Science 3 May 1996: Vol. 272. no. 5262, pp. 676 - 680 DOI: 10.1126/science.272.5262.676

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Articles

Extracellular Chloride Regulates the Epithelial Sodium Channel.

D. M. Collier and P. M. Snyder (2009)
J. Biol. Chem. 284, 29320-29325
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Down-Regulating Destruction: Phosphorylation Regulates the E3 Ubiquitin Ligase Nedd4-2.

P. M. Snyder (2009)
Science Signaling 2, pe41
 |  Abstract »  |  Full Text »  |  PDF »

Hypertension in mice lacking the CXCR3 chemokine receptor.

H.-H. Hsu, K. Duning, H. H. Meyer, M. Stolting, T. Weide, S. Kreusser, T. van Le, C. Gerard, R. Telgmann, S.-M. Brand-Herrmann, et al. (2009)
Am J Physiol Renal Physiol 296, F780-F789
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Protons Regulate Human ENaC by Modulating Na+ Self-inhibition.

D. M. Collier and P. M. Snyder (2009)
J. Biol. Chem. 284, 792-798
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Genetic Effect on Blood Pressure Is Modulated by Age: The Hypertension Genetic Epidemiology Network Study.

G. Shi, C. C. Gu, A. T. Kraja, D. K. Arnett, R. H. Myers, J. S. Pankow, S. C. Hunt, and D. C. Rao (2009)
Hypertension 53, 35-41
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Ambulatory Blood Pressure Is Associated With Polymorphic Variation in P2X Receptor Genes.

J. Palomino-Doza, T. J. Rahman, P. J. Avery, B. M. Mayosi, M. Farrall, H. Watkins, C. R.W. Edwards, and B. Keavney (2008)
Hypertension 52, 980-985
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Intracellular Sodium Regulates Proteolytic Activation of the Epithelial Sodium Channel.

K. K. Knight, D. M. Wentzlaff, and P. M. Snyder (2008)
J. Biol. Chem. 283, 27477-27482
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Nedd4-2 Induces Endocytosis and Degradation of Proteolytically Cleaved Epithelial Na+ Channels.

R. Kabra, K. K. Knight, R. Zhou, and P. M. Snyder (2008)
J. Biol. Chem. 283, 6033-6039
 |  Abstract »  |  Full Text »  |  PDF »

Salt-Sensitive Blood Pressure in Mice With Increased Expression of Aldosterone Synthase.

N. Makhanova, J. Hagaman, H.-S. Kim, and O. Smithies (2008)
Hypertension 51, 134-140
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Epithelial Sodium Channel Exit from the Endoplasmic Reticulum Is Regulated by a Signal within the Carboxyl Cytoplasmic Domain of the {alpha} Subunit.

G. M. Mueller, O. B. Kashlan, J. B. Bruns, A. B. Maarouf, M. Aridor, T. R. Kleyman, and R. P. Hughey (2007)
J. Biol. Chem. 282, 33475-33483
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Functional significance of channels and transporters expressed in the inner ear and kidney.

F. Lang, V. Vallon, M. Knipper, and P. Wangemann (2007)
Am J Physiol Cell Physiol 293, C1187-C1208
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Nedd4-2 Catalyzes Ubiquitination and Degradation of Cell Surface ENaC.

R. Zhou, S. V. Patel, and P. M. Snyder (2007)
J. Biol. Chem. 282, 20207-20212
 |  Abstract »  |  Full Text »  |  PDF »

Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group.

D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. (2007)
Circulation 115, 2878-2901
 |  Abstract »  |  Full Text »  |  PDF »

Blood pressure is the most important cause of death and disability in the world.

F. J. He and G. A. MacGregor (2007)
Eur. Heart J. Suppl. 9, B23-B28
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Dissection of a Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 and Gene Expression Analysis Identifies SPON1 As a Novel Candidate Hypertension Gene.

J.-R. Clemitson, R. J. Dixon, S. Haines, A. J. Bingham, B. R. Patel, L. Hall, M. Lo, J. Sassard, F. J. Charchar, and N. J. Samani (2007)
Circ. Res. 100, 992-999
 |  Abstract »  |  Full Text »  |  PDF »

The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel.

A. Bengrine, J. Li, and M. S. Awayda (2007)
FASEB J 21, 1189-1201
 |  Abstract »  |  Full Text »  |  PDF »

Resistance of mice lacking the serum- and glucocorticoid-inducible kinase SGK1 against salt-sensitive hypertension induced by a high-fat diet.

D. Y. Huang, K. M. Boini, H. Osswald, B. Friedrich, F. Artunc, S. Ullrich, J. Rajamanickam, M. Palmada, P. Wulff, D. Kuhl, et al. (2006)
Am J Physiol Renal Physiol 291, F1264-F1273
 |  Abstract »  |  Full Text »  |  PDF »

Importance of Salt in Determining Blood Pressure in Children: Meta-Analysis of Controlled Trials.

F. J. He and G. A. MacGregor (2006)
Hypertension 48, 861-869
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Nephron Number, Uric Acid, and Renal Microvascular Disease in the Pathogenesis of Essential Hypertension.

D. I. Feig, B. Rodriguez-Iturbe, T. Nakagawa, and R. J. Johnson (2006)
Hypertension 48, 25-26
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Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats.

J. Song, X. Hu, S. Riazi, S. Tiwari, J. B. Wade, and C. A. Ecelbarger (2006)
Am J Physiol Renal Physiol 290, F1055-F1064
 |  Abstract »  |  Full Text »  |  PDF »

Blunted hypertensive effect of combined fructose and high-salt diet in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase SGK1.

D. Y. Huang, K. M. Boini, B. Friedrich, M. Metzger, L. Just, H. Osswald, P. Wulff, D. Kuhl, V. Vallon, and F. Lang (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R935-R944
 |  Abstract »  |  Full Text »  |  PDF »

Dietary salt and hypertension: new molecular targets add more spice.

R. A. Khalil (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R509-R513
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Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.

P. Ferrari, M. Ferrandi, G. Valentini, and G. Bianchi (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R529-R535
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Early Phenotypic Changes in Hypertension: A Role for the Autonomic Nervous System and Heredity.

E. O. Lillie and D. T. O'Connor (2006)
Hypertension 47, 331-333
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Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.

K. K. Knight, D. R. Olson, R. Zhou, and P. M. Snyder (2006)
PNAS 103, 2805-2808
 |  Abstract »  |  Full Text »  |  PDF »

Central Role for ENaC in Development of Hypertension.

J. H. Pratt (2005)
J. Am. Soc. Nephrol. 16, 3154-3159
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Association of NEDD4L Ubiquitin Ligase With Essential Hypertension.

C. J. Russo, E. Melista, J. Cui, A. L. DeStefano, G. L. Bakris, A. J. Manolis, H. Gavras, and C. T. Baldwin (2005)
Hypertension 46, 488-491
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Improvement in Blood Pressure With Inhibition of the Epithelial Sodium Channel in Blacks With Hypertension.

C. Saha, G. J. Eckert, W. T. Ambrosius, T.-Y. Chun, M. A. Wagner, Q. Zhao, and J. H. Pratt (2005)
Hypertension 46, 481-487
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin-converting enzyme (ACE) haplotypes and cyclosporine A (CsA) response: a model of the complex relationship between ACE quantitative trait locus and pathological phenotypes.

P. Catarsi, R. Ravazzolo, F. Emma, D. Fruci, L. Finos, A. Frau, G. Morreale, A. Carrea, and G. M. Ghiggeri (2005)
Hum. Mol. Genet. 14, 2357-2367
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Modest Salt Reduction Lowers Blood Pressure in Isolated Systolic Hypertension and Combined Hypertension.

F. J. He, N. D. Markandu, and G. A. MacGregor (2005)
Hypertension 46, 66-70
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Overexpression of the Epithelial Na+ Channel {gamma} Subunit in Collecting Duct Cells: INTERACTIONS OF LIDDLE'S MUTATIONS AND STEROIDS ON EXPRESSION AND FUNCTION.

K. A. Volk, R. F. Husted, R. D. Sigmund, and J. B. Stokes (2005)
J. Biol. Chem. 280, 18348-18354
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Subtle Renal Injury Is Likely a Common Mechanism for Salt-Sensitive Essential Hypertension.

R. J. Johnson, B. Rodriguez-Iturbe, T. Nakagawa, D.-H. Kang, D. I. Feig, and J. Herrera-Acosta (2005)
Hypertension 45, 326-330
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Plasma Sodium: Ignored and Underestimated.

F. J. He, N. D. Markandu, G. A. Sagnella, H. E. de Wardener, and G. A. MacGregor (2005)
Hypertension 45, 98-102
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Surfing the lipid bilayer: how basolateral insulin receptors regulate Na+ channels in the apical cell membrane. Focus on "Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na+ channels".

F. Lang (2004)
Am J Physiol Cell Physiol 287, C1539-C1540
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Blood Pressure and the Cystic Fibrosis Gene: Evidence for Lower Pressure Rises With Age in Female Carriers.

M. Super, A. Irtiza-Ali, S. A. Roberts, M. Schwarz, M. Young, A. Smith, T. Roberts, J. Hinks, and A. Heagerty (2004)
Hypertension 44, 878-883
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cAMP and Serum and Glucocorticoid-inducible Kinase (SGK) Regulate the Epithelial Na+ Channel through Convergent Phosphorylation of Nedd4-2.

P. M. Snyder, D. R. Olson, R. Kabra, R. Zhou, and J. C. Steines (2004)
J. Biol. Chem. 279, 45753-45758
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{alpha}-Adducin Gly460Trp Polymorphism and Renal Hemodynamics in Essential Hypertension.

E. Beeks, M. M. van der Klauw, A. A. Kroon, W. Spiering, M. J.M.J. Fuss-Lejeune, and P. W. de Leeuw (2004)
Hypertension 44, 419-423
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Genetic Basis of Atherosclerosis: Part I: New Genes and Pathways.

A. J. Lusis, A. M. Fogelman, and G. C. Fonarow (2004)
Circulation 110, 1868-1873
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Tree-structured supervised learning and the genetics of hypertension.

J. Huang, A. Lin, B. Narasimhan, T. Quertermous, C. A. Hsiung, L.-T. Ho, J. S. Grove, M. Olivier, K. Ranade, N. J. Risch, et al. (2004)
PNAS 101, 10529-10534
 |  Abstract »  |  Full Text »  |  PDF »

Serum Aldosterone and the Incidence of Hypertension in Nonhypertensive Persons.

R. S. Vasan, J. C. Evans, M. G. Larson, P. W.F. Wilson, J. B. Meigs, N. Rifai, E. J. Benjamin, and D. Levy (2004)
N. Engl. J. Med. 351, 33-41
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Activating Mutation of the Renal Epithelial Chloride Channel ClC-Kb Predisposing to Hypertension.

N. Jeck, S. Waldegger, A. Lampert, C. Boehmer, P. Waldegger, P. A. Lang, B. Wissinger, B. Friedrich, T. Risler, R. Moehle, et al. (2004)
Hypertension 43, 1175-1181
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Relative Contribution of Nedd4 and Nedd4-2 to ENaC Regulation in Epithelia Determined by RNA Interference.

P. M. Snyder, J. C. Steines, and D. R. Olson (2004)
J. Biol. Chem. 279, 5042-5046
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Association Between Physical Activity and Blood Pressure Is Modified by Variants in the G-Protein Coupled Receptor 10.

P. W. Franks, S. Bhattacharyya, J.'a. Luan, C. Montague, J. Brennand, B. Challis, S. Brage, U. Ekelund, R. P.S. Middelberg, S. O'Rahilly, et al. (2004)
Hypertension 43, 224-228
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How Far Should Salt Intake Be Reduced?.

F. J. He and G. A. MacGregor (2003)
Hypertension 42, 1093-1099
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Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin.

M. Auberson, N. Hoffmann-Pochon, A. Vandewalle, S. Kellenberger, and L. Schild (2003)
Am J Physiol Renal Physiol 285, F459-F471
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Minireview: Computer Simulations of Blood Pressure Regulation by the Renin-Angiotensin System.

N. Takahashi, J. R. Hagaman, H.-S. Kim, and O. Smithies (2003)
Endocrinology 144, 2184-2190
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Evaluating the Context-Dependent Effect of Family History of Stroke in a Genome Scan for Hypertension.

A. C. Morrison, A. Brown, S. L.R. Kardia, S. T. Turner, and E. Boerwinkle (2003)
Stroke 34, 1170-1175
 |  Abstract »  |  Full Text »  |  PDF »

Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats.

C. Wang, J. Chao, and L. Chao (2003)
Am J Physiol Regulatory Integrative Comp Physiol 284, R1031-R1036
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Racial Difference in the Activity of the Amiloride-Sensitive Epithelial Sodium Channel.

J. H. Pratt, W. T. Ambrosius, R. Agarwal, G. J. Eckert, and S. Newman (2002)
Hypertension 40, 903-908
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Genetics of Essential Hypertension: From Families to Genes.

C. Barlassina, C. Lanzani, P. Manunta, and G. Bianchi (2002)
J. Am. Soc. Nephrol. 13, S155-164
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Identification of Hypertension-Related QTLs in African American Sib Pairs.

T. A. Kotchen, U. Broeckel, C. E. Grim, P. Hamet, H. Jacob, M. L. Kaldunski, J. M. Kotchen, N. J. Schork, P. J. Tonellato, and A. W. Cowley Jr (2002)
Hypertension 40, 634-639
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Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na+ channel.

F. J. McDonald, A. H. Western, J. D. McNeil, B. C. Thomas, D. R. Olson, and P. M. Snyder (2002)
Am J Physiol Renal Physiol 283, F431-F436
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Chronic V2 Vasopressin Receptor Stimulation Increases Basal Blood Pressure and Exacerbates Deoxycorticosterone Acetate-Salt Hypertension.

S. Fernandes, P. Bruneval, A. Hagege, D. Heudes, S. Ghostine, and N. Bouby (2002)
Endocrinology 143, 2759-2766
 |  Abstract »  |  Full Text »  |  PDF »

Diuretic Therapy, the {alpha}-Adducin Gene Variant, and the Risk of Myocardial Infarction or Stroke in Persons With Treated Hypertension.

B. M. Psaty, N. L. Smith, S. R. Heckbert, H. L. Vos, R. N. Lemaitre, A. P. Reiner, D. S. Siscovick, J. Bis, T. Lumley, W. T. Longstreth Jr, et al. (2002)
JAMA 287, 1680-1689
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The Epithelial Na+ Channel: Cell Surface Insertion and Retrieval in Na+ Homeostasis and Hypertension.

P. M. Snyder (2002)
Endocr. Rev. 23, 258-275
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Human Cortical Distal Nephron: Distribution of Electrolyte and Water Transport Pathways.

H. L. Biner, M.-P. Arpin-Bott, J. Loffing, X. Wang, M. Knepper, S. C. Hebert, and B. Kaissling (2002)
J. Am. Soc. Nephrol. 13, 836-847
 |  Abstract »  |  Full Text »  |  PDF »

Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension.

R. J. Johnson, J. Herrera-Acosta, G. F. Schreiner, and B. Rodriguez-Iturbe (2002)
N. Engl. J. Med. 346, 913-923
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Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL/6 mice.

R. Gros, R. Van Wert, X. You, E. Thorin, and M. Husain (2002)
Am J Physiol Heart Circ Physiol 282, H380-H388
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Blood Pressure Responses to Small Doses of Amiloride and Spironolactone in Normotensive Subjects.

J. H. Pratt, G. J. Eckert, S. Newman, and W. T. Ambrosius (2001)
Hypertension 38, 1124-1129
 |  Abstract »  |  Full Text »  |  PDF »

Chronic Exposure to Vasopressin Upregulates ENaC and Sodium Transport in the Rat Renal Collecting Duct and Lung.

C. Nicco, M. Wittner, A. DiStefano, S. Jounier, L. Bankir, and N. Bouby (2001)
Hypertension 38, 1143-1149
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Basis of Salt Sensitivity in Human Hypertension: Evaluation of Renin-Angiotensin-Aldosterone System Gene Polymorphisms.

E. Poch, D. Gonzalez, V. Giner, E. Bragulat, A. Coca, and A. de la Sierra (2001)
Hypertension 38, 1204-1209
 |  Abstract »  |  Full Text »  |  PDF »

Genetic variation in aldosterone synthase predicts plasma glucose levels.

K. Ranade, K. D. Wu, N. Risch, M. Olivier, D. Pei, C.-F. Hsiao, L.-M. Chuang, L.-T. Ho, E. Jorgenson, R. Pesich, et al. (2001)
PNAS
 |  Abstract »  |  Full Text »  |  PDF »

Impaired renal D1-like and D2-like dopamine receptor interaction in the spontaneously hypertensive rat.

C. A. Ladines, C. Zeng, L. D. Asico, X. Sun, F. Pocchiari, C. Semeraro, J. Pisegna, S. Wank, I. Yamaguchi, G. M. Eisner, et al. (2001)
Am J Physiol Regulatory Integrative Comp Physiol 281, R1071-R1078
 |  Abstract »  |  Full Text »  |  PDF »

Genome Scan for Blood Pressure in Dutch Dyslipidemic Families Reveals Linkage to a Locus on Chromosome 4p.

H. Allayee, T. W.A. de Bruin, K. Michelle Dominguez, L. S.-C. Cheng, E. Ipp, R. M. Cantor, K. L. Krass, E. T.P. Keulen, B. E. Aouizerat, A. J. Lusis, et al. (2001)
Hypertension 38, 773-778
 |  Abstract »  |  Full Text »  |  PDF »

Genetic variation in the human urea transporter-2 is associated with variation in blood pressure.

K. Ranade, K.-D. Wu, C.-M. Hwu, C.-T. Ting, D. Pei, R. Pesich, J. Hebert, Y.-D. I. Chen, R. Pratt, R. Olshen, et al. (2001)
Hum. Mol. Genet. 10, 2157-2164
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Gene Therapy for Hypertension: The Preclinical Data.

M. I. Phillips (2001)
Hypertension 38, 543-548
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Endothelin as a natriuretic hormone: the case for a paracrine action mediated by nitric oxide.

Y. Kotelevtsev and D. J Webb (2001)
Cardiovasc Res 51, 481-488
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Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model.

C. L. Welch, S. Bretschger, N. Latib, M. Bezouevski, Y. Guo, N. Pleskac, C.-P. Liang, C. Barlow, H. Dansky, J. L. Breslow, et al. (2001)
PNAS 98, 7946-7951
 |  Abstract »  |  Full Text »  |  PDF »

Genomic Scan for Exercise Blood Pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study.

T. Rankinen, P. An, T. Rice, G. Sun, Y. C. Chagnon, J. Gagnon, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, et al. (2001)
Hypertension 38, 30-37
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Peaks and Valleys.

F. C. Luft and A. Busjahn (2001)
Hypertension 38, 38-40
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Salt -- The DASH-Sodium trial.

F. J He and G. A MacGregor (2001)
Journal of Renin-Angiotensin-Aldosterone System 2, 93-95
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Mutations in the Na-Cl Cotransporter Reduce Blood Pressure in Humans.

D. N. Cruz, D. B. Simon, C. Nelson-Williams, A. Farhi, K. Finberg, L. Burleson, J. R. Gill, and R. P. Lifton (2001)
Hypertension 37, 1458-1464
 |  Abstract »  |  Full Text »  |  PDF »

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.

V. R. Holla, F. Adas, J. D. Imig, X. Zhao, E. Price Jr., N. Olsen, W. J. Kovacs, M. A. Magnuson, D. S. Keeney, M. D. Breyer, et al. (2001)
PNAS 98, 5211-5216
 |  Abstract »  |  Full Text »  |  PDF »

The renal tubular Na-Cl co-transporter (NCCT): a potential genetic link between blood pressure and bone density?.

D. N. Cruz (2001)
Nephrol. Dial. Transplant. 16, 691-694
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Association Analysis of {beta}2-Adrenergic Receptor Polymorphisms With Hypertension in Japanese.

N. Kato, T. Sugiyama, H. Morita, H. Kurihara, T. Sato, Y. Yamori, and Y. Yazaki (2001)
Hypertension 37, 286-292
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Gating Induces a Conformational Change in the Outer Vestibule of Enac.

P. M. Snyder, D. B. Bucher, and D. R. Olson (2000)
J. Gen. Physiol. 116, 781-790
 |  Abstract »  |  Full Text »  |  PDF »

Renal Protein Phosphatase 2A Activity and Spontaneous Hypertension in Rats.

P. Yu, L. D. Asico, G. M. Eisner, U. Hopfer, R. A. Felder, and P. A. Jose (2000)
Hypertension 36, 1053-1058
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Roles of the Renal Apical Sodium Transport Systems in Blood Pressure Control.

P. MENETON (2000)
J. Am. Soc. Nephrol. 11, S135-S139
 |  Abstract »  |  Full Text »  |  PDF »

Genome-Wide Linkage Analysis of Systolic and Diastolic Blood Pressure : The Quebec Family Study.

T. Rice, T. Rankinen, M. A. Province, Y. C. Chagnon, L. Perusse, I. B. Borecki, C. Bouchard, and D. C. Rao (2000)
Circulation 102, 1956-1963
 |  Abstract »  |  Full Text »  |  PDF »

Allergy-Associated Polymorphisms of the Fc{epsilon}RI{beta} Subunit Do Not Impact Its Two Amplification Functions.

E. Donnadieu, W. O. Cookson, M.-H. Jouvin, and J.-P. Kinet (2000)
J. Immunol. 165, 3917-3922
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in the Chloride Channel Gene CLCNKB as a Cause of Classic Bartter Syndrome.

M. KONRAD, M. VOLLMER, H. H. LEMMINK, L. P. W. J. VAN DEN HEUVEL, N. JECK, R. VARGAS-POUSSOU, A. LAKINGS, R. RUF, G. DESCHÊNES, C. ANTIGNAC, et al. (2000)
J. Am. Soc. Nephrol. 11, 1449-1459
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Activating Mineralocorticoid Receptor Mutation in Hypertension Exacerbated by Pregnancy.

D. S. Geller, A. Farhi, N. Pinkerton, M. Fradley, M. Moritz, A. Spitzer, G. Meinke, F. T. F. Tsai, P. B. Sigler, and R. P. Lifton (2000)
Science 289, 119-123
 |  Abstract »  |  Full Text »

QTL Influencing Blood Pressure Maps to the Region of PPH1 on Chromosome 2q31-34 in Old Order Amish.

W.-C. Hsueh, B. D. Mitchell, J. L. Schneider, M. J. Wagner, C. J. Bell, E. Nanthakumar, and A. R. Shuldiner (2000)
Circulation 101, 2810-2816
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Essential Hypertension : Part I: Definition and Etiology.

O. A. Carretero and S. Oparil (2000)
Circulation 101, 329-335
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Recent advances: Nephrology.

C R V Tomson (2000)
BMJ 320, 98-101
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Genetic Analysis of Inherited Hypertension in the Rat.

J. P. Rapp (2000)
Physiol Rev 80, 135-172
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A Mouse Model for Liddle's Syndrome.

S. PRADERVAND, Q. WANG, M. BURNIER, F. BEERMANN, J. D. HORISBERGER, E. HUMMLER, and B. C. ROSSIER (1999)
J. Am. Soc. Nephrol. 10, 2527-2533
 |  Abstract »  |  Full Text »

Hypertensive nephrosclerosis: pathogenesis and prevalence : Essential hypertension is an important cause of end-stage renal disease.

R. G. Luke (1999)
Nephrol. Dial. Transplant. 14, 2271-2278
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A Pore Segment in DEG/ENaC Na+ Channels.

P. M. Snyder, D. R. Olson, and D. B. Bucher (1999)
J. Biol. Chem. 274, 28484-28490
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Genome Scan for Blood Pressure Loci in Mice.

F. A. Wright, D. T. O'Connor, E. Roberts, G. Kutey, C. C. Berry, L. U. Yoneda, D. Timberlake, and G. Schlager (1999)
Hypertension 34, 625-630
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Congenic Substitution Mapping Excludes Sa as a Candidate Gene Locus for a Blood Pressure Quantitative Trait Locus on Rat Chromosome 1.

N. Hubner, Y.-A. Lee, K. Lindpaintner, D. Ganten, and R. Kreutz (1999)
Hypertension 34, 643-648
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The Role of {alpha}-Adducin Polymorphism in Blood Pressure and Sodium Handling Regulation May Not Be Excluded by a Negative Association Study.

N. Glorioso, P. Manunta, F. Filigheddu, C. Troffa, P. Stella, C. Barlassina, C. Lombardi, A. Soro, F. Dettori, P. P. Parpaglia, et al. (1999)
Hypertension 34, 649-654
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Number of Subunits Comprising the Epithelial Sodium Channel.

S. Eskandari, P. M. Snyder, M. Kreman, G. A. Zampighi, M. J. Welsh, and E. M. Wright (1999)
J. Biol. Chem. 274, 27281-27286
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Low-Renin and Nonmodulating Essential Hypertension.

D. G. Warnock (1999)
Hypertension 34, 395-397
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Angiotensinogen Gene Polymorphism Near Transcription Start Site and Blood Pressure : Role of a T-to-C Transition at Intron I.

T. Ishigami, K. Tamura, T. Fujita, I. Kobayashi, K. Hibi, M. Kihara, Y. Toya, H. Ochiai, and S. Umemura (1999)
Hypertension 34, 430-434
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Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17.

J. Baima, M. Nicolaou, F. Schwartz, A. L. DeStefano, A. Manolis, I. Gavras, C. Laffer, F. Elijovich, L. Farrer, C. T. Baldwin, et al. (1999)
Hypertension 34, 4-7
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A Novel Mechanism of Ion Homeostasis and Salt Tolerance in Yeast: the Hal4 and Hal5 Protein Kinases Modulate the Trk1-Trk2 Potassium Transporter.

J. M. Mulet, M. P. Leube, S. J. Kron, G. Rios, G. R. Fink, and R. Serrano (1999)
Mol. Cell. Biol. 19, 3328-3337
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To salt, or not to salt?.

T. A. Kotchen (1999)
Am J Physiol Heart Circ Physiol 276, H1807-H1808
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Glucocorticoid Induction of Epithelial Sodium Channel Expression in Lung and Renal Epithelia Occurs via trans-Activation of a Hormone Response Element in the 5'-Flanking Region of the Human Epithelial Sodium Channel alpha  Subunit Gene.

R. Sayegh, S. D. Auerbach, X. Li, R. W. Loftus, R. F. Husted, J. B. Stokes, and C. P. Thomas (1999)
J. Biol. Chem. 274, 12431-12437
 |  Abstract »  |  Full Text »  |  PDF »

Linkage analysis of glucocorticoid and beta 2-adrenergic receptor genes with blood pressure and body mass index.

S. Takami, Z. Y. H. Wong, M. Stebbing, and S. B. Harrap (1999)
Am J Physiol Heart Circ Physiol 276, H1379-H1384
 |  Abstract »  |  Full Text »  |  PDF »

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