Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 April 1996:
Vol. 272. no. 5259, pp. 227 - 234
DOI: 10.1126/science.272.5259.227
Prev | Table of Contents | Next

Articles

Protein Sorting by Transport Vesicles

James E. Rothman * and Felix T. Wieland

Eukaryotic life depends on the spatial and temporal organization of cellular membrane systems. Recent advances in understanding the machinery of vesicle transport have established general principles that underlie a broad variety of physiological processes, including cell surface growth, the biogenesis of distinct intracellular organelles, endocytosis, and the controlled release of hormones and neurotransmitters.

J. E. Rothman is in the Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
F. T. Wieland is at the Institut für Biochemie I, University of Heidelberg, Im Neuenheimer Feld 28, Heidelberg, Germany.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Rice {alpha}-Amylase Glycoprotein Is Targeted from the Golgi Apparatus through the Secretory Pathway to the Plastids.
A. Kitajima, S. Asatsuma, H. Okada, Y. Hamada, K. Kaneko, Y. Nanjo, Y. Kawagoe, K. Toyooka, K. Matsuoka, M. Takeuchi, et al. (2009)
PLANT CELL 21, 2844-2858
   Abstract »    Full Text »    PDF »
Functional analysis of GS28, an intra-Golgi SNARE, in Caenorhabditis elegans.
M. Maekawa, T. Inoue, H. Kobuna, T. Nishimura, K. Gengyo-Ando, S. Mitani, and H. Arai (2009)
Genes Cells 14, 1003-1013
   Abstract »    Full Text »    PDF »
Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.
E. Puxeddu, M. Uhart, C.-C. Li, F. Ahmad, G. Pacheco-Rodriguez, V. C. Manganiello, J. Moss, and M. Vaughan (2009)
PNAS 106, 6158-6163
   Abstract »    Full Text »    PDF »
Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution.
J. B. Dacks, P. P. Poon, and M. C. Field (2008)
PNAS 105, 588-593
   Abstract »    Full Text »    PDF »
Identification of Human T Cell Leukemia Virus Type 1 Tax Amino Acid Signals and Cellular Factors Involved in Secretion of the Viral Oncoprotein.
P. Jain, K. Mostoller, K. E. Flaig, J. Ahuja, V. Lepoutre, T. Alefantis, Z. K. Khan, and B. Wigdahl (2007)
J. Biol. Chem. 282, 34581-34593
   Abstract »    Full Text »    PDF »
ARF1-mediated actin polymerization produces movement of artificial vesicles.
J. Heuvingh, M. Franco, P. Chavrier, and C. Sykes (2007)
PNAS 104, 16928-16933
   Abstract »    Full Text »    PDF »
Confocal Microscopy-based Linescan Methodologies for Intra-Golgi Localization of Proteins.
S. Yilmaz Dejgaard, A. Murshid, K. M. Dee, and J. F. Presley (2007)
J. Histochem. Cytochem. 55, 709-719
   Abstract »    Full Text »    PDF »
Differential localization of coatomer complex isoforms within the Golgi apparatus.
J. Moelleken, J. Malsam, M. J. Betts, A. Movafeghi, I. Reckmann, I. Meissner, A. Hellwig, R. B. Russell, T. Sollner, B. Brugger, et al. (2007)
PNAS 104, 4425-4430
   Abstract »    Full Text »    PDF »
Cell-surface heparan sulfate proteoglycans are essential components of the unconventional export machinery of FGF-2.
C. Zehe, A. Engling, S. Wegehingel, T. Schafer, and W. Nickel (2006)
PNAS 103, 15479-15484
   Abstract »    Full Text »    PDF »
Exomer: a coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast.
C.-W. Wang, S. Hamamoto, L. Orci, and R. Schekman (2006)
J. Cell Biol. 174, 973-983
   Abstract »    Full Text »    PDF »
Identification and characterization of p63 (CKAP4/ERGIC-63/CLIMP-63), a surfactant protein A binding protein, on type II pneumocytes.
N. Gupta, Y. Manevich, A. S. Kazi, J.-Q. Tao, A. B. Fisher, and S. R. Bates (2006)
Am J Physiol Lung Cell Mol Physiol 291, L436-L446
   Abstract »    Full Text »    PDF »
Dense-Core Secretory Granule Biogenesis.
T. Kim, M. C. Gondre-Lewis, I. Arnaoutova, and Y. P. Loh (2006)
Physiology 21, 124-133
   Abstract »    Full Text »    PDF »
Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake.
X. Shen, K.-F. Xu, Q. Fan, G. Pacheco-Rodriguez, J. Moss, and M. Vaughan (2006)
PNAS 103, 2635-2640
   Abstract »    Full Text »    PDF »
Mutants in trs120 disrupt traffic from the early endosome to the late Golgi.
H. Cai, Y. Zhang, M. Pypaert, L. Walker, and S. Ferro-Novick (2005)
J. Cell Biol. 171, 823-833
   Abstract »    Full Text »    PDF »
Binding and Functions of ADP-ribosylation Factor on Mammalian and Yeast Peroxisomes.
D. Lay, B. L. Grosshans, H. Heid, K. Gorgas, and W. W. Just (2005)
J. Biol. Chem. 280, 34489-34499
   Abstract »    Full Text »    PDF »
Constitutive secretion of serum albumin requires reversible protein tyrosine phosphorylation events in trans-Golgi.
R. J. Webb, J. D. Judah, L.-C. Lo, and G. M. H. Thomas (2005)
Am J Physiol Cell Physiol 289, C748-C756
   Abstract »    Full Text »    PDF »
A Novel Inhibitor of N-Ethylmaleimide-Sensitive Factor Decreases Leukocyte Trafficking and Peritonitis.
C. N. Morrell, K. Matsushita, and C. J. Lowenstein (2005)
J. Pharmacol. Exp. Ther. 314, 155-161
   Abstract »    Full Text »    PDF »
Parotid Secretory Granules: Crossroads of Secretory Pathways and Protein Storage.
S.-U. Gorr, S.G. Venkatesh, and D.S. Darling (2005)
Journal of Dental Research 84, 500-509
   Abstract »    Full Text »    PDF »
Beyond the Signal Sequence: Protein Routing in Health and Disease.
C. Castro-Fernandez, G. Maya-Nunez, and P. M. Conn (2005)
Endocr. Rev. 26, 479-503
   Abstract »    Full Text »    PDF »
SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane.
C. Juschke, A. Wachter, B. Schwappach, and M. Seedorf (2005)
J. Cell Biol. 169, 613-622
   Abstract »    Full Text »    PDF »
ATP Binding Regulates Oligomerization and Endosome Association of RME-1 Family Proteins.
D.-w. Lee, X. Zhao, S. Scarselletta, P. J. Schweinsberg, E. Eisenberg, B. D. Grant, and L. E. Greene (2005)
J. Biol. Chem. 280, 17213-17220
   Abstract »    Full Text »    PDF »
Effects of Foot-and-Mouth Disease Virus Nonstructural Proteins on the Structure and Function of the Early Secretory Pathway: 2BC but Not 3A Blocks Endoplasmic Reticulum-to-Golgi Transport.
K. Moffat, G. Howell, C. Knox, G. J. Belsham, P. Monaghan, M. D. Ryan, and T. Wileman (2005)
J. Virol. 79, 4382-4395
   Abstract »    Full Text »    PDF »
The Rate-limiting Enzyme in Phosphatidylcholine Synthesis Regulates Proliferation of the Nucleoplasmic Reticulum.
T. A. Lagace and N. D. Ridgway (2005)
Mol. Biol. Cell 16, 1120-1130
   Abstract »    Full Text »    PDF »
Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant.
C. Stegmayer, A. Kehlenbach, S. Tournaviti, S. Wegehingel, C. Zehe, P. Denny, D. F. Smith, B. Schwappach, and W. Nickel (2005)
J. Cell Sci. 118, 517-527
   Abstract »    Full Text »    PDF »
Generation of nonidentical compartments in vesicular transport systems.
R. Heinrich and T. A. Rapoport (2005)
J. Cell Biol. 168, 271-280
   Abstract »    Full Text »    PDF »
The Transmembrane Domains of the prM and E Proteins of Yellow Fever Virus Are Endoplasmic Reticulum Localization Signals.
A. Op De Beeck, Y. Rouille, M. Caron, S. Duvet, and J. Dubuisson (2004)
J. Virol. 78, 12591-12602
   Abstract »    Full Text »    PDF »
Clathrin-Dependent Targeting of Receptors to the Flagellar Pocket of Procyclic-Form Trypanosoma brucei.
C.-H. Hung, X. Qiao, P.-T. Lee, and M. G.-S. Lee (2004)
Eukaryot. Cell 3, 1004-1014
   Abstract »    Full Text »    PDF »
Tip20p Prohibits Back-Fusion of COPII Vesicles with the Endoplasmic Reticulum.
F. Kamena and A. Spang (2004)
Science 304, 286-289
   Abstract »    Full Text »    PDF »
The Vesicular Acetylcholine Transporter Interacts with Clathrin-associated Adaptor Complexes AP-1 and AP-2.
M.-H. Kim and L. B. Hersh (2004)
J. Biol. Chem. 279, 12580-12587
   Abstract »    Full Text »    PDF »
Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
P. I. Padilla, G. Pacheco-Rodriguez, J. Moss, and M. Vaughan (2004)
PNAS 101, 2752-2757
   Abstract »    Full Text »    PDF »
The {alpha}- and {beta}'-COP WD40 Domains Mediate Cargo-selective Interactions with Distinct Di-lysine Motifs.
A. Eugster, G. Frigerio, M. Dale, and R. Duden (2004)
Mol. Biol. Cell 15, 1011-1023
   Abstract »    Full Text »    PDF »
Unconventional Secretion of Fibroblast Growth Factor 2 Is Mediated by Direct Translocation across the Plasma Membrane of Mammalian Cells.
T. Schafer, H. Zentgraf, C. Zehe, B. Brugger, J. Bernhagen, and W. Nickel (2004)
J. Biol. Chem. 279, 6244-6251
   Abstract »    Full Text »    PDF »
From The Cover: The gene for soluble N-ethylmaleimide sensitive factor attachment protein {alpha} is mutated in hydrocephaly with hop gait (hyh) mice.
H.-K. Hong, A. Chakravarti, and J. S. Takahashi (2004)
PNAS 101, 1748-1753
   Abstract »    Full Text »    PDF »
Novel Isotypic {gamma}/{zeta} Subunits Reveal Three Coatomer Complexes in Mammals.
D. Wegmann, P. Hess, C. Baier, F. T. Wieland, and C. Reinhard (2004)
Mol. Cell. Biol. 24, 1070-1080
   Abstract »    Full Text »    PDF »
C-Terminal Truncation of {alpha}-COP Affects Functioning of Secretory Organelles and Calcium Homeostasis in Hansenula polymorpha.
M. B. Chechenova, N. V. Romanova, A. V. Deev, A. N. Packeiser, V. N. Smirnov, M. O. Agaphonov, and M. D. Ter-Avanesyan (2004)
Eukaryot. Cell 3, 52-60
   Abstract »    Full Text »    PDF »
Involvement of the AP-1 Adaptor Complex in Early Steps of Phagocytosis and Macropinocytosis.
Y. Lefkir, M. Malbouyres, D. Gotthardt, A. Ozinsky, S. Cornillon, F. Bruckert, A. A. Aderem, T. Soldati, P. Cosson, and F. Letourneur (2004)
Mol. Biol. Cell 15, 861-869
   Abstract »    Full Text »    PDF »
Quality control of MHC class I maturation.
K. M. PAULSSON and P. WANG (2004)
FASEB J 18, 31-38
   Abstract »    Full Text »    PDF »
Apolipoprotein B100 Exit from the Endoplasmic Reticulum (ER) Is COPII-dependent, and Its Lipidation to Very Low Density Lipoprotein Occurs Post-ER.
V. Gusarova, J. L. Brodsky, and E. A. Fisher (2003)
J. Biol. Chem. 278, 48051-48058
   Abstract »    Full Text »    PDF »
Artificially controlled aggregation of proteins and targeting in hematopoietic cells.
H. Rosen, Y. Gao, E. Johnsson, and I. Olsson (2003)
J. Leukoc. Biol. 74, 800-809
   Abstract »    Full Text »    PDF »
Mechanism of Constitutive Export from the Golgi: Bulk Flow via the Formation, Protrusion, and En Bloc Cleavage of large trans-Golgi Network Tubular Domains.
E. V. Polishchuk, A. Di Pentima, A. Luini, and R. S. Polishchuk (2003)
Mol. Biol. Cell 14, 4470-4485
   Abstract »    Full Text »    PDF »
Rab GTPases Are Recruited to Chlamydial Inclusions in Both a Species-Dependent and Species-Independent Manner.
K. A. Rzomp, L. D. Scholtes, B. J. Briggs, G. R. Whittaker, and M. A. Scidmore (2003)
Infect. Immun. 71, 5855-5870
   Abstract »    Full Text »    PDF »
The Caenorhabditis elegans spe-39 Gene Is Required for Intracellular Membrane Reorganization During Spermatogenesis.
G.-d. Zhu and S. W. L'Hernault (2003)
Genetics 165, 145-157
   Abstract »    Full Text »    PDF »
Evidence that the transport of ricin to the cytoplasm is independent of both Rab6A and COPI.
A. Chen, R. J. AbuJarour, and R. K. Draper (2003)
J. Cell Sci. 116, 3503-3510
   Abstract »    Full Text »    PDF »
Endoplasmic Reticulum Export of Glycosyltransferases Depends on Interaction of a Cytoplasmic Dibasic Motif with Sar1.
C. G. Giraudo and H. J.F. Maccioni (2003)
Mol. Biol. Cell 14, 3753-3766
   Abstract »    Full Text »    PDF »
Functional reconstitution of COPI coat assembly and disassembly using chemically defined components.
C. Reinhard, M. Schweikert, F. T. Wieland, and W. Nickel (2003)
PNAS 100, 8253-8257
   Abstract »    Full Text »    PDF »
The Cytoplasmic Domain of Vamp4 and Vamp5 Is Responsible for Their Correct Subcellular Targeting: THE N-TERMINAL EXTENSION OF VAMP4 CONTAINS A DOMINANT AUTONOMOUS TARGETING SIGNAL FOR THE TRANS-GOLGI NETWORK.
Q. Zeng, T. T. H. Tran, H.-X. Tan, and W. Hong (2003)
J. Biol. Chem. 278, 23046-23054
   Abstract »    Full Text »    PDF »
ADP-Ribosylation Factor/COPI-dependent Events at the Endoplasmic Reticulum-Golgi Interface Are Regulated by the Guanine Nucleotide Exchange Factor GBF1.
R. Garcia-Mata, T. Szul, C. Alvarez, and E. Sztul (2003)
Mol. Biol. Cell 14, 2250-2261
   Abstract »    Full Text »    PDF »
Tomographic Evidence for Continuous Turnover of Golgi Cisternae in Pichia pastoris.
S. Mogelsvang, N. Gomez-Ospina, J. Soderholm, B. S. Glick, and L. A. Staehelin (2003)
Mol. Biol. Cell 14, 2277-2291
   Abstract »    Full Text »    PDF »
Surface Expression of Inward Rectifier Potassium Channels Is Controlled by Selective Golgi Export.
C. Stockklausner and N. Klocker (2003)
J. Biol. Chem. 278, 17000-17005
   Abstract »    Full Text »    PDF »
logjam Encodes a Predicted EMP24/GP25 Protein That Is Required for Drosophila Oviposition Behavior.
G. E. Carney and B. J. Taylor (2003)
Genetics 164, 173-186
   Abstract »    Full Text »    PDF »
The AP-1 Clathrin-adaptor Is Required for Lysosomal Enzymes Sorting and Biogenesis of the Contractile Vacuole Complex in Dictyostelium Cells.
Y. Lefkir, B. de Chassey, A. Dubois, A. Bogdanovic, R. J. Brady, O. Destaing, F. Bruckert, T. J. O'Halloran, P. Cosson, and F. Letourneur (2003)
Mol. Biol. Cell 14, 1835-1851
   Abstract »    Full Text »    PDF »
Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae.
L. Orci, M. Ravazzola, G. J. Mack, C. Barlowe, and S. Otte (2003)
PNAS 100, 4586-4591
   Abstract »    Full Text »    PDF »
Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506.
P. I. Padilla, M.-j. Chang, G. Pacheco-Rodriguez, R. Adamik, J. Moss, and M. Vaughan (2003)
PNAS 100, 2322-2327
   Abstract »    Full Text »    PDF »
Determinant for Endoplasmic Reticulum Retention in the Luminal Domain of the Human Cytomegalovirus US3 Glycoprotein.
S. Lee, B. Park, and K. Ahn (2003)
J. Virol. 77, 2147-2156
   Abstract »    Full Text »    PDF »
In Vitro Transport on Cis and Trans Sides of the Golgi Involves Two Distinct Types of Coatomer and ADP-ribosylation Factor-independent Transport Intermediates.
A. K. Pullikuth and P. J. Weidman (2002)
J. Biol. Chem. 277, 50355-50364
   Abstract »    Full Text »    PDF »
Identification of an Axotomy-Induced Glycosylated Protein, AIGP1, Possibly Involved in Cell Death Triggered by Endoplasmic Reticulum-Golgi Stress.
S. Aoki, Q. Su, H. Li, K. Nishikawa, K. Ayukawa, Y. Hara, K. Namikawa, S. Kiryu-Seo, H. Kiyama, and K. Wada (2002)
J. Neurosci. 22, 10751-10760
   Abstract »    Full Text »    PDF »
Ultrastructural characterization of endoplasmic reticulum -- Golgi transport containers (EGTC).
H. Horstmann, C. P. Ng, B. L. Tang, and W. Hong (2002)
J. Cell Sci. 115, 4263-4273
   Abstract »    Full Text »    PDF »
NSF regulates membrane traffic along multiple pathways in Paramecium.
R. Kissmehl, M. Froissard, H. Plattner, M. Momayezi, and J. Cohen (2002)
J. Cell Sci. 115, 3935-3946
   Abstract »    Full Text »    PDF »
Modifications of Golgi Complex in Chondrocytes from Osteoarthrotic (OA) Rat Cartilage.
J. B. Kouri, L. Rojas, E. Perez, and K. A. Abbud-Lozoya (2002)
J. Histochem. Cytochem. 50, 1333-1340
   Abstract »    Full Text »    PDF »
GS15 Forms a SNARE Complex with Syntaxin 5, GS28, and Ykt6 and Is Implicated in Traffic in the Early Cisternae of the Golgi Apparatus.
Y. Xu, S. Martin, D. E. James, and W. Hong (2002)
Mol. Biol. Cell 13, 3493-3507
   Abstract »    Full Text »    PDF »
Disruption of Golgi Morphology and Trafficking in Cells Expressing Mutant Prenylated Rab Acceptor-1.
P.-Y. Gougeon, D. C. Prosser, L. F. Da-Silva, and J. K. Ngsee (2002)
J. Biol. Chem. 277, 36408-36414
   Abstract »    Full Text »    PDF »
Sec16p potentiates the action of COPII proteins to bud transport vesicles.
F. Supek, D. T. Madden, S. Hamamoto, L. Orci, and R. Schekman (2002)
J. Cell Biol. 158, 1029-1038
   Abstract »    Full Text »    PDF »
Biosynthetic FGF-2 is targeted to non-lipid raft microdomains following translocation to the extracellular surface of CHO cells.
A. Engling, R. Backhaus, C. Stegmayer, C. Zehe, C. Seelenmeyer, A. Kehlenbach, B. Schwappach, S. Wegehingel, and W. Nickel (2002)
J. Cell Sci. 115, 3619-3631
   Abstract »    Full Text »    PDF »
Functional involvement of VAMP/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells.
S. Gouraud, A. Laera, G. Calamita, M. Carmosino, G. Procino, O. Rossetto, R. Mannucci, W. Rosenthal, M. Svelto, and G. Valenti (2002)
J. Cell Sci. 115, 3667-3674
   Abstract »    Full Text »    PDF »
Vesicular transport: the core machinery of COPI recruitment and budding.
W. Nickel, B. Brugger, and F. T. Wieland (2002)
J. Cell Sci. 115, 3235-3240
   Abstract »    Full Text »    PDF »
Role of KIFC3 motor protein in Golgi positioning and integration.
Y. Xu, S. Takeda, T. Nakata, Y. Noda, Y. Tanaka, and N. Hirokawa (2002)
J. Cell Biol. 158, 293-303
   Abstract »    Full Text »    PDF »
Salt Induction of Fatty Acid Elongase and Membrane Lipid Modifications in the Extreme Halotolerant Alga Dunaliella salina.
M. Azachi, A. Sadka, M. Fisher, P. Goldshlag, I. Gokhman, and A. Zamir (2002)
Plant Physiology 129, 1320-1329
   Abstract »    Full Text »    PDF »
Membrane Protein Transport between the Endoplasmic Reticulum and the Golgi in Tobacco Leaves Is Energy Dependent but Cytoskeleton Independent: Evidence from Selective Photobleaching.
F. Brandizzi, E. L. Snapp, A. G. Roberts, J. Lippincott-Schwartz, and C. Hawes (2002)
PLANT CELL 14, 1293-1309
   Abstract »    Full Text »    PDF »
ER-Golgi Traffic Is a Prerequisite for Efficient ER Degradation.
C. Taxis, F. Vogel, and D. H. Wolf (2002)
Mol. Biol. Cell 13, 1806-1818
   Abstract »    Full Text »    PDF »
Association of Tapasin and COPI Provides a Mechanism for the Retrograde Transport of Major Histocompatibility Complex (MHC) Class I Molecules from the Golgi Complex to the Endoplasmic Reticulum.
K. M. Paulsson, M. J. Kleijmeer, J. Griffith, M. Jevon, S. Chen, P. O. Anderson, H.-O. Sjogren, S. Li, and P. Wang (2002)
J. Biol. Chem. 277, 18266-18271
   Abstract »    Full Text »    PDF »
Imaging of procollagen transport reveals COPI-dependent cargo sorting during ER-to-Golgi transport in mammalian cells.
D. J. Stephens and R. Pepperkok (2002)
J. Cell Sci. 115, 1149-1160
   Abstract »    Full Text »    PDF »
Regulation of Golgi structure and function by ARF-like protein 1 (Arl1).
L. Lu, H. Horstmann, C. Ng, and W. Hong (2002)
J. Cell Sci. 114, 4543-4555
   Abstract »    Full Text »    PDF »
Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus.
S.-i. Yoshimura, N. Nakamura, F. A. Barr, Y. Misumi, Y. Ikehara, H. Ohno, M. Sakaguchi, and K. Mihara (2002)
J. Cell Sci. 114, 4105-4115
   Abstract »    Full Text »    PDF »
Three dimensional configuration of the secretory pathway and segregation of secretion granules in the yeast Saccharomyces cerevisiae.
A. Rambourg, C. L. Jackson, and Y. Clermont (2002)
J. Cell Sci. 114, 2231-2239
   Abstract »    Full Text »    PDF »
Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform.
F. Mallard, B. L. Tang, T. Galli, D. Tenza, A. Saint-Pol, X. Yue, C. Antony, W. Hong, B. Goud, and L. Johannes (2002)
J. Cell Biol. 156, 653-664
   Abstract »    Full Text »    PDF »
Drosophila syntaxin 16 is a Q-SNARE implicated in Golgi dynamics.
H. Xu, G. L. Boulianne, and W. S. Trimble (2002)
J. Cell Sci. 115, 4447-4455
   Abstract »    Full Text »    PDF »
The Tlg SNARE complex is required for TGN homotypic fusion.
J. H. Brickner, J. M. Blanchette, G. Sipos, and R. S. Fuller (2001)
J. Cell Biol. 155, 969-978
   Abstract »    Full Text »    PDF »
The N-terminal Domain of the t-SNARE Vam3p Coordinates Priming and Docking in Yeast Vacuole Fusion.
R. Laage and C. Ungermann (2001)
Mol. Biol. Cell 12, 3375-3385
   Abstract »    Full Text »    PDF »
A Membrane Protein Enriched in Endoplasmic Reticulum Exit Sites Interacts with COPII.
B. L. Tang, Y. S. Ong, B. Huang, S. Wei, E. T. Wong, R. Qi, H. Horstmann, and W. Hong (2001)
J. Biol. Chem. 276, 40008-40017
   Abstract »    Full Text »    PDF »
Microsomal membrane-associated apoB is the direct precursor of secreted VLDL in primary cultures of rat hepatocytes.
A.-M. Hebbachi and G. F. Gibbons (2001)
J. Lipid Res. 42, 1609-1617
   Abstract »    Full Text »    PDF »
The Organizing Potential of Sphingolipids in Intracellular Membrane Transport.
J. C. M. Holthuis, T. Pomorski, R. J. Raggers, H. Sprong, and G. Van Meer (2001)
Physiol Rev 81, 1689-1723
   Abstract »    Full Text »    PDF »
Autophagy in Yeast: Mechanistic Insights and Physiological Function.
H. Abeliovich and D. J. Klionsky (2001)
Microbiol. Mol. Biol. Rev. 65, 463-479
   Abstract »    Full Text »    PDF »
Ca2+ influx and cAMP elevation overcame botulinum toxin A but not tetanus toxin inhibition of insulin exocytosis.
X. Huang, Y.-H. Kang, E. A. Pasyk, L. Sheu, M. B. Wheeler, W. S. Trimble, A. Salapatek, and H. Y. Gaisano (2001)
Am J Physiol Cell Physiol 281, C740-C750
   Abstract »    Full Text »    PDF »
A Low-Affinity Ca2+-Dependent Association of Calmodulin With the Rab3A Effector Domain Inversely Correlates With Insulin Exocytosis.
H. Kajio, S. Olszewski, P. J. Rosner, M. J. Donelan, K. F. Geoghegan, and C. J. Rhodes (2001)
Diabetes 50, 2029-2039
   Abstract »    Full Text »    PDF »
Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5.
R. T. Watson and J. E. Pessin (2001)
Am J Physiol Cell Physiol 281, C215-C223
   Abstract »    Full Text »    PDF »
Depletion of Acyl-Coenzyme A-Binding Protein Affects Sphingolipid Synthesis and Causes Vesicle Accumulation and Membrane Defects in Saccharomyces cerevisiae.
B. Gaigg, T. B. F. Neergaard, R. Schneiter, J. K. Hansen, N. J. Færgeman, N. A. Jensen, J. R. Andersen, J. Friis, R. Sandhoff, H. D. Schrøder, et al. (2001)
Mol. Biol. Cell 12, 1147-1160
   Abstract »    Full Text »
Ultrastructural Localization of Vesicle-associated Membrane Protein(s) to Specialized Membrane Structures in Human Pericytes, Vascular Smooth Muscle Cells, Endothelial Cells, Neutrophils, and Eosinophils.
D. Feng, R. Flaumenhaft, C. Bandeira–Melo, P. F. Weller, and A. M. Dvorak (2001)
J. Histochem. Cytochem. 49, 293-304
   Abstract »    Full Text »
ARF-GEP100, a guanine nucleotide-exchange protein for ADP-ribosylation factor 6.
A. Someya, M. Sata, K. Takeda, G. Pacheco-Rodriguez, V. J. Ferrans, J. Moss, and M. Vaughan (2001)
PNAS 98, 2413-2418
   Abstract »    Full Text »    PDF »
Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells{image}.
G. Raposo, D. Tenza, D. M. Murphy, J. F. Berson, and M. S. Marks (2001)
J. Cell Biol. 152, 809-824
   Abstract »    Full Text »    PDF »
Connection of the Mitochondrial Outer and Inner Membranes by Fzo1 Is Critical for Organellar Fusion.
S. Fritz, D. Rapaport, E. Klanner, W. Neupert, and B. Westermann (2001)
J. Cell Biol. 152, 683-692
   Abstract »    Full Text »    PDF »
A Di-Leucine Sequence and a Cluster of Acidic Amino Acids Are Required for Dynamic Retention in the Endosomal Recycling Compartment of Fibroblasts.
A. O. Johnson, M. A. Lampson, and T. E. McGraw (2001)
Mol. Biol. Cell 12, 367-381
   Abstract »    Full Text »
Roles of the cytoplasmic and transmembrane domains of syntaxins in intracellular localization and trafficking.
K. Kasai and K. Akagawa (2001)
J. Cell Sci. 114, 3115-3124
   Abstract »    Full Text »    PDF »
Peroxisomal membrane proteins are properly targeted to peroxisomes in the absence of COPI- and COPII-mediated vesicular transport.
T. Voorn-Brouwer, A. Kragt, H. F. Tabak, and B. Distel (2001)
J. Cell Sci. 114, 2199-2204
   Abstract »    Full Text »    PDF »
Illuminating the secretory pathway: when do we need vesicles?.
D. Stephens and R Pepperkok (2001)
J. Cell Sci. 114, 1053-1059
   Abstract »    PDF »
Divergence of Eukaryotic Secretory Components: the Candida albicans Homolog of the Saccharomyces cerevisiae Sec20 Protein Is N Terminally Truncated, and Its Levels Determine Antifungal Drug Resistance and Growth.
Y. Weber, U. J. Santore, J. F. Ernst, and R. K. Swoboda (2001)
J. Bacteriol. 183, 46-54
   Abstract »    Full Text »
High Density Lipoproteins and Arteriosclerosis : Role of Cholesterol Efflux and Reverse Cholesterol Transport.
A. von Eckardstein, J.-R. Nofer, and G. Assmann (2001)
Arterioscler Thromb Vasc Biol 21, 13-27
   Abstract »    Full Text »    PDF »
Small GTP-Binding Proteins.
Y. Takai, T. Sasaki, and T. Matozaki (2001)
Physiol Rev 81, 153-208
   Abstract »    Full Text »    PDF »
NEM and filipin increase albumin transport in lung microvessels.
B. Rippe and A. Taylor (2001)
Am J Physiol Heart Circ Physiol 280, H34-H41
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)