binds to the cellular adhesion molecule beta -catenin, which is a mammalian homolog of ARMADILLO, a component of the WINGLESS signaling pathway in Drosophila development. Here it is shown that when beta -catenin is present in excess, APC binds to another component of the WINGLESS pathway, glycogen synthase kinase 3beta (GSK3beta ), a mammalian homolog of Drosophila ZESTE WHITE 3. APC was a good substrate for GSK3beta in vitro, and the phosphorylation sites were mapped to the central region of APC. Binding of beta -catenin to this region was dependent on phosphorylation by GSK3beta .

B. Rubinfeld, I. Albert, E. Porfiri, S. Munemitsu, P. Polakis, Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA.
C. Fiol, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
* To whom correspondence should be addressed.


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J. Biol. Chem. 278, 14274-14283
   Abstract »    Full Text »    PDF »
GSK-3: tricks of the trade for a multi-tasking kinase.
B. W. Doble and J. R. Woodgett (2003)
J. Cell Sci. 116, 1175-1186
   Abstract »    Full Text »    PDF »
A {beta}-catenin survival signal is required for normal lobular development in the mammary gland.
S. B. Tepera, P. D. McCrea, and J. M. Rosen (2003)
J. Cell Sci. 116, 1137-1149
   Abstract »    Full Text »    PDF »
Protein kinase CKII regulates the interaction of {beta}-catenin with {alpha}-catenin and its protein stability.
S. Bek and R. Kemler (2003)
J. Cell Sci. 115, 4743-4753
   Abstract »    Full Text »    PDF »
A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment.
J. G. Wakefield, D. J. Stephens, and J. M. Tavare (2003)
J. Cell Sci. 116, 637-646
   Abstract »    Full Text »    PDF »
Regulation of Cyclooxygenase-2 Expression by the Wnt and Ras Pathways.
Y. Araki, S. Okamura, S. P. Hussain, M. Nagashima, P. He, M. Shiseki, K. Miura, and C. C. Harris (2003)
Cancer Res. 63, 728-734
   Abstract »    Full Text »    PDF »
Glycogen Synthase Kinase 3beta Phosphorylates Tau at Both Primed and Unprimed Sites. DIFFERENTIAL IMPACT ON MICROTUBULE BINDING.
J.-H. Cho and G. V. W. Johnson (2003)
J. Biol. Chem. 278, 187-193
   Abstract »    Full Text »    PDF »
Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
O. M. Sieber, K. Heinimann, P. Gorman, H. Lamlum, M. Crabtree, C. A. Simpson, D. Davies, K. Neale, S. V. Hodgson, R. R. Roylance, et al. (2002)
PNAS 99, 16910-16915
   Abstract »    Full Text »    PDF »
Fibroblast Growth Factor-2 Induces Lef/Tcf-dependent Transcription in Human Endothelial Cells.
W. Holnthoner, M. Pillinger, M. Groger, K. Wolff, A. W. Ashton, C. Albanese, P. Neumeister, R. G. Pestell, and P. Petzelbauer (2002)
J. Biol. Chem. 277, 45847-45853
   Abstract »    Full Text »    PDF »
Reduced Expression of Insulin-like Growth Factor I Receptors in MCF-7 Breast Cancer Cells Leads to a More Metastatic Phenotype.
P. A. Pennisi, V. Barr, N. P. Nunez, B. Stannard, and D. Le Roith (2002)
Cancer Res. 62, 6529-6537
   Abstract »    Full Text »    PDF »
Sporadic Fundic Gland Polyps with Epithelial Dysplasia : Evidence for Preferential Targeting for Mutations in the Adenomatous Polyposis Coli Gene.
S. C. Abraham, S. J. Park, L. Mugartegui, S. R. Hamilton, and T.-T. Wu (2002)
Am. J. Pathol. 161, 1735-1742
   Abstract »    Full Text »    PDF »
Transcriptional Activation of Interleukin-8 by beta -Catenin-Tcf4.
L. Levy, C. Neuveut, C.-A. Renard, P. Charneau, S. Branchereau, F. Gauthier, J. T. Van Nhieu, D. Cherqui, A.-F. Petit-Bertron, D. Mathieu, et al. (2002)
J. Biol. Chem. 277, 42386-42393
   Abstract »    Full Text »    PDF »
pygopus encodes a nuclear protein essential for Wingless/Wnt signaling.
T. Y. Belenkaya, C. Han, H. J. Standley, X. Lin, D. W. Houston, J. Heasman, and X. Lin (2002)
Development 129, 4089-4101
   Abstract »    Full Text »    PDF »
The Coiled Coil Region (Amino Acids 129-250) of the Tumor Suppressor Protein Adenomatous Polyposis Coli (APC). ITS STRUCTURE AND ITS INTERACTION WITH CHROMOSOME MAINTENANCE REGION 1 (Crm-1).
L. Tickenbrock, J. Cramer, I. R. Vetter, and O. Muller (2002)
J. Biol. Chem. 277, 32332-32338
   Abstract »    Full Text »    PDF »
Wnt-3A Enhances Bone Morphogenetic Protein-2-mediated Chondrogenesis of Murine C3H10T1/2 Mesenchymal Cells.
L. Fischer, G. Boland, and R. S. Tuan (2002)
J. Biol. Chem. 277, 30870-30878
   Abstract »    Full Text »    PDF »
Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3{beta}.
F. LIU, K. L. SCHAPHORST, A. D. VERIN, K. JACOBS, A. BIRUKOVA, R. M. DAY, N. BOGATCHEVA, D. P. BOTTARO, and J. G. N. GARCIA (2002)
FASEB J 16, 950-962
   Abstract »    Full Text »    PDF »
Expression and Characterization of GSK-3 Mutants and Their Effect on beta -Catenin Phosphorylation in Intact Cells.
T. Hagen, E. Di Daniel, A. A. Culbert, and A. D. Reith (2002)
J. Biol. Chem. 277, 23330-23335
   Abstract »    Full Text »    PDF »
Targeted inactivation of CTNNB1 reveals unexpected effects of beta -catenin mutation.
T. A. Chan, Z. Wang, L. H. Dang, B. Vogelstein, and K. W. Kinzler (2002)
PNAS 99, 8265-8270
   Abstract »    Full Text »    PDF »


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