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Science 16 February 1996:
Vol. 271. no. 5251, pp. 978 - 981
DOI: 10.1126/science.271.5251.978
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Reports

Chain Migration of Neuronal Precursors

Carlos Lois,  Jose-Manuel García-Verdugo,  Arturo Alvarez-Buylla (1)

In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.


C. Lois and A. Alvarez-Buylla, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
J.-M. García-Verdugo, Facultad de Biológicas, Universitas Valencia, Burjassot, Valencia 46100, Spain.
(1) To whom correspondence should be addressed.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Y. Ruan, L. Tecott, M.-M. Jiang, L. Y. Jan, and Y. N. Jan (2001)
PNAS
   Abstract »    Full Text »    PDF »
Early-generated Preplate Neurons in the Developing Telencephalon: Inward Migration into the Developing Striatum.
T. Hamasaki, S. Goto, S. Nishikawa, and Y. Ushio (2001)
Cereb Cortex 11, 474-484
   Abstract »    Full Text »    PDF »
Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.
K. Jin, M. Minami, J. Q. Lan, X. O. Mao, S. Batteur, R. P. Simon, and D. A. Greenberg (2001)
PNAS 98, 4710-4715
   Abstract »    Full Text »    PDF »
The generation, migration, and differentiation of olfactory neurons in the adult primate brain.
D. R. Kornack and P. Rakic (2001)
PNAS 98, 4752-4757
   Abstract »    Full Text »    PDF »
The N-terminal Leucine-Rich Regions in Slit Are Sufficient To Repel Olfactory Bulb Axons and Subventricular Zone Neurons.
J.-h. Chen, L. Wen, S. Dupuis, J. Y. Wu, and Y. Rao (2001)
J. Neurosci. 21, 1548-1556
   Abstract »    Full Text »    PDF »
FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.
S. M. Jenkins, K. Kizhatil, N. R. Kramarcy, A. Sen, R. Sealock, and V. Bennett (2001)
J. Cell Sci. 114, 3823-3835
   Abstract »    Full Text »    PDF »
Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons.
R. S. Bhatt, T. Tomoda, Y. Fang, and M. E. Hatten (2000)
Genes & Dev. 14, 2216-2228
   Abstract »    Full Text »


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