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Science 29 March 1996:
Vol. 271. no. 5257, pp. 1867 - 1870
DOI: 10.1126/science.271.5257.1867
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Reports

A Neural Tetraspanin, Encoded by late bloomer, That Facilitates Synapse Formation

Casey C. Kopczynski, Graeme W. Davis, Corey S. Goodman *

Upon contacting its postsynaptic target, a neuronal growth cone transforms into a presynaptic terminal. A membrane component on the growth cone that facilitates synapse formation was identified by means of a complementary DNA-based screen followed by genetic analysis. The late bloomer (lbl) gene in Drosophila encodes a member of the tetraspanin family of cell surface proteins. LBL protein is transiently expressed on motor axons, growth cones, and terminal arbors. In lbl mutant embryos, the growth cone of the RP3 motoneuron contacts its target muscles, but synapse formation is delayed and neighboring motoneurons display an increase in ectopic sprouting.

Howard Hughes Medical Institute, Neurobiology Division, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA.
* To whom correspondence should be addressed.


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