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Science 26 April 1996:
Vol. 272. no. 5261, pp. 542 - 545
DOI: 10.1126/science.272.5261.542
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Reports

Selective Activation of NF-kappa B by Nerve Growth Factor Through the Neurotrophin Receptor p75

Bruce D. Carter, *dagger Christian Kaltschmidt, * Barbara Kaltschmidt, Nina Offenhäuser, ddagger Renate Böhm-Matthaei, Patrick A. Baeuerle, § Yves-Alain Barde

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) selectively bind to distinct members of the Trk family of tyrosine kinase receptors, but all three bind with similar affinities to the neurotrophin receptor p75 (p75NTR). The biological significance of neurotrophin binding to p75NTR in cells that also express Trk receptors has been difficult to ascertain. In the absence of TrkA, NGF binding to p75NTR activated the transcription factor nuclear factor kappa B (NF-kappa B) in rat Schwann cells. This activation was not observed in Schwann cells isolated from mice that lacked p75NTR. The effect was selective for NGF; NF-kappa B was not activated by BDNF or NT-3.

B. D. Carter and Y.-A. Barde, Department of Neurobiochemistry, Max-Planck Institute for Psychiatry, Martinsried, Germany.
C. Kaltschmidt, B. Kaltschmidt, P. A. Baeuerle, Institute for Biochemistry, University of Freiburg, Freiburg, Germany.
N. Offenhäuser and R. Böhm-Mattaei, Department of Neurochemistry, Max-Planck Institute for Psychiatry, Martinsried, Germany.
* These authors contributed equally to this work.
dagger Present address: Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021, USA.
ddagger Present address: European Institute of Oncology, 20141, Milan, Italy.
§ Present address: Tularik Incorporated, South San Francisco, CA 94080, USA.


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   Abstract »    Full Text »    PDF »
A Role for Nuclear Factor kappa B in the Antiapoptotic Function of Insulin.
F. Bertrand, A. Atfi, A. Cadoret, G. L'Allemain, H. Robin, O. Lascols, J. Capeau, and G. Cherqui (1998)
J. Biol. Chem. 273, 2931-2938
   Abstract »    Full Text »    PDF »
Nerve growth factor and ceramides modulate cell death in the early developing inner ear.
L. Frago, Y Leon, E. de la Rosa, A Gomez-Munoz, and I Varela-Nieto (1998)
J. Cell Sci. 111, 549-556
   Abstract »    PDF »
A Second Determinant of Binding to the p75 Neurotrophin Receptor Revealed by Alanine-scanning Mutagenesis of a Conserved Loop in Nerve Growth Factor.
M. Ryden and C. F. Ibanez (1997)
J. Biol. Chem. 272, 33085-33091
   Abstract »    Full Text »    PDF »
The Role of the Nerve Growth Factor Carboxyl Terminus in Receptor Binding and Conformational Stability.
A. Kruttgen, J. V. Heymach Jr., P. J. Kahle, and E. M. Shooter (1997)
J. Biol. Chem. 272, 29222-29228
   Abstract »    Full Text »    PDF »
Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial.
S E Edmonds, P G Winyard, R Guo, B Kidd, P Merry, A Langrish-Smith, C Hansen, S Ramm, and D R Blake (1997)
Ann Rheum Dis 56, 649-655
   Abstract »    Full Text »
Activation of the HIV-1 Long Terminal Repeat by Nerve Growth Factor.
J. A. Recio and A. Aranda (1997)
J. Biol. Chem. 272, 26807-26810
   Abstract »    Full Text »    PDF »
Absence of p75NTR Causes Increased Basal Forebrain Cholinergic Neuron Size, Choline Acetyltransferase Activity, and Target Innervation.
T. T. Yeo, J. Chua-Couzens, L. L. Butcher, D. E. Bredesen, J. D. Cooper, J. S. Valletta, W. C. Mobley, and F. M. Longo (1997)
J. Neurosci. 17, 7594-7605
   Abstract »    Full Text »    PDF »
Interactions between Brain-derived Neurotrophic Factor and the TRKB Receptor. IDENTIFICATION OF TWO LIGAND BINDING DOMAINS IN SOLUBLE TRKB BY AFFINITY SEPARATION AND CHEMICAL CROSS-LINKING.
M. Haniu, S. Montestruque, E. J. Bures, J. Talvenheimo, R. Toso, S. Lewis-Sandy, A. A. Welcher, and M. F. Rohde (1997)
J. Biol. Chem. 272, 25296-25303
   Abstract »    Full Text »    PDF »
Brain-derived Neurotrophic Factor Binding to the p75 Neurotrophin Receptor Reduces TrkA Signaling While Increasing Serine Phosphorylation in the TrkA Intracellular Domain.
I. J. MacPhee and P. A. Barker (1997)
J. Biol. Chem. 272, 23547-23551
   Abstract »    Full Text »    PDF »
A Novel, Nerve Growth Factor-activated Pathway Involving Nitric Oxide, p53, and p21WAF1 Regulates Neuronal Differentiation of PC12 Cells.
W. Poluha, C. M. Schonhoff, K. S. Harrington, M. B. Lachyankar, N. E. Crosbie, D. A. Bulseco, and A. H. Ross (1997)
J. Biol. Chem. 272, 24002-24007
   Abstract »    Full Text »    PDF »
Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation.
L. C. Edsall, G. G. Pirianov, and S. Spiegel (1997)
J. Neurosci. 17, 6952-6960
   Abstract »    Full Text »    PDF »
Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis.
M. Majdan, C. Lachance, A. Gloster, R. Aloyz, C. Zeindler, S. Bamji, A. Bhakar, D. Belliveau, J. Fawcett, F. D. Miller, et al. (1997)
J. Neurosci. 17, 6988-6998
   Abstract »    Full Text »    PDF »
A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.
M. L. Grimes, E. Beattie, and W. C. Mobley (1997)
PNAS 94, 9909-9914
   Abstract »    Full Text »    PDF »
Optimal Nerve Growth Factor Trophic Signals Mediated by Synergy of TrkA and p75 Receptor-Specific Ligands.
S. Maliartchouk and H. U. Saragovi (1997)
J. Neurosci. 17, 6031-6037
   Abstract »    Full Text »    PDF »
The Neurotrophin Receptor p75 Binds Neurotrophin-3 on Sympathetic Neurons with High Affinity and Specificity.
G. Dechant, P. Tsoulfas, L. F. Parada, and Y.-A. Barde (1997)
J. Neurosci. 17, 5281-5287
   Abstract »    Full Text »    PDF »
Differential Modulation of Neuron Survival during Development by Nerve Growth Factor Binding to the p75 Neurotrophin Receptor.
M. Ryden, B. Hempstead, and C. F. Ibanez (1997)
J. Biol. Chem. 272, 16322-16328
   Abstract »    Full Text »    PDF »
The Low-Affinity Neurotrophin Receptor p75 Regulates the Function But Not the Selective Survival of Specific Subpopulations of Sensory Neurons.
C. L. Stucky and M. Koltzenburg (1997)
J. Neurosci. 17, 4398-4405
   Abstract »    Full Text »    PDF »
Association of p75NTR with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to Caveolae.
T. R. Bilderback, R. J. Grigsby, and R. T. Dobrowsky (1997)
J. Biol. Chem. 272, 10922-10927
   Abstract »    Full Text »    PDF »


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