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Science 17 May 1996:
Vol. 272. no. 5264, pp. 1004 - 1007
DOI: 10.1126/science.272.5264.1004
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Reports

Specification of Pituitary Cell Lineages by the LIM Homeobox Gene Lhx3

Hui Z. Sheng, * Alexander B. Zhadanov, *dagger Bedrich Mosinger Jr., ddagger Tetsuya Fujii, § Stefano Bertuzzi, || Alexander Grinberg, Eric J. Lee, Sing-Ping Huang, Kathleen A. Mahon, Heiner Westphal #

During pituitary organogenesis, the progressive differentiation of distinct pituitary-specific cell lineages from a common primordium involves a series of developmental decisions and inductive interactions. Targeted gene disruption in mice showed that Lhx3, a LIM homeobox gene expressed in the pituitary throughout development, is essential for differentiation and proliferation of pituitary cell lineages. In mice homozygous for the Lhx3 mutation, Rathke's pouch formed but failed to grow and differentiate; such mice lacked both the anterior and intermediate lobes of the pituitary. The determination of all pituitary cell lineages, except the corticotrophs, was affected, suggesting that a distinct, Lhx3-independent ontogenetic pathway exists for the initial specification of this lineage.

Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
* Co-first authors.
dagger Present address: Department of Microbiology and Immunology, Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
ddagger Present address: Laboratory of Molecular Genetics, Institute for Mother and Child Care, 14710 Prague 4, Czech Republic.
§ Present address: Department of Obstetrics and Gynecology, Asahikawa Medical College, Nishikagura 4-5, Hokkaido, 078, Japan.
| On leave from Instituto di Microbiologia, Università Cattolica, Milan, Italy.
Co-senior authors.
# To whom correspondence should be addressed at Laboratory of Mammalian Genes and Development, NICHD, NIH, Building 6B, Room 413, Bethesda, MD 20892-2790, USA.


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A Role for the Homeobox Protein Distal-less 3 in the Activation of the Glycoprotein Hormone alpha Subunit Gene in Choriocarcinoma Cells.
M. S. Roberson, S. Meermann, M. I. Morasso, J. M. Mulvaney-Musa, and T. Zhang (2001)
J. Biol. Chem. 276, 10016-10024
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A Point Mutation in the LIM Domain of Lhx3 Reduces Activation of the Glycoprotein Hormone alpha -Subunit Promoter.
P. W. Howard and R. A. Maurer (2001)
J. Biol. Chem. 276, 19020-19026
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An Isoform-specific Inhibitory Domain Regulates the LHX3 LIM Homeodomain Factor Holoprotein and the Production of a Functional Alternate Translation Form.
K. W. Sloop, C. J. Dwyer, and S. J. Rhodes (2001)
J. Biol. Chem. 276, 36311-36319
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Tbx19, a tissue-selective regulator of POMC gene expression.
J. Liu, C. Lin, A. Gleiberman, K. A. Ohgi, T. Herman, H.-P. Huang, M.-J. Tsai, and M. G. Rosenfeld (2001)
PNAS 98, 8674-8679
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