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Science 17 May 1996:
Vol. 272. no. 5264, pp. 1010 - 1013
DOI: 10.1126/science.272.5264.1010
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Reports

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

Bernard Lakowski and Siegfried Hekimi *

The nematode worm Caenorhabditis elegans is a model system for the study of the genetic basis of aging. Maternal-effect mutations in four genes--clk-1, clk-2, clk-3, and gro-1-- interact genetically to determine both the duration of development and life-span. Analysis of the phenotypes of these mutants suggests the existence of a general physiological clock in the worm. Mutations in certain genes involved in dauer formation (an alternative larval stage induced by adverse conditions in which development is arrested) can also extend life-span, but the life extension of Clock mutants appears to be independent of these genes. The daf-2(e1370) clk-1(e2519) worms, which carry life-span-extending mutations from two different pathways, live nearly five times as long as wild-type worms.

Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montréal, Québec, Canada H3A 1B1.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1.
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Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice.
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