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Science 5 April 1996:
Vol. 272. no. 5258, pp. 50 - 54
DOI: 10.1126/science.272.5258.50
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Articles

The Instructive Role of Innate Immunity in the Acquired Immune Response

Douglas T. Fearon and Richard M. Locksley

Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops. However, innate immunity may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response. Knowledge of the molecules and pathways involved may create new therapeutic options for infectious and autoimmune diseases.

D. T. Fearon is at the Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge CB2 2SP, UK. R. M. Locksley is in the Department of Medicine, University of California, San Francisco, Post Office Box 0654, C-443, 521 Parnassus Avenue, San Francisco, CA 94143- 0654, USA.


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J. Biol. Chem. 278, 52386-52391
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Infect. Immun. 71, 7140-7148
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J. Virol. 77, 11644-11650
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Arch. Dis. Child. 88, 981-984
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Infect. Immun. 71, 4278-4288
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New approaches to investigating heterogeneity in complex traits.
R Bomprezzi, P E Kovanen, and R Martin (2003)
J. Med. Genet. 40, 553-559
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Conservation of Nonpeptide Antigen Recognition by Rhesus Monkey V{gamma}2V{delta}2 T Cells.
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J. Immunol. 170, 3696-3706
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Pertussis Toxin Enhances Th1 Responses by Stimulation of Dendritic Cells.
W. Hou, Y. Wu, S. Sun, M. Shi, Y. Sun, C. Yang, G. Pei, Y. Gu, C. Zhong, and B. Sun (2003)
J. Immunol. 170, 1728-1736
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Protection of Chickens against Escherichia coli Infections by DNA Containing CpG Motifs.
S. Gomis, L. Babiuk, D. L. Godson, B. Allan, T. Thrush, H. Townsend, P. Willson, E. Waters, R. Hecker, and A. Potter (2003)
Infect. Immun. 71, 857-863
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Endotoxin and Asthma.
W. Maziak, M. S. Perzanowski, T. A.E. Platts-Mills, D. E. Speiser, A. Zippelius, C. Braun-Fahrlander, R. P. Lauener, E. von Mutius, and S. T. Weiss (2003)
N. Engl. J. Med. 348, 171-174
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Functional and Morphological Development of Lymphoid Tissues and Immune Regulatory and Effector Function in Rhesus Monkeys: Cytokine-Secreting Cells, Immunoglobulin-Secreting Cells, and CD5+ B-1 Cells Appear Early in Fetal Development.
N. Makori, A. F. Tarantal, F. X. Lu, T. Rourke, M. L. Marthas, M. B. McChesney, A. G. Hendrickx, and C. J. Miller (2003)
Clin. Vaccine Immunol. 10, 140-153
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E. E. S. Nieuwenhuis, M. F. Neurath, N. Corazza, H. Iijima, J. Trgovcich, S. Wirtz, J. Glickman, D. Bailey, M. Yoshida, P. R. Galle, et al. (2002)
PNAS 99, 16951-16956
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CD40 ligation and phagocytosis differently affect the differentiation of monocytes into dendritic cells.
M. Rosenzwajg, F. Jourquin, L. Tailleux, and J. C. Gluckman (2002)
J. Leukoc. Biol. 72, 1180-1189
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Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction.
E. Latz, A. Visintin, E. Lien, K. A. Fitzgerald, B. G. Monks, E. A. Kurt-Jones, D. T. Golenbock, and T. Espevik (2002)
J. Biol. Chem. 277, 47834-47843
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Monocytes are progressively activated in the circulation of pregnant women.
P. Luppi, C. Haluszczak, D. Betters, C. A. H. Richard, M. Trucco, and J. A. DeLoia (2002)
J. Leukoc. Biol. 72, 874-884
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Subversion of the innate immune response by micro-organisms.
B Fernie-King, D J Seilly, A Davies, and P J Lachmann (2002)
Ann Rheum Dis 61, ii8-12
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Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis.
J E Salmon, G Girardi, and V M Holers (2002)
Ann Rheum Dis 61, ii46-50
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Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae.
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PNAS 99, 13705-13710
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   Abstract »    Full Text »    PDF »
Marginal Zone Macrophages and Immune Responses Against Viruses.
S. Oehen, B. Odermatt, U. Karrer, H. Hengartner, R. Zinkernagel, and C. Lopez-Macias (2002)
J. Immunol. 169, 1453-1458
   Abstract »    Full Text »    PDF »
Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro.
S. Nagakura, S. Ishihara, D. E. Dunn, J.-i. Nishimura, T. Kawaguchi, K. Horikawa, M. Hidaka, T. Kagimoto, N. Eto, H. Mitsuya, et al. (2002)
Blood 100, 1031-1037
   Abstract »    Full Text »    PDF »
Numerical and functional alterations of circulating {gamma}{delta} T lymphocytes in aged people and centenarians.
K. Argentati, F. Re, A. Donnini, M. G. Tucci, C. Franceschi, B. Bartozzi, G. Bernardini, and M. Provinciali (2002)
J. Leukoc. Biol. 72, 65-71
   Abstract »    Full Text »    PDF »
Natural recognition repertoire and the evolutionary emergence of the combinatorial immune system.
J. J. MARCHALONIS, S. KAVERI, S. LACROIX-DESMAZES, and M. D. KAZATCHKINE (2002)
FASEB J 16, 842-848
   Abstract »    Full Text »    PDF »
Regional manifestations and control of the immune system.
S. SAADI, L. E. WRENSHALL, and J. L. PLATT (2002)
FASEB J 16, 849-856
   Abstract »    Full Text »    PDF »
Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver.
H.-G. Zhang, J. Xie, L. Xu, P. Yang, X. Xu, S. Sun, Y. Wang, D. T. Curiel, H.-C. Hsu, and J. D. Mountz (2002)
J. Virol. 76, 5692-5700
   Abstract »    Full Text »    PDF »
Memorizing innate instructions requires a sufficiently specific adaptive immune system.
J. A. M. Borghans and R. J. De Boer (2002)
Int. Immunol. 14, 525-532
   Abstract »    Full Text »    PDF »
MIP-1alpha , MIP-1beta , RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines.
B. G. Dorner, A. Scheffold, M. S. Rolph, M. B. Huser, S. H. E. Kaufmann, A. Radbruch, I. E. A. Flesch, and R. A. Kroczek (2002)
PNAS 99, 6181-6186
   Abstract »    Full Text »    PDF »
Novel Signal Transduction Pathway Utilized by Extracellular HSP70. ROLE OF Toll-LIKE RECEPTOR (TLR) 2 AND TLR4.
A. Asea, M. Rehli, E. Kabingu, J. A. Boch, O. Bare, P. E. Auron, M. A. Stevenson, and S. K. Calderwood (2002)
J. Biol. Chem. 277, 15028-15034
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Three SIBLINGs (Small Integrin-Binding LIgand, N-linked Glycoproteins) Enhance Factor H's Cofactor Activity Enabling MCP-like Cellular Evasion of Complement-mediated Attack.
A. Jain, A. Karadag, B. Fohr, L. W. Fisher, and N. S. Fedarko (2002)
J. Biol. Chem. 277, 13700-13708
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Complement Receptor Type 1 (CD35) Mediates Inhibitory Signals in Human B Lymphocytes.
M. Jozsi, J. Prechl, Z. Bajtay, and A. Erdei (2002)
J. Immunol. 168, 2782-2788
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Adjuvants of Immunity: Harnessing Innate Immunity to Promote Adaptive Immunity.
A. Bendelac and R. Medzhitov (2002)
J. Exp. Med. 195, F19-F23
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Immunological changes in simian immunodeficiency virus (SIVagm)-infected African green monkeys (AGM): expanded cytotoxic T lymphocyte, natural killer and B cell subsets in the natural host of SIVagm.
E. Holznagel, S. Norley, S. Holzammer, C. Coulibaly, and R. Kurth (2002)
J. Gen. Virol. 83, 631-640
   Abstract »    Full Text »    PDF »
Toll Receptors: a Central Element in Innate Immune Responses.
T. Vasselon and P. A. Detmers (2002)
Infect. Immun. 70, 1033-1041
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