Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 May 1996:
Vol. 272. no. 5263, pp. 872 - 877
DOI: 10.1126/science.272.5263.872
Prev | Table of Contents | Next

Reports

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

Yu Feng, Christopher C. Broder, Paul E. Kennedy, Edward A. Berger *

A cofactor for HIV-1 (human immunodeficiency virus-type 1) fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy. This protein, designated ``fusin,'' is a putative G protein-coupled receptor with seven transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1 Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin blocked cell fusion and infection with normal CD4-positive human target cells. Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophage-tropic HIV-1 isolates.

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparison of Human Immunodeficiency Virus Type 1 Tropism Profiles in Clinical Samples by the Trofile and MT-2 Assays.
E. Coakley, J. D. Reeves, W. Huang, M. Mangas-Ruiz, I. Maurer, A. M. Harskamp, S. Gupta, Y. Lie, C. J. Petropoulos, H. Schuitemaker, et al. (2009)
Antimicrob. Agents Chemother. 53, 4686-4693
   Abstract »    Full Text »    PDF »
Derivation and Characterization of a Simian Immunodeficiency Virus SIVmac239 Variant with Tropism for CXCR4.
G. Q. Del Prete, B. Haggarty, G. J. Leslie, A. P. O. Jordan, J. Romano, N. Wang, J. Wang, M. C. Holmes, D. C. Montefiori, and J. A. Hoxie (2009)
J. Virol. 83, 9911-9922
   Abstract »    Full Text »    PDF »
Matrix and Envelope Coevolution Revealed in a Patient Monitored since Primary Infection with Human Immunodeficiency Virus Type 1.
E. Beaumont, D. Vendrame, B. Verrier, E. Roch, F. Biron, F. Barin, F. Mammano, and D. Brand (2009)
J. Virol. 83, 9875-9889
   Abstract »    Full Text »    PDF »
Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain.
A. Kassa, N. Madani, A. Schon, H. Haim, A. Finzi, S.-H. Xiang, L. Wang, A. Princiotto, M. Pancera, J. Courter, et al. (2009)
J. Virol. 83, 8364-8378
   Abstract »    Full Text »    PDF »
Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeficiency Virus Type 1 Subtype.
R. Nedellec, M. Coetzer, N. Shimizu, H. Hoshino, V. R. Polonis, L. Morris, U. E. A. Martensson, J. Binley, J. Overbaugh, and D. E. Mosier (2009)
J. Virol. 83, 8353-8363
   Abstract »    Full Text »    PDF »
The Novel CXCR4 Antagonist KRH-3955 Is an Orally Bioavailable and Extremely Potent Inhibitor of Human Immunodeficiency Virus Type 1 Infection: Comparative Studies with AMD3100.
T. Murakami, S. Kumakura, T. Yamazaki, R. Tanaka, M. Hamatake, K. Okuma, W. Huang, J. Toma, J. Komano, M. Yanaka, et al. (2009)
Antimicrob. Agents Chemother. 53, 2940-2948
   Abstract »    Full Text »    PDF »
Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface.
L. Song, Z.-Y. J. Sun, K. E. Coleman, M. B. Zwick, J. S. Gach, J.-h. Wang, E. L. Reinherz, G. Wagner, and M. Kim (2009)
PNAS 106, 9057-9062
   Abstract »    Full Text »    PDF »
Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients.
L. Vandekerckhove, C. Verhofstede, and D. Vogelaers (2009)
J. Antimicrob. Chemother. 63, 1087-1096
   Abstract »    Full Text »    PDF »
Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain.
L. Gray, M. Roche, M. J. Churchill, J. Sterjovski, A. Ellett, P. Poumbourios, S. Sheffief, B. Wang, N. Saksena, D. F. J. Purcell, et al. (2009)
J. Virol. 83, 5430-5441
   Abstract »    Full Text »    PDF »
The human Pk histo-blood group antigen provides protection against HIV-1 infection.
N. Lund, M. L. Olsson, S. Ramkumar, D. Sakac, V. Yahalom, C. Levene, A. Hellberg, X.-Z. Ma, B. Binnington, D. Jung, et al. (2009)
Blood 113, 4980-4991
   Abstract »    Full Text »    PDF »
Identification of a Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Variant Resistant to Cold Inactivation.
A. Kassa, A. Finzi, M. Pancera, J. R. Courter, A. B. Smith III, and J. Sodroski (2009)
J. Virol. 83, 4476-4488
   Abstract »    Full Text »    PDF »
Maraviroc: A coreceptor CCR5 antagonist for management of HIV infection.
R. Yost, T. R. Pasquale, and E. G. Sahloff (2009)
Am. J. Health Syst. Pharm. 66, 715-726
   Abstract »    Full Text »    PDF »
Characterization of a Human Immunodeficiency Virus Type 1 V3 Deletion Mutation That Confers Resistance to CCR5 Inhibitors and the Ability To Use Aplaviroc-Bound Receptor.
K. M. Nolan, G. Q. Del Prete, A. P. O. Jordan, B. Haggarty, J. Romano, G. J. Leslie, and J. A. Hoxie (2009)
J. Virol. 83, 3798-3809
   Abstract »    Full Text »    PDF »
The Unexpected Pleiotropic Activities of RANTES.
J. A. Levy (2009)
J. Immunol. 182, 3945-3946
   Full Text »    PDF »
Patterns of Diversity in HIV-Related Loci among Subspecies of Chimpanzee: Concordance at CCR5 and Differences at CXCR4 and CX3CR1.
T.S. MacFie, E. Nerrienet, N.G. de Groot, R.E. Bontrop, and N.I. Mundy (2009)
Mol. Biol. Evol. 26, 719-727
   Abstract »    Full Text »    PDF »
Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.
L. Agrawal, C. R. Maxwell, P. J. Peters, P. R. Clapham, S. M. Liu, C. R. Mackay, and D. S. Strayer (2009)
J. Gen. Virol. 90, 710-722
   Abstract »    Full Text »    PDF »
Leukocyte trafficking in primary immunodeficiencies.
L. D. Notarangelo and R. Badolato (2009)
J. Leukoc. Biol. 85, 335-343
   Abstract »    Full Text »    PDF »
Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation.
M. A. Mines, J. S. Goodwin, L. E. Limbird, F.-F. Cui, and G.-H. Fan (2009)
J. Biol. Chem. 284, 5742-5752
   Abstract »    Full Text »    PDF »
Morphine Increases Brain Levels of Ferritin Heavy Chain Leading to Inhibition of CXCR4-Mediated Survival Signaling in Neurons.
R. Sengupta, S. Burbassi, S. Shimizu, S. Cappello, R. B. Vallee, J. B. Rubin, and O. Meucci (2009)
J. Neurosci. 29, 2534-2544
   Abstract »    Full Text »    PDF »
Analysis of Neutralization Specificities in Polyclonal Sera Derived from Human Immunodeficiency Virus Type 1-Infected Individuals.
Y. Li, K. Svehla, M. K. Louder, D. Wycuff, S. Phogat, M. Tang, S. A. Migueles, X. Wu, A. Phogat, G. M. Shaw, et al. (2009)
J. Virol. 83, 1045-1059
   Abstract »    Full Text »    PDF »
Citrullination of CXCL12 Differentially Reduces CXCR4 and CXCR7 Binding with Loss of Inflammatory and Anti-HIV-1 Activity via CXCR4.
S. Struyf, S. Noppen, T. Loos, A. Mortier, M. Gouwy, H. Verbeke, D. Huskens, S. Luangsay, M. Parmentier, K. Geboes, et al. (2009)
J. Immunol. 182, 666-674
   Abstract »    Full Text »    PDF »
CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth.
S. Singh, V. C. Bond, M. Powell, U. P. Singh, H. L. Bumpers, W. E. Grizzle, and J. W. Lillard Jr. (2009)
Mol. Cancer Ther. 8, 178-184
   Abstract »    Full Text »    PDF »
A short amino acid sequence containing tyrosine in the N-terminal region of G protein-coupled receptors is critical for their potential use as co-receptors for human and simian immunodeficiency viruses.
N. Shimizu, A. Tanaka, A. Oue, T. Mori, C. Apichartpiyakul, and H. Hoshino (2008)
J. Gen. Virol. 89, 3126-3136
   Abstract »    Full Text »    PDF »
Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.
A. Cagigi, F. Mowafi, L. V. Phuong Dang, K. Tenner-Racz, A. Atlas, S. Grutzmeier, P. Racz, F. Chiodi, and A. Nilsson (2008)
Blood 112, 4401-4410
   Abstract »    Full Text »    PDF »
Genetically Divergent Strains of Feline Immunodeficiency Virus from the Domestic Cat (Felis catus) and the African Lion (Panthera leo) Share Usage of CD134 and CXCR4 as Entry Receptors.
W. A. McEwan, E. L. McMonagle, N. Logan, R. C. Serra, P. Kat, S. VandeWoude, M. J. Hosie, and B. J. Willett (2008)
J. Virol. 82, 10953-10958
   Abstract »    Full Text »    PDF »
Resistance to human immunodeficiency virus type 1 (HIV-1) generated by lentivirus vector-mediated delivery of the CCR5{Delta}32 gene despite detectable expression of the HIV-1 co-receptors.
Q. Jin, J. Marsh, K. Cornetta, and G. Alkhatib (2008)
J. Gen. Virol. 89, 2611-2621
   Abstract »    Full Text »    PDF »
Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12.
C. T. Veldkamp, C. Seibert, F. C. Peterson, N. B. De la Cruz, J. C. Haugner III, H. Basnet, T. P. Sakmar, and B. F. Volkman (2008)
Science Signaling 1, ra4
   Abstract »    Full Text »    PDF »
SDF-1{alpha} Promotes Invasion of Head and Neck Squamous Cell Carcinoma by Activating NF-{kappa}B.
A. O. Rehman and C.-Y. Wang (2008)
J. Biol. Chem. 283, 19888-19894
   Abstract »    Full Text »    PDF »
Endogenous IL-32 Controls Cytokine and HIV-1 Production.
M. F. Nold, C. A. Nold-Petry, G. B. Pott, J. A. Zepp, M. T. Saavedra, S.-H. Kim, and C. A. Dinarello (2008)
J. Immunol. 181, 557-565
   Abstract »    Full Text »    PDF »
Psychosocial Influences on HIV-1 Disease Progression: Neural, Endocrine, and Virologic Mechanisms.
S. W. Cole (2008)
Psychosom Med 70, 562-568
   Abstract »    Full Text »    PDF »
Culturing of Human Mesenchymal Stem Cells as Three-dimensional Aggregates Induces Functional Expression of CXCR4 That Regulates Adhesion to Endothelial Cells.
I. A. Potapova, P. R. Brink, I. S. Cohen, and S. V. Doronin (2008)
J. Biol. Chem. 283, 13100-13107
   Abstract »    Full Text »    PDF »
The function of coreceptor as a basis for the kinetic dissection of HIV type 1 envelope protein-mediated cell fusion.
M.-P. Chien, S. Jiang, and D.-K. Chang (2008)
FASEB J 22, 1179-1192
   Abstract »    Full Text »    PDF »
Stromal cell-derived factor 1-{alpha} (SDF)-induced human T cell chemotaxis becomes phosphoinositide 3-kinase (PI3K)-independent: role of PKC-{theta}.
N. A. Shahabi, K. McAllen, and B. M. Sharp (2008)
J. Leukoc. Biol. 83, 663-671
   Abstract »    Full Text »    PDF »
Impact of antiretroviral therapy on viral tropism in HIV-infected patients followed longitudinally for over 5 years.
V. Briz, E. Poveda, M. del Mar Gonzalez, L. Martin-Carbonero, R. Gonzalez-Gonzalez, and V. Soriano (2008)
J. Antimicrob. Chemother. 61, 405-410
   Abstract »    Full Text »    PDF »
Mapping of Equine Lentivirus Receptor 1 Residues Critical for Equine Infectious Anemia Virus Envelope Binding.
B. Zhang, C. Sun, S. Jin, M. Cascio, and R. C. Montelaro (2008)
J. Virol. 82, 1204-1213
   Abstract »    Full Text »    PDF »
Effects of Partial Deletions within the Human Immunodeficiency Virus Type 1 V3 Loop on Coreceptor Tropism and Sensitivity to Entry Inhibitors.
K. M. Nolan, A. P. O. Jordan, and J. A. Hoxie (2008)
J. Virol. 82, 664-673
   Abstract »    Full Text »    PDF »
Subtype-Specific Conformational Differences within the V3 Region of Subtype B and Subtype C Human Immunodeficiency Virus Type 1 Env Proteins.
M. B. Patel, N. G. Hoffman, and R. Swanstrom (2008)
J. Virol. 82, 903-916
   Abstract »    Full Text »    PDF »
Modulation of Human Immunodeficiency Virus Type 1 Infectivity through Incorporation of Tetraspanin Proteins.
K. Sato, J. Aoki, N. Misawa, E. Daikoku, K. Sano, Y. Tanaka, and Y. Koyanagi (2008)
J. Virol. 82, 1021-1033
   Abstract »    Full Text »    PDF »
Comparison of Plasma Viremia and Antibody Responses in Macaques Inoculated with Envelope Variants of Single-Cycle Simian Immunodeficiency Virus Differing in Infectivity and Cellular Tropism.
M. Q. DeGottardi, S. K. Lew, M. Piatak Jr., B. Jia, Y. Feng, S. J. Lee, J. M. Brenchley, D. C. Douek, T. Kodama, J. D. Lifson, et al. (2008)
J. Virol. 82, 321-334
   Abstract »    Full Text »    PDF »
A Study of the Coevolutionary Patterns Operating within the env Gene of the HIV-1 Group M Subtypes.
S. A. A. Travers, D. C. Tully, G. P. McCormack, and M. A. Fares (2007)
Mol. Biol. Evol. 24, 2787-2801
   Abstract »    Full Text »    PDF »
Fusion Induced by a Class II Viral Fusion Protein, Semliki Forest Virus E1, Is Dependent on the Voltage of the Target Cell.
R. M. Markosyan, M. Kielian, and F. S. Cohen (2007)
J. Virol. 81, 11218-11225
   Abstract »    Full Text »    PDF »
Crystal Structure and Structural Mechanism of a Novel Anti-Human Immunodeficiency Virus and D-Amino Acid-Containing Chemokine.
D. Liu, N. Madani, Y. Li, R. Cao, W.-T. Choi, S. P. Kawatkar, M. Y. Lim, S. Kumar, C.-Z. Dong, J. Wang, et al. (2007)
J. Virol. 81, 11489-11498
   Abstract »    Full Text »    PDF »
The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization.
R. Lima e Silva, J. Shen, S. F. Hackett, S. Kachi, H. Akiyama, K. Kiuchi, K. Yokoi, M. C. Hatara, T. Lauer, S. Aslam, et al. (2007)
FASEB J 21, 3219-3230
   Abstract »    Full Text »    PDF »
Role of the SDF-1/CXCR4 Axis in the Pathogenesis of Lung Injury and Fibrosis.
J. Xu, A. Mora, H. Shim, A. Stecenko, K. L. Brigham, and M. Rojas (2007)
Am. J. Respir. Cell Mol. Biol. 37, 291-299
   Abstract »    Full Text »    PDF »
Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition.
E. Nilsson, N. Rogers, and M. K Skinner (2007)
Reproduction 134, 209-221
   Abstract »    Full Text »    PDF »
CXC Chemokine Receptor-4 Antagonist Blocks Both Growth of Primary Tumor and Metastasis of Head and Neck Cancer in Xenograft Mouse Models.
Y. Yoon, Z. Liang, X. Zhang, M. Choe, A. Zhu, H. T. Cho, D. M. Shin, M. M. Goodman, Z. Chen, and H. Shim (2007)
Cancer Res. 67, 7518-7524
   Abstract »    Full Text »    PDF »
CCR5{Delta}32 Protein Expression and Stability Are Critical for Resistance to Human Immunodeficiency Virus Type 1 In Vivo.
L. Agrawal, Q. Jin, J. Altenburg, L. Meyer, R. Tubiana, I. Theodorou, and G. Alkhatib (2007)
J. Virol. 81, 8041-8049
   Abstract »    Full Text »    PDF »
Rapamycin Reduces CCR5 Density Levels on CD4 T Cells, and This Effect Results in Potentiation of Enfuvirtide (T-20) against R5 Strains of Human Immunodeficiency Virus Type 1 In Vitro.
A. Heredia, B. Gilliam, O. Latinovic, N. Le, D. Bamba, A. DeVico, G. B. Melikyan, R. C. Gallo, and R. R. Redfield (2007)
Antimicrob. Agents Chemother. 51, 2489-2496
   Abstract »    Full Text »    PDF »
Involvement of an Autocrine Stromal Cell Derived Factor-1/CXCR4 System on the Distant Metastasis of Human Oral Squamous Cell Carcinoma.
D. Uchida, T. Onoue, Y. Tomizuka, N. M. Begum, Y. Miwa, H. Yoshida, and M. Sato (2007)
Mol. Cancer Res. 5, 685-694
   Abstract »    Full Text »    PDF »
A Novel Regulatory Role for Stromal-derived Factor-1 Signaling in Bone Morphogenic Protein-2 Osteogenic Differentiation of Mesenchymal C2C12 Cells.
W. Zhu, O. Boachie-Adjei, B. A. Rawlins, B. Frenkel, A. L. Boskey, L. B. Ivashkiv, and C. P. Blobel (2007)
J. Biol. Chem. 282, 18676-18685
   Abstract »    Full Text »    PDF »
Characterization of Human Immunodeficiency Virus Type 1 Monomeric and Trimeric gp120 Glycoproteins Stabilized in the CD4-Bound State: Antigenicity, Biophysics, and Immunogenicity.
B. Dey, M. Pancera, K. Svehla, Y. Shu, S.-H. Xiang, J. Vainshtein, Y. Li, J. Sodroski, P. D. Kwong, J. R. Mascola, et al. (2007)
J. Virol. 81, 5579-5593
   Abstract »    Full Text »    PDF »
Sphingomyelinase Restricts the Lateral Diffusion of CD4 and Inhibits Human Immunodeficiency Virus Fusion.
C. M. Finnegan, S. S. Rawat, E. H. Cho, D. L. Guiffre, S. Lockett, A. H. Merrill Jr., and R. Blumenthal (2007)
J. Virol. 81, 5294-5304
   Abstract »    Full Text »    PDF »
Dual Effect of AMD3100, a CXCR4 Antagonist, on Bleomycin-Induced Lung Inflammation.
M. Watanabe, W. Matsuyama, Y. Shirahama, H. Mitsuyama, K.-i. Oonakahara, S. Noma, I. Higashimoto, M. Osame, and K. Arimura (2007)
J. Immunol. 178, 5888-5898
   Abstract »    Full Text »    PDF »
Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor.
S. Hatse, D. Huskens, K. Princen, K. Vermeire, G. J. Bridger, E. De Clercq, M. M. Rosenkilde, T. W. Schwartz, and D. Schols (2007)
J. Virol. 81, 3632-3639
   Abstract »    Full Text »    PDF »
The Second Extracellular Loop of CCR5 Contains the Dominant Epitopes for Highly Potent Anti-Human Immunodeficiency Virus Monoclonal Antibodies.
J. Zhang, E. Rao, M. Dioszegi, R. Kondru, A. DeRosier, E. Chan, S. Schwoerer, N. Cammack, M. Brandt, S. Sankuratri, et al. (2007)
Antimicrob. Agents Chemother. 51, 1386-1397
   Abstract »    Full Text »    PDF »
Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.
J. R. Trujillo, R. Rogers, R. M. Molina, F. Dangond, M. F. McLane, M. Essex, and J. D. Brain (2007)
PNAS 104, 5097-5102
   Abstract »    Full Text »    PDF »
Chemokines and chemokine receptors in the brain: implication in neuroendocrine regulation.
C. Callewaere, G. Banisadr, W. Rostene, and S. M. Parsadaniantz (2007)
J. Mol. Endocrinol. 38, 355-363
   Abstract »    Full Text »    PDF »
Multiple actions of the chemokine stromal cell-derived factor-1{alpha} on neuronal activity.
A. Guyon and J.-L. Nahon (2007)
J. Mol. Endocrinol. 38, 365-376
   Abstract »    Full Text »    PDF »
Role of stromal cell-derived factor 1 (SDF1/CXCL12) in regulating anterior pituitary function.
F. Barbieri, A. Bajetto, C. Porcile, A. Pattarozzi, G. Schettini, and T. Florio (2007)
J. Mol. Endocrinol. 38, 383-389
   Abstract »    Full Text »    PDF »
DEC-205-Mediated Internalization of HIV-1 Results in the Establishment of Silent Infection in Renal Tubular Cells.
I. Hatsukari, P. Singh, N. Hitosugi, D. Messmer, E. Valderrama, S. Teichberg, W. Chaung, E. Gross, H. Schmidtmayerova, and P. C. Singhal (2007)
J. Am. Soc. Nephrol. 18, 780-787
   Abstract »    Full Text »    PDF »
Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants.
V. Svetic, G. E. Hollway, S. Elworthy, T. R. Chipperfield, C. Davison, R. J. Adams, J. S. Eisen, P. W. Ingham, P. D. Currie, and R. N. Kelsh (2007)
Development 134, 1011-1022
   Abstract »    Full Text »    PDF »
A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients.
A. Vasilescu, Y. Terashima, M. Enomoto, S. Heath, V. Poonpiriya, H. Gatanaga, H. Do, G. Diop, T. Hirtzig, P. Auewarakul, et al. (2007)
PNAS 104, 3354-3359
   Abstract »    Full Text »    PDF »
Physiological Levels of Virion-Associated Human Immunodeficiency Virus Type 1 Envelope Induce Coreceptor-Dependent Calcium Flux.
M. Melar, D. E. Ott, and T. J. Hope (2007)
J. Virol. 81, 1773-1785
   Abstract »    Full Text »    PDF »
Development and Characterization of a Novel Single-Cycle Recombinant-Virus Assay To Determine Human Immunodeficiency Virus Type 1 Coreceptor Tropism.
J. M. Whitcomb, W. Huang, S. Fransen, K. Limoli, J. Toma, T. Wrin, C. Chappey, L. D. B. Kiss, E. E. Paxinos, and C. J. Petropoulos (2007)
Antimicrob. Agents Chemother. 51, 566-575
   Abstract »    Full Text »    PDF »
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling.
J.-C. Twizere, J.-Y. Springael, M. Boxus, A. Burny, F. Dequiedt, J.-F. Dewulf, J. Duchateau, D. Portetelle, P. Urbain, C. V. Lint, et al. (2007)
Blood 109, 1051-1060
   Abstract »    Full Text »    PDF »
Inhibition of Human Immunodeficiency Virus Envelope Glycoprotein- Mediated Single Cell Lysis by Low-Molecular-Weight Antagonists of Viral Entry.
N. Madani, A. M. Hubicki, A. L. Perdigoto, M. Springer, and J. Sodroski (2007)
J. Virol. 81, 532-538
   Abstract »    Full Text »    PDF »
Nuclear Import of the Preintegration Complex Is Blocked upon Infection by Human Immunodeficiency Virus Type 1 in Mouse Cells.
N. Tsurutani, J. Yasuda, N. Yamamoto, B.-I. Choi, M. Kadoki, and Y. Iwakura (2007)
J. Virol. 81, 677-688
   Abstract »    Full Text »    PDF »
Increased Neutralization Sensitivity of Recently Emerged CXCR4-Using Human Immunodeficiency Virus Type 1 Strains Compared to Coexisting CCR5-Using Variants from the Same Patient.
E. M. Bunnik, E. D. Quakkelaar, A. C. van Nuenen, B. Boeser-Nunnink, and H. Schuitemaker (2007)
J. Virol. 81, 525-531
   Abstract »    Full Text »    PDF »
Antiviral activity obtained from aqueous extracts of the Chilean soapbark tree (Quillaja saponaria Molina).
M. R. Roner, J. Sprayberry, M. Spinks, and S. Dhanji (2007)
J. Gen. Virol. 88, 275-285
   Abstract »    Full Text »    PDF »
Impact of Natural Polymorphism within the gp41 Cytoplasmic Tail of Human Immunodeficiency Virus Type 1 on the Intracellular Distribution of Envelope Glycoproteins and Viral Assembly.
M. Lambele, B. Labrosse, E. Roch, A. Moreau, B. Verrier, F. Barin, P. Roingeard, F. Mammano, and D. Brand (2007)
J. Virol. 81, 125-140
   Abstract »    Full Text »    PDF »
Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists.
T. Kenakin, S. Jenkinson, and C. Watson (2006)
J. Pharmacol. Exp. Ther. 319, 710-723
   Abstract »    Full Text »    PDF »
HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes.
M. M. Goodenow and R. G. Collman (2006)
J. Leukoc. Biol. 80, 965-972
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Persistence and Production in T-Cell Development.
K. B. Gurney and C. H. Uittenbogaart (2006)
Clin. Vaccine Immunol. 13, 1237-1245
   Abstract »    Full Text »    PDF »
A Tyrosine-sulfated Peptide Derived from the Heavy-chain CDR3 Region of an HIV-1-neutralizing Antibody Binds gp120 and Inhibits HIV-1 Infection.
T. Dorfman, M. J. Moore, A. C. Guth, H. Choe, and M. Farzan (2006)
J. Biol. Chem. 281, 28529-28535
   Abstract »    Full Text »    PDF »
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.
J. M. Burns, B. C. Summers, Y. Wang, A. Melikian, R. Berahovich, Z. Miao, M. E. T. Penfold, M. J. Sunshine, D. R. Littman, C. J. Kuo, et al. (2006)
J. Exp. Med. 203, 2201-2213
   Abstract »    Full Text »    PDF »
Structural Basis for the Interaction of CCR5 with a Small Molecule, Functionally Selective CCR5 Agonist..
Y. Saita, E. Kodama, M. Orita, M. Kondo, T. Miyazaki, K. Sudo, K. Kajiwara, M. Matsuoka, and Y. Shimizu (2006)
J. Immunol. 177, 3116-3122
   Abstract »    Full Text »    PDF »
Biology of CCR5 and its role in HIV infection and treatment..
M. M. Lederman, A. Penn-Nicholson, M. Cho, and D. Mosier (2006)
JAMA 296, 815-826
   Abstract »    Full Text »    PDF »
AMD3465, a Novel CXCR4 Receptor Antagonist, Abrogates Schistosomal Antigen-Elicited (Type-2) Pulmonary Granuloma Formation.
J. S. Hu, C. M. Freeman, V. R. Stolberg, B. C. Chiu, G. J. Bridger, S. P. Fricker, N. W. Lukacs, and S. W. Chensue (2006)
Am. J. Pathol. 169, 424-432
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-1 Produced by Human CXCL12-Stimulated Natural Killer Cells.
S. Goda, H. Inoue, H. Umehara, M. Miyaji, Y. Nagano, N. Harakawa, H. Imai, P. Lee, J. B. MaCarthy, T. Ikeo, et al. (2006)
Am. J. Pathol. 169, 445-458
   Abstract »    Full Text »    PDF »
G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells.
H. K. Kim, M. De La Luz Sierra, C. K. Williams, A. V. Gulino, and G. Tosato (2006)
Blood 108, 812-820
   Abstract »    Full Text »    PDF »
Characterization of the Multiple Conformational States of Free Monomeric and Trimeric Human Immunodeficiency Virus Envelope Glycoproteins after Fixation by Cross-Linker.
W. Yuan, J. Bazick, and J. Sodroski (2006)
J. Virol. 80, 6725-6737
   Abstract »    Full Text »    PDF »
Novel Activities of Cyclophilin A and Cyclosporin A during HIV-1 Infection of Primary Lymphocytes and Macrophages.
M. Saini and M. J. Potash (2006)
J. Immunol. 177, 443-449
   Abstract »    Full Text »    PDF »
Subunit Stoichiometry of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers during Virus Entry into Host Cells.
X. Yang, S. Kurteva, X. Ren, S. Lee, and J. Sodroski (2006)
J. Virol. 80, 4388-4395
   Abstract »    Full Text »    PDF »
Role of Human {beta}-defensins in HIV Infection.
A. Weinberg, M.E. Quinones-Mateu, and M.M. Lederman (2006)
Advances in Dental Research 19, 42-48
   Abstract »    Full Text »    PDF »
The 73-kDa Heat Shock Cognate Protein Is a CXCR4 Binding Protein that Regulates the Receptor Endocytosis and the Receptor-Mediated Chemotaxis.
Y. Ding, M. Li, J. Zhang, N. Li, Z. Xia, Y. Hu, S. Wang, and G.-H. Fan (2006)
Mol. Pharmacol. 69, 1269-1279
   Abstract »    Full Text »    PDF »
Fusoselect: cell-cell fusion activity engineered by directed evolution of a retroviral glycoprotein.
C. A. Merten, J. Stitz, G. Braun, J. Medvedovska, K. Cichutek, and C. J. Buchholz (2006)
Nucleic Acids Res. 34, e41
   Abstract »    Full Text »    PDF »
R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells.
C. Cicala, J. Arthos, E. Martinelli, N. Censoplano, C. C. Cruz, E. Chung, S. M. Selig, D. Van Ryk, J. Yang, S. Jagannatha, et al. (2006)
PNAS 103, 3746-3751
   Abstract »    Full Text »    PDF »
Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): evolution of coreceptor use varies with pathogenic outcome..
A. Lauren, D. Vodros, R. Thorstensson, and E. M. Fenyo (2006)
J. Gen. Virol. 87, 581-594
   Abstract »    Full Text »    PDF »
A Mutation in the Human Immunodeficiency Virus Type 1 Gag Protein Destabilizes the Interaction of the Envelope Protein Subunits gp120 and gp41.
M. R. Davis, J. Jiang, J. Zhou, E. O. Freed, and C. Aiken (2006)
J. Virol. 80, 2405-2417
   Abstract »    Full Text »    PDF »
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.
J. A. Burger and T. J. Kipps (2006)
Blood 107, 1761-1767
   Abstract »    Full Text »    PDF »
Functional Analysis of Hepatitis C Virus Envelope Proteins, Using a Cell-Cell Fusion Assay.
M. Kobayashi, M. C. Bennett, T. Bercot, and I. R. Singh (2006)
J. Virol. 80, 1817-1825
   Abstract »    Full Text »    PDF »
Human immunodeficiency virus types 1 and 2 have different replication kinetics in human primary macrophage culture.
D. Marchant, S. J. D. Neil, and A. McKnight (2006)
J. Gen. Virol. 87, 411-418
   Abstract »    Full Text »    PDF »
Characterization of Antibody Responses Elicited by Human Immunodeficiency Virus Type 1 Primary Isolate Trimeric and Monomeric Envelope Glycoproteins in Selected Adjuvants.
Y. Li, K. Svehla, N. L. Mathy, G. Voss, J. R. Mascola, and R. Wyatt (2006)
J. Virol. 80, 1414-1426
   Abstract »    Full Text »    PDF »
Chemokine Stromal Cell-Derived Factor 1{alpha} Induces Proliferation and Growth Hormone Release in GH4C1 Rat Pituitary Adenoma Cell Line through Multiple Intracellular Signals.
T. Florio, S. Casagrande, F. Diana, A. Bajetto, C. Porcile, G. Zona, S. Thellung, S. Arena, A. Pattarozzi, A. Corsaro, et al. (2006)
Mol. Pharmacol. 69, 539-546
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Coreceptor Switching: V1/V2 Gain-of-Fitness Mutations Compensate for V3 Loss-of-Fitness Mutations.
C. Pastore, R. Nedellec, A. Ramos, S. Pontow, L. Ratner, and D. E. Mosier (2006)
J. Virol. 80, 750-758
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)