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Science 3 May 1996:
Vol. 272. no. 5262, pp. 735 - 738
DOI: 10.1126/science.272.5262.735
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Reports

The Cytolytic P2Z Receptor for Extracellular ATP Identified as a P2X Receptor (P2X7)

A. Surprenant, * F. Rassendren, E. Kawashima, R. A. North, G. Buell

The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Other ATP-gated channels, the P2X receptors, are permeable only to small cations. Here, an ATP receptor, the P2X7 receptor, was cloned from rat brain and exhibited both these properties. This protein is homologous to other P2X receptors but has a unique carboxyl-terminal domain that was required for the lytic actions of ATP. Thus, the P2X7 (or P2Z) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

Glaxo Institute for Molecular Biology, Plan-les-Ouates, 1228 Geneva, Switzerland.
* To whom correspondence should be addressed. E-mail: AS28995{at}ggr.co.uk


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J. Immunol. 174, 3880-3890
   Abstract »    Full Text »    PDF »
CD38 Controls ADP-Ribosyltransferase-2-Catalyzed ADP-Ribosylation of T Cell Surface Proteins.
C. Krebs, S. Adriouch, F. Braasch, W. Koestner, E. H. Leiter, M. Seman, F. E. Lund, N. Oppenheimer, F. Haag, and F. Koch-Nolte (2005)
J. Immunol. 174, 3298-3305
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Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels.
T. Sugiyama, H. Kawamura, S. Yamanishi, M. Kobayashi, K. Katsumura, and D. G. Puro (2005)
Am J Physiol Cell Physiol 288, C568-C576
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Contribution of Transmembrane Regions to ATP-gated P2X2 Channel Permeability Dynamics.
B. S. Khakh and T. M. Egan (2005)
J. Biol. Chem. 280, 6118-6129
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Large pore formation uniquely associated with P2X7 purinergic receptor channels. Focus on "Are second messengers crucial for opening the pore associated with P2X7 receptor?".
L. Liang and E. M. Schwiebert (2005)
Am J Physiol Cell Physiol 288, C240-C242
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Are second messengers crucial for opening the pore associated with P2X7 receptor?.
R. X. Faria, F. P. DeFarias, and L. A. Alves (2005)
Am J Physiol Cell Physiol 288, C260-C271
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Depression of cell metabolism and proliferation by membrane-permeable and -impermeable modulators: role for AMP-to-ATP ratio.
M. A. Menze, M. J. Clavenna, and S. C. Hand (2005)
Am J Physiol Regulatory Integrative Comp Physiol 288, R501-R510
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Involvement of Chloride in Apoptotic Cell Death Induced by Activation of ATP-sensitive P2X7 Purinoceptor.
M. Tsukimoto, H. Harada, A. Ikari, and K. Takagi (2005)
J. Biol. Chem. 280, 2653-2658
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Epidermal Growth Factor Facilitates Epinephrine Inhibition of P2X7-Receptor-Mediated Pore Formation and Apoptosis: A Novel Signaling Network.
L. Wang, Y.-H. Feng, and G. I. Gorodeski (2005)
Endocrinology 146, 164-174
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Time-Resolved Measurement of State-Specific P2X2 Ion Channel Cytosolic Gating Motions.
J. A. Fisher, G. Girdler, and B. S. Khakh (2004)
J. Neurosci. 24, 10475-10487
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Extracellular ATP Increases Cation Fluxes in Human Erythrocytes by Activation of the P2X7 Receptor.
R. Sluyter, A. N. Shemon, J. A. Barden, and J. S. Wiley (2004)
J. Biol. Chem. 279, 44749-44755
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The Antibiotic Polymyxin B Modulates P2X7 Receptor Function.
D. Ferrari, C. Pizzirani, E. Adinolfi, S. Forchap, B. Sitta, L. Turchet, S. Falzoni, M. Minelli, R. Baricordi, and F. Di Virgilio (2004)
J. Immunol. 173, 4652-4660
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ATP-Induced Non-Neuronal Cell Permeabilization in the Rat Inner Retina.
B. Innocenti, S. Pfeiffer, E. Zrenner, K. Kohler, and E. Guenther (2004)
J. Neurosci. 24, 8577-8583
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Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors.
F. S. A. Fortes, I. L. Pecora, P. M. Persechini, S. Hurtado, V. Costa, R. Coutinho-Silva, M. B. M. Braga, F. C. Silva-Filho, R. C. Bisaggio, F. P. de Farias, et al. (2004)
J. Cell Sci. 117, 4717-4726
   Abstract »    Full Text »    PDF »
ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells.
J. F. Hiken and T. H. Steinberg (2004)
Am J Physiol Cell Physiol 287, C403-C412
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An Arg307 to Gln Polymorphism within the ATP-binding Site Causes Loss of Function of the Human P2X7 Receptor.
B. J. Gu, R. Sluyter, K. K. Skarratt, A. N. Shemon, L.-P. Dao-Ung, S. J. Fuller, J. A. Barden, A. L. Clarke, S. Petrou, and J. S. Wiley (2004)
J. Biol. Chem. 279, 31287-31295
   Abstract »    Full Text »    PDF »
Density-dependent changes of the pore properties of the P2X2 receptor channel.
Y. Fujiwara and Y. Kubo (2004)
J. Physiol. 558, 31-43
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Enhanced P2X7 Activity in Human Fibroblasts From Diabetic Patients: A Possible Pathogenetic Mechanism for Vascular Damage in Diabetes.
A. Solini, P. Chiozzi, A. Morelli, E. Adinolfi, R. Rizzo, O. R. Baricordi, and F. Di Virgilio (2004)
Arterioscler Thromb Vasc Biol 24, 1240-1245
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The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho.
Z. A. Pfeiffer, M. Aga, U. Prabhu, J. J. Watters, D. J. Hall, and P. J. Bertics (2004)
J. Leukoc. Biol. 75, 1173-1182
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Involvement of Sodium in Early Phosphatidylserine Exposure and Phospholipid Scrambling Induced by P2X7 Purinoceptor Activation in Thymocytes.
M.-P. Courageot, S. Lepine, M. Hours, F. Giraud, and J.-C. Sulpice (2004)
J. Biol. Chem. 279, 21815-21823
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The Pro-451 to Leu Polymorphism within the C-terminal Tail of P2X7 Receptor Impairs Cell Death but Not Phospholipase D Activation in Murine Thymocytes.
H. Le Stunff, R. Auger, J. Kanellopoulos, and M.-N. Raymond (2004)
J. Biol. Chem. 279, 16918-16926
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Functional Regulation of P2X6 Receptors by N-Linked Glycosylation: Identification of a Novel {alpha}{beta}-Methylene ATP-Sensitive Phenotype.
C. A. Jones, C. Vial, L. A. Sellers, P. P. A. Humphrey, R. J. Evans, and I. P. Chessell (2004)
Mol. Pharmacol. 65, 979-985
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Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1{beta} Release from Human Monocytes.
R. Sluyter, A. N. Shemon, and J. S. Wiley (2004)
J. Immunol. 172, 3399-3405
   Abstract »    Full Text »    PDF »


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